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Anti-DCD Monoclonal Antibody

产品编号 TMAZ-0265
别名 Dermcidin, Preproteolysin

Anti-DCD Monoclonal Antibody is a rabbit antibody targeting DCD. Anti-DCD Monoclonal Antibody can be used in ELISA, FACS.

Anti-DCD Monoclonal Antibody

Anti-DCD Monoclonal Antibody

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产品编号 TMAZ-0265 别名 Dermcidin, Preproteolysin

Anti-DCD Monoclonal Antibody is a rabbit antibody targeting DCD. Anti-DCD Monoclonal Antibody can be used in ELISA, FACS.

规格价格库存数量
25 μg¥ 725¥ 1,2507日内发货
50 μg¥ 870¥ 1,5007日内发货
100 μg¥ 1,217.42¥ 2,0997日内发货
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产品介绍

生物活性
产品描述
Anti-DCD Monoclonal Antibody is a rabbit antibody targeting DCD. Anti-DCD Monoclonal Antibody can be used in ELISA, FACS.
别名Dermcidin, Preproteolysin
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of DCD overexpressed 472F cells with TMAZ-0265, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of DCD protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Found in sweat, has an antimicrobial activity during early bacterial colonization (PubMed: 11694882, PubMed: 23426625). The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes (PubMed: 23426625). Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival (PubMed: 23426625). Highly effective against E.coli, E.faecalis, S.aureus and C.albicans (PubMed: 11694882). Optimal pH and salt concentration resemble the conditions in sweat (PubMed: 11694882). Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed: 17448443)|Promotes survival of neurons and displays phosphatase activity (PubMed: 9736629). It may bind IgG (PubMed: 9736629)
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin/APC/PE/AF488/AF555/AF647
可提供抗体种类
1
抗原信息
免疫原
DCD
抗原种属
Human
基因ID
117159
Uniprot ID
研究领域
Other Functions
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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