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MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | |
50 mg | ¥ 13,800 | 6-8周 | |
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity. |
体外活性 | MTH1 is an inhibitors ?and for use in the treatment or prevention of cancer.The enzyme human MTH1 is a 2-hydroxy-dATP diphosphatase.?MTH1 specifically assists RAS-induced tumors in preventing tumor- suppressive effects such as senescence whilst enabling maintenance and progression of the tumor.?MTH1 inhibition helps impairing tumor growth by abrogating mitogenic signaling, epithelial-mesenchymal transition (EMT), a hallmark of progressing and aggressive tumors, anoikis inhibition and PI3K/Akt-mediated pro-survival signaling.?MTH1 inhibitors induce oxidative DNA lesions[1]. |
分子量 | 469.55 |
分子式 | C24H27N3O5S |
CAS No. | 901044-91-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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