(R)-JNJ-31020028

Name: (R)-JNJ-31020028
Brand: TargetMol
SKU: T12623
Rating: 4.5 (1 reviews)

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产品编号 T12623Cas号 1094873-17-2

(R)-JNJ-31020028 is a high-affinity, selective brain-penetrant antagonist of the neuropeptide Y Y2 receptor, with pIC50 values of 8.07, 8.22, and 8.21 for human, rat, and mouse Y2 receptors, respectively.

(R)-JNJ-31020028

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产品编号 T12623Cas号 1094873-17-2

规格	价格	库存	数量
100 mg	询价	期货
500 mg	询价	期货

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产品描述	(R)-JNJ-31020028 is a high-affinity, selective brain-penetrant antagonist of the neuropeptide Y Y2 receptor, with pIC50 values of 8.07, 8.22, and 8.21 for human, rat, and mouse Y2 receptors, respectively.
靶点活性	Y2 receptor (mouse):8.21(pIC50), Y2 receptor (human):8.07(pIC50), Y2 receptor (rat):8.22(pIC50)
体内活性	Chronic icv administration of (R)-JNJ-31020028 at 5.6 μg/day using osmotic Alzet pump resulted in a significant decreases number of grooming events[1]. (R)-JNJ-31020028 treatment shows the Cmax, Tmax , AUCinf, Vd, and t1/2 were 4.35 μM, 0.5 hours, 7.91 h μM and 0.83 hours, respectively. (R)-JNJ-31020028 has antidepressant like effects in the olfactory bulbectomized rat (OBX) model. [1].