ST4206

Name: ST4206
Brand: TargetMol
SKU: T14015
Price: 294 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T14015Cas号 1246018-36-9

ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively.

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产品编号 T14015Cas号 1246018-36-9

ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively.

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生物活性

产品描述	ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively.
靶点活性	A2A receptor:（ki）12 nM, A1 receptor:197 nM（ki）
体外活性	ST4206 inhibits agonist-induced cAMP accumulation (IC50: 990 nM)[1].
体内活性	ST4206 (10, 20, and 40 mg/kg, p.o.) antagonizes haloperidol-induced catalepsy, and increases motor activity in a dose dependent manner in mice. ST4206 (20 and 40 mg/kg) significantly increases the number of contralateral turns induced by l-DOPA in rats[1]. ST4206 is orally active at concentrations of 10, 20, and 40 mg/kg in haloperidol-induced catalepsy in mice[2].