Ro15-4513

Name: Ro15-4513
Brand: TargetMol
SKU: T16775
Rating: 4.5 (1 reviews)

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产品编号 T16775Cas号 91917-65-6

Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.

Ro15-4513

还可以

产品编号 T16775Cas号 91917-65-6

Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.

规格	价格	库存
2 mg	¥ 1,460	5日内发货
25 mg	¥ 9,390	6-8周
50 mg	¥ 12,200	6-8周
100 mg	¥ 17,500	6-8周

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生物活性

产品描述	Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.
体外活性	Ro15-4513 usually acts as a partial inverse agonist at GABAA receptors [3].
体内活性	Ro 15-4513 (i.p.; 3?mg/kg; 15?min before administration of 1.5?g/kg ethanol) reverses ethanol-induced sedation in GABAA receptor δ subunit-deficient mice. Ro 15-4513 (i.p.; 3?mg/kg; 10?min before being tested) fully inhibits the ethanol-induced (1.8?g/kg) reduction in total locomotor activity and partly the reduction in rearing [2].