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PROTAC SMARCA2/4-degrader-20 (Compound I-405) 作为一种高效的PROTAC降解剂,针对SWI/SNF复合体中的催化亚基SMARCA2进行特异性降解.该化合物在MV411和A549细胞系中对SMARCA2具有极佳的降解效果,其DC50值均小于100 nM;同时,在MV411细胞中对SMARCA4的降解效率也表现出色,DC50值在100-500 nM范围内.
PROTAC SMARCA2/4-degrader-20 (Compound I-405) 作为一种高效的PROTAC降解剂,针对SWI/SNF复合体中的催化亚基SMARCA2进行特异性降解.该化合物在MV411和A549细胞系中对SMARCA2具有极佳的降解效果,其DC50值均小于100 nM;同时,在MV411细胞中对SMARCA4的降解效率也表现出色,DC50值在100-500 nM范围内.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader targeting the catalytic subunit SMARCA2 in the SWI/SNF complex. It degrades SMARCA2 in MV411 and A549 cell lines with a DC50 of less than 100 nM. Additionally, it degrades SMARCA4 in MV411 with a DC50 ranging between 100 to 500 nM. |
分子量 | 998.13 |
分子式 | C50H58F3N11O6S |
CAS No. | 2568277-38-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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