JAK-2/3-IN-1

Name: JAK-2/3-IN-1
Brand: TargetMol
SKU: T38436
Price: 795 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T38436Cas号 1036241-36-7

JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.

JAK-2/3-IN-1

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产品编号 T38436Cas号 1036241-36-7

JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.

规格	价格	库存	数量
25 mg	¥ 10,600	6-8周

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生物活性

产品描述	JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.
靶点活性	JAK2:<250 nM (Ki), JAK3:<250 nM (Ki)
体外活性	The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies[1].