Dexanabinol (HU-211) is a synthetic cannabinoid derivative devoid of cannabimimetic effects. It demonstrates antioxidant, neuroprotective, and anti-inflammatory activities by inhibiting NF-κB and reducing cytokines like TNFα and interleukin-6, thereby maintaining BBB integrity and decreasing cell apoptosis and death. Dexanabinol is extensively employed in treating head injuries and strokes and has proven safe in both animals and humans.