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Anti-SPN Monoclonal Antibody-Biotin
产品编号 TMAZ-0371B
别名 Leukosialin, GPL115, Leukocyte sialoglycoprotein, Galactoglycoprotein, Sialophorin
Anti-SPN Monoclonal Antibody-Biotin is a biotin-conjugated rabbit antibody targeting SPN. Anti-SPN Monoclonal Antibody-Biotin can be used in ELISA, FACS.
Anti-SPN Monoclonal Antibody-Biotin
Anti-SPN Monoclonal Antibody-Biotin
产品编号 TMAZ-0371B 别名 Leukosialin, GPL115, Leukocyte sialoglycoprotein, Galactoglycoprotein, Sialophorin
Anti-SPN Monoclonal Antibody-Biotin is a biotin-conjugated rabbit antibody targeting SPN. Anti-SPN Monoclonal Antibody-Biotin can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 2,087.42¥ 3,599 | 7日内发货 | |
| 50 μg | ¥ 3,478.84¥ 5,998 | 7日内发货 | |
| 100 μg | ¥ 5,218.26¥ 8,997 | 7日内发货 |
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| 产品描述 | Anti-SPN Monoclonal Antibody-Biotin is a biotin-conjugated rabbit antibody targeting SPN. Anti-SPN Monoclonal Antibody-Biotin can be used in ELISA, FACS. |
| 别名 | Leukosialin, GPL115, Leukocyte sialoglycoprotein, Galactoglycoprotein, Sialophorin |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of SPN overexpressed 441F cells with TMAZ-0371B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of SPN protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity)|Protects cells from apoptotic signals, promoting cell survival |
| 其他可选修饰符 | APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 2 |
| 免疫原 | SPN |
| 抗原种属 | Human |
| 基因ID | 6693 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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