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Anti-PD-L1 Monoclonal Antibody-APC
产品编号 TMAZ-0055A
别名 Programmed cell death 1 ligand 1, B7 homolog 1
Anti-PD-L1 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-APC can be used in ELISA, FACS, IF.
Anti-PD-L1 Monoclonal Antibody-APC
Anti-PD-L1 Monoclonal Antibody-APC
产品编号 TMAZ-0055A 别名 Programmed cell death 1 ligand 1, B7 homolog 1
Anti-PD-L1 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-APC can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,335.74¥ 2,303 | 7日内发货 | |
| 50 μg | ¥ 2,226.04¥ 3,838 | 7日内发货 | |
| 100 μg | ¥ 3,339.06¥ 5,757 | 7日内发货 |
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| 产品描述 | Anti-PD-L1 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-APC can be used in ELISA, FACS, IF. |
| 别名 | Programmed cell death 1 ligand 1, B7 homolog 1 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of PD-L1 overexpressed 293F cells with TMAZ-0055ABI, which was counjucated with SA-PE (red). The WT 293F control is black line. |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PD-L1 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed: 11015443, PubMed: 28813410, PubMed: 28813417, PubMed: 31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed: 11015443, PubMed: 28813410, PubMed: 28813417, PubMed: 36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed: 10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed: 32929201)|The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed: 28813410, PubMed: 28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity) |
| 偶联 | APC |
| 其他可选修饰符 | Biotin/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | PD-L1 |
| 抗原种属 | Human |
| 基因ID | 29126 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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