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Anti-PD-1 Monoclonal Antibody-AF555
产品编号 TMAZ-0006A5
别名 Programmed cell death protein 1
Anti-PD-1 Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting PD-1. Anti-PD-1 Monoclonal Antibody-AF555 can be used in ELISA, FACS.
Anti-PD-1 Monoclonal Antibody-AF555
Anti-PD-1 Monoclonal Antibody-AF555
产品编号 TMAZ-0006A5 别名 Programmed cell death protein 1
Anti-PD-1 Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting PD-1. Anti-PD-1 Monoclonal Antibody-AF555 can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 2,087.42¥ 3,599 | 7日内发货 | |
| 50 μg | ¥ 3,478.84¥ 5,998 | 7日内发货 | |
| 100 μg | ¥ 5,218.26¥ 8,997 | 7日内发货 |
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| 产品描述 | Anti-PD-1 Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting PD-1. Anti-PD-1 Monoclonal Antibody-AF555 can be used in ELISA, FACS. |
| 别名 | Programmed cell death protein 1 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of PD-1 overexpressed 417F cells with TMAZ-0006A5, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PD-1 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed: 21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed: 21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity)|The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed: 28951311). The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed: 28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed: 22658127, PubMed: 25034862, PubMed: 25399552) |
| 偶联 | AF555 |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF647 |
| 可提供抗体种类 | 3 |
| 免疫原 | PD-1 |
| 抗原种属 | Human |
| 基因ID | 5133 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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