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Anti-LAIR1 Monoclonal Antibody-PE
产品编号 TMAZ-0197P
别名 Leukocyte-associated immunoglobulin-like receptor 1
Anti-LAIR1 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting LAIR1. Anti-LAIR1 Monoclonal Antibody-PE can be used in ELISA, FACS.
Anti-LAIR1 Monoclonal Antibody-PE
Anti-LAIR1 Monoclonal Antibody-PE
产品编号 TMAZ-0197P 别名 Leukocyte-associated immunoglobulin-like receptor 1
Anti-LAIR1 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting LAIR1. Anti-LAIR1 Monoclonal Antibody-PE can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 2,087.42¥ 3,599 | 7日内发货 | |
| 50 μg | ¥ 3,478.84¥ 5,998 | 7日内发货 | |
| 100 μg | ¥ 5,218.26¥ 8,997 | 7日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-LAIR1 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting LAIR1. Anti-LAIR1 Monoclonal Antibody-PE can be used in ELISA, FACS. |
| 别名 | Leukocyte-associated immunoglobulin-like receptor 1 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of LAIR1 overexpressed 293F cells with TMAZ-0197PBI, which was counjucated with SA-PE (red). The WT 293F control is black line. |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of LAIR1 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in PBS. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells |
| 偶联 | PE |
| 其他可选修饰符 | Biotin/APC/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | LAIR1 |
| 抗原种属 | Human |
| 基因ID | 3903 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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