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Anti-IL10 Monoclonal Antibody-APC
产品编号 TMAZ-0029A
别名 Interleukin-10, Cytokine synthesis inhibitory factor
Anti-IL10 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody-APC can be used in ELISA, FACS, IF.
Anti-IL10 Monoclonal Antibody-APC
Anti-IL10 Monoclonal Antibody-APC
产品编号 TMAZ-0029A 别名 Interleukin-10, Cytokine synthesis inhibitory factor
Anti-IL10 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody-APC can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 2,087.42¥ 3,599 | 7日内发货 | |
| 50 μg | ¥ 3,478.84¥ 5,998 | 7日内发货 | |
| 100 μg | ¥ 5,218.26¥ 8,997 | 7日内发货 |
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偶联与修饰
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| 产品描述 | Anti-IL10 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody-APC can be used in ELISA, FACS, IF. |
| 别名 | Interleukin-10, Cytokine synthesis inhibitory factor |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of IL10 overexpressed 353F cells with TMAZ-0029A, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL10 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed: 16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed: 18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed: 11564774, PubMed: 1940799, PubMed: 7512027). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed: 8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity) |
| 偶联 | APC |
| 其他可选修饰符 | Biotin/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | IL10 |
| 抗原种属 | Human |
| 基因ID | 3586 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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