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Anti-AGT Monoclonal Antibody
还可以产品编号 TMAZ-0159
别名 Serpin A8, Angiotensinogen
Anti-AGT Monoclonal Antibody is a rabbit antibody targeting AGT. Anti-AGT Monoclonal Antibody can be used in ELISA, FACS.
Anti-AGT Monoclonal Antibody
Anti-AGT Monoclonal Antibody
还可以产品编号 TMAZ-0159 别名 Serpin A8, Angiotensinogen
Anti-AGT Monoclonal Antibody is a rabbit antibody targeting AGT. Anti-AGT Monoclonal Antibody can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,250 | 7日内发货 | |
| 50 μg | ¥ 1,500 | 7日内发货 | |
| 100 μg | ¥ 2,099 | 7日内发货 |
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生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-AGT Monoclonal Antibody is a rabbit antibody targeting AGT. Anti-AGT Monoclonal Antibody can be used in ELISA, FACS. |
| 别名 | Serpin A8, Angiotensinogen |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of AGT overexpressed 435F cells with TMAZ-0159, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of AGT protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis|Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (PubMed: 10619573, PubMed: 17138938). Acts by binding to angiotensin receptors AGTR1 and AGTR2 (PubMed: 1567413). Also binds the DEAR/FBXW7-AS1 receptor (By similarity)|Stimulates aldosterone release|Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity) |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 5 |
| 免疫原 | AGT |
| 抗原种属 | Human |
| 基因ID | 183 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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