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Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. It is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1].
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Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. It is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1].
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 211 | 5日内发货 | |
5 mg | ¥ 433 | 5日内发货 | |
10 mg | ¥ 615 | 5日内发货 | |
25 mg | ¥ 970 | 5日内发货 | |
50 mg | ¥ 1,650 | 5日内发货 | |
100 mg | ¥ 2,950 | 5日内发货 |
产品描述 | Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. It is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1]. |
体外活性 | Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is composed of Degron (E3 ubiquitin ligase) and a linker, and they are used in PROTAC technology. Thalidomide-O-amido-PEG3-C2-NH2 binds to the targeting ligand to induce the target protein (including BRD4, BRD2, and BRD3) degradation[1]. |
分子量 | 542.97 |
分子式 | C23H31ClN4O9 |
CAS No. | 2245697-84-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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