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TDN345
还可以产品编号 T13107Cas号 134069-68-4
TDN345 is a antagonist of Ca2+, for the treatment of vascular and senile dementia including Alzheimer's disease.
TDN345
还可以产品编号 T13107Cas号 134069-68-4
TDN345 is a antagonist of Ca2+, for the treatment of vascular and senile dementia including Alzheimer's disease.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 11,700 | 6-8周 | |
| 50 mg | ¥ 15,300 | 6-8周 | |
| 100 mg | ¥ 19,500 | 6-8周 |
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产品介绍
生物活性
化学信息
| 产品描述 | TDN345 is a antagonist of Ca2+, for the treatment of vascular and senile dementia including Alzheimer's disease. |
| 体外活性 | In the time-course study,TDN-345 treatment with 10 μM significantly increases the intracellular NGF content. TDN-345 induces NGF synthesis/secretion at the concentrations of 0.1 μM; statistically significant at 1 μM(ED50 of 0.88 μM)[1]. |
| 体内活性 | When administered orally twice TDN-345 (0.1-1.0 mg/kg, p.o.) dose-dependently decreases the mortality and ischemic neurological deficit score, 60 min before ischemia and 90 min after recirculation. Additionally, In SHRSP, TDN-345 decreases the mortality and recurrence of stroke [2]. |
| 分子量 | 468.58 |
| 分子式 | C28H34F2N2O2 |
| CAS No. | 134069-68-4 |
| 密度 | 1.18 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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