Rociletinib hydrobromide

Name: Rociletinib hydrobromide
Brand: TargetMol
SKU: T14993
Price: -1 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T14993Cas号 1446700-26-0

别名 CO-1686 (hydrobromide), CNX-419 hydrobromide, AVL-301 hydrobromide

Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).

Rociletinib hydrobromide

还可以

产品编号 T14993 别名 CO-1686 (hydrobromide), CNX-419 hydrobromide, AVL-301 hydrobromideCas号 1446700-26-0

Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).

规格	价格	库存
2 mg	¥ 252	5日内发货
5 mg	¥ 413	5日内发货
10 mg	¥ 663	5日内发货
25 mg	¥ 1,130	5日内发货
1 mL x 10 mM (in DMSO)	¥ 578	5日内发货

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产品介绍

生物活性

产品描述	Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).
靶点活性	EGFR (T790M):303.3 nM （ki）, EGFR (L858R/T790M):21.5 nM （ki）
体外活性	Rociletinib resistant NSCLC cell lines are sensitive to AKT inhibition. Rociletinib selectively inhibits the growth of NSCLC cells expressing mutant EGFR and induces apoptosis. Rociletinib (0.1 μM) inhibits EGFR potently and irreversibly. It inhibits more than 50% of 23 targets.
体内活性	Rociletinib (50 mg/kg bid, p.o.) shows anti-tumor activity in human EGFR-L858R and EGFR-L858R-T790M expressing transgenic mice. Rociletinib (100 mg/kg/day, p.o.) displays anti-tumor activity in NSCLC EGFR mutant xenograft models.
别名	CO-1686 (hydrobromide), CNX-419 hydrobromide, AVL-301 hydrobromide

化学信息

分子量	636.46
分子式	C₂₇H₂₉BrF₃N₇O₃
CAS No.	1446700-26-0
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 59 mg/mL (92.70 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5712 mL	7.8560 mL	15.7119 mL	78.5595 mL
5 mM	0.3142 mL	1.5712 mL	3.1424 mL	15.7119 mL
10 mM	0.1571 mL	0.7856 mL	1.5712 mL	7.8560 mL
20 mM	0.0786 mL	0.3928 mL	0.7856 mL	3.9280 mL
50 mM	0.0314 mL	0.1571 mL	0.3142 mL	1.5712 mL