CMLD012612

Name: CMLD012612
Brand: TargetMol
SKU: T10849
Price: 233 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T10849Cas号 2368900-35-8

CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).

CMLD012612

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产品编号 T10849Cas号 2368900-35-8

CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).
体外活性	The primary mechanism of action of CMLD012612 is dependent on eIF4A1 since eIF4A1em1jp cells are at least 10-fold more resistant than parental NIH/3T3 cells. The sensitivity of eIF4A1em1jp cells to CMLD012612 observed at higher concentrations may be due to the presence of wild-type eIF4A2 in the cells.
体内活性	When administered to mice bearing myr-Akt/Em-Myc lymphomas, CMLD012612 (0.2 mg/kg; i.p.; daily; for 5 days; female C57BL/6 mice) treatment effectively synergizes with Doxorubicin, leading to complete tumor loss. CMLD012612 (0.5 mg/kg; i.p.; for 3 hours; female C57BL/6 mice) treatment effectively suppresses liver polysomes 3 hours after injection.