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BAY-7598
产品编号 T10474Cas号 1816257-74-5
BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
BAY-7598
产品编号 T10474Cas号 1816257-74-5
BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 19,400 | 10-14周 | |
| 50 mg | ¥ 25,800 | 10-14周 | |
| 100 mg | ¥ 33,500 | 10-14周 |
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产品介绍
生物活性
化学信息
| 产品描述 | BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12). |
| 靶点活性 | MMP12 (rat):1.1 nM , MMP12 (human):0.085 nM , MMP12 (murine):0.67 nM |
| 体外活性 | BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 (IC50s: 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM). BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 (IC50s: 45, 270, 130, 54, and 210 nM). BAY-7598 inhibits rat MMP2, MMP8, and MMP9 (IC50s: 45, 67, and 1000 nM). |
| 体内活性 | BAY-7598 has moderate terminal elimination half-life (t1/2=4.1 h and 4.6 h for mouse (5.0 mg/kg, p.o.), mouse (0.3 mg/kg, iv), respectively). |
| 分子量 | 505.56 |
| 分子式 | C28H31N3O6 |
| CAS No. | 1816257-74-5 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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