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6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.
6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,120 | 35日内发货 | |
5 mg | ¥ 4,900 | 35日内发货 | |
10 mg | ¥ 8,690 | 35日内发货 |
产品描述 | 6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2. |
别名 | 6β-Prostaglandin I1 |
分子量 | 354.487 |
分子式 | C20H34O5 |
CAS No. | 62770-50-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMF: >10 (from 6b-PGI1) DMSO: >5 (from 6b-PGI1) PBS (pH 7.2): >80 μg (from 6b-PGI1) Ethanol: >20 mg/mL (from 6b-PGI1) |
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