keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 185 | 现货 | ||
2 mg | ¥ 257 | 现货 | ||
5 mg | ¥ 412 | 现货 | ||
10 mg | ¥ 598 | 现货 | ||
25 mg | ¥ 993 | 现货 | ||
50 mg | ¥ 1,490 | 现货 | ||
100 mg | ¥ 2,230 | 现货 |
产品描述 | (S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology. |
体外活性 | E3 ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins[1]. |
别名 | VH032-PEG4-N3, VHL Ligand-Linker Conjugates 5, E3 ligase Ligand-Linker Conjugates 4 |
分子量 | 689.83 |
分子式 | C32H47N7O8S |
CAS No. | 1797406-81-5 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (65.2 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.4496 mL | 7.2482 mL | 14.4963 mL | 36.2408 mL |
5 mM | 0.2899 mL | 1.4496 mL | 2.8993 mL | 7.2482 mL | |
10 mM | 0.145 mL | 0.7248 mL | 1.4496 mL | 3.6241 mL | |
20 mM | 0.0725 mL | 0.3624 mL | 0.7248 mL | 1.812 mL | |
50 mM | 0.029 mL | 0.145 mL | 0.2899 mL | 0.7248 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(S,R,S)-AHPC-PEG4-N3 1797406-81-5 Others PROTAC PROTAC Linker VH032-PEG4-N3 VHL Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 4 AHPC-PEG4-N3 Inhibitor inhibitor inhibit