Inotersen sodium

Name: Inotersen sodium
Brand: TargetMol
SKU: T38909
Rating: 4.5 (1 reviews)

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产品编号 T38909Cas号 1432726-13-0

别名 ISIS-420915 sodium

Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, thereby reducing TTR transcript levels. Inotersen sodium holds potential for research on hereditary TTR amyloidosis polyneuropathy.

Inotersen sodium

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产品编号 T38909 别名 ISIS-420915 sodiumCas号 1432726-13-0

规格	价格	库存	数量
5 mg	¥ 15,600	期货
10 mg	¥ 23,300	期货

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产品描述	Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, thereby reducing TTR transcript levels. Inotersen sodium holds potential for research on hereditary TTR amyloidosis polyneuropathy.
体外活性	Inotersen sodium (0.16-20 μM; 16 h) dose-dependently reduces TTR mRNA levels in HepG2 cells[1].
体内活性	Inotersen sodium (10-100 mg/kg; s.c. twice a week for 4 weeks) reduces the plasma TTR protein by >80% in transgenic mice bearing the Ile84Ser human TTR mutant[1].
别名	ISIS-420915 sodium