Givosiran

Name: Givosiran
Brand: TargetMol
SKU: T39123
Price: 476 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T39123Cas号 1639325-43-1

别名 Givosiran, ALN-AS1

Givosiran (ALN-AS1) is a small interfering RNA (siRNA) compound that specifically targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA (mRNA) to downregulate its expression. By doing so, Givosiran effectively inhibits the accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. This compound holds significant potential for further research on acute intermittent porphyria.

Givosiran

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产品编号 T39123 别名 Givosiran, ALN-AS1Cas号 1639325-43-1

规格	价格	库存	数量
1 mg	询价	期货
5 mg	询价	期货

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产品介绍

生物活性

产品描述	Givosiran (ALN-AS1) is a small interfering RNA (siRNA) compound that specifically targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA (mRNA) to downregulate its expression. By doing so, Givosiran effectively inhibits the accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. This compound holds significant potential for further research on acute intermittent porphyria.
体外活性	Givosiran is conjugated to a trivalent N-acetylgalactosamine ligand, which binds specifically to the asialoglycoprotein receptor, enabling targeted delivery to hepatocytes[2].
别名	Givosiran, ALN-AS1