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Anti-CLU Monoclonal Antibody is a rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody can be used in ELISA, FACS, IF.
Anti-CLU Monoclonal Antibody is a rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody can be used in ELISA, FACS, IF.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 μg | ¥ 901.9¥ 1,555 | 7日内发货 | |
50 μg | ¥ 1,081.7¥ 1,865 | 7日内发货 | |
100 μg | ¥ 1,514.38¥ 2,611 | 7日内发货 |
产品描述 | Anti-CLU Monoclonal Antibody is a rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody can be used in ELISA, FACS, IF. |
别名 | Ku70-binding protein 1, Apolipoprotein J, NA1/NA2, Sulfated glycoprotein 2, Clusterin, Complement-associated protein SP-40,40, Aging-associated gene 4 protein, Testosterone-repressed prostate message 2, Complement cytolysis inhibitor |
Ig Type | Rabbit monoclonal IgG |
交叉反应 | Human |
验证活性 | Flow cytometry analysis of CLU overexpressed 355F cells with TMAZ-0178, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
应用 | ELISA, FACS, IF |
推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
亚细胞定位 | Single-pass type I membrane |
构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CLU protein. |
纯化方式 | Protein A Affinity Purified |
性状 | Liquid |
缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
纯度 | > 95% as determined by SDS-PAGE. |
研究背景 | Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed: 11123922, PubMed: 19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed: 11123922, PubMed: 12176985, PubMed: 17260971, PubMed: 19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed: 12047389, PubMed: 17407782, PubMed: 17412999). Does not require ATP (PubMed: 11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed: 11123922). Does not refold proteins by itself (PubMed: 11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed: 21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed: 2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed: 20068069). Modulates NF-kappa-B transcriptional activity (PubMed: 12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed: 16113678, PubMed: 17689225). Plays a role in the regulation of cell proliferation (PubMed: 19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed: 22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity)|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed: 21567405) |
偶联 | Unconjugated |
其他可选修饰符 | Biotin/APC/PE/AF488/AF555/AF647 |
可提供抗体种类 | 3 |
免疫原 | CLU |
抗原种属 | Human |
基因ID | 1191 |
Uniprot ID | |
研究领域 | Drug Target |
分子量 | 150 kDa |
储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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