Tos-PEG2-NH-Boc

Name: Tos-PEG2-NH-Boc
Brand: TargetMol
SKU: T18850
Price: 4790 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T18850Cas号 192132-77-7

Tos-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tos-PEG2-NH-Boc

还可以

产品编号 T18850Cas号 192132-77-7

规格	价格	库存	数量
1 g	¥ 621	5日内发货

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产品介绍

生物活性

产品描述	Tos-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
体外活性	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

化学信息

分子量	359.44
分子式	C₁₆H₂₅NO₆S
CAS No.	192132-77-7
密度	1.179 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 250 mg/mL (695.53 mM), Sonication is recommended.

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.7821 mL	13.9105 mL	27.8211 mL	139.1053 mL
5 mM	0.5564 mL	2.7821 mL	5.5642 mL	27.8211 mL
10 mM	0.2782 mL	1.3911 mL	2.7821 mL	13.9105 mL
20 mM	0.1391 mL	0.6955 mL	1.3911 mL	6.9553 mL
50 mM	0.0556 mL	0.2782 mL	0.5564 mL	2.7821 mL
100 mM	0.0278 mL	0.1391 mL	0.2782 mL	1.3911 mL