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Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).
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Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 352 | 现货 | |
5 mg | ¥ 788 | 现货 | |
10 mg | ¥ 1,330 | 现货 | |
25 mg | ¥ 2,660 | 现货 | |
50 mg | ¥ 3,930 | 现货 | |
100 mg | ¥ 5,730 | 现货 | |
500 mg | ¥ 11,800 | 现货 |
产品描述 | Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ). |
体外活性 | In in vitro binding studies, compared with Chrysamine-G (Ki = 25.3 nM), Methoxy-X04 exhibited similar binding affinity for Aβ fibrils (Ki = 26.8 nM) [1]. On brain slices of 12-month-old APP-PS1 (dE9) mice, 145 μM Methoxy-X04 was used for labeling fibrillary amyloid deposits [3]. |
体内活性 | In PS1/APP mice, a single i.v. injection of 5 to 10 mg/kg Methoxy-X04 distinguished individual plaques from brain fluorescent images, within 30 to 60 min after treatment. A single i.p. injection of 10 mg/kg Methoxy-X04 also produced high contrast images of plaques and cerebrovascular amyloid in PS1/APP mouse brains [1]. |
分子量 | 344.4 |
分子式 | C23H20O3 |
CAS No. | 863918-78-9 |
Smiles | COc1cc(\C=C\c2ccc(O)cc2)ccc1\C=C\c1ccc(O)cc1 |
密度 | 1.244 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 3.44 mg/mL (10 mM) | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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