LysRs-IN-2

Name: LysRs-IN-2
Brand: TargetMol
SKU: T11920
Price: 10600 USD
Availability: InStock
Rating: 5 (10 reviews)

很棒

产品编号 T11920Cas号 2170696-76-9

LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.13 μM and 0.015 μM for Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS) and Plasmodium falciparum lysyl-tRNA synthetase (PfKRS), respectively.

LysRs-IN-2

很棒

产品编号 T11920Cas号 2170696-76-9

规格	价格	库存
25 mg	¥ 10,600	现货
50 mg	¥ 13,800	现货
100 mg	¥ 17,500	现货

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产品介绍

生物活性

产品描述	LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.13 μM and 0.015 μM for Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS) and Plasmodium falciparum lysyl-tRNA synthetase (PfKRS), respectively.
靶点活性	PfKRS:0.015 μM , CpKRS:0.13 μM
体外活性	LysRs-IN-2 is active against whole-cell bloodstream P. falciparum 3D7 (EC50=0.27 μM),HepG2 cells (EC50=49 μM) , HsKRS (IC50=1.8 μM), and Cryptosporidium parvum (EC50=2.5 μM)[1].
体内活性	LysRs-IN-2 (20 mg/kg; orally once a day for 7 days) reduces parasite shedding in NOD SCID gamma mice and INF-γ-knockout mice (Cryptosporidium mouse models)[1].LysRs-IN-2 (1.5 mg/kg; orally once a day for 4 days) reduces parasitemia by 90% in the murine P. falciparum SCID model.

化学信息

分子量	355.31
分子式	C₁₇H₁₆F₃NO₄
CAS No.	2170696-76-9
密度	1.44 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 60 mg/mL (168.87 mM)

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.8144 mL	14.0722 mL	28.1444 mL	140.7222 mL
5 mM	0.5629 mL	2.8144 mL	5.6289 mL	28.1444 mL
10 mM	0.2814 mL	1.4072 mL	2.8144 mL	14.0722 mL
20 mM	0.1407 mL	0.7036 mL	1.4072 mL	7.0361 mL
50 mM	0.0563 mL	0.2814 mL	0.5629 mL	2.8144 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4072 mL