BPH-1358 free base

Name: BPH-1358 free base
Brand: TargetMol
SKU: T10586
Price: 1300 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T10586Cas号 801985-13-7

别名 NSC50460 free base

BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).

BPH-1358 free base

还可以

产品编号 T10586 别名 NSC50460 free baseCas号 801985-13-7

规格	价格	库存
25 mg	¥ 10,600	1-2周
50 mg	¥ 13,800	1-2周
100 mg	¥ 17,500	1-2周

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产品介绍

生物活性

产品描述	BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).
靶点活性	Bisphosphonate farnesyl diphosphate synthase (human):1.8 μM
体外活性	BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) and S. aureus UPPS (SaUPPS) (IC50: 110 nM). BPH-1358 against E. coli and S. aureus (EC50s: 300 nM and 290 nM) [1].
体内活性	In an i.p. infection model with an MRSA strain, BPH-1358 is active against S. aureus (20/20 mice survived) [1].
别名	NSC50460 free base