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TargetMol | Compound Library

细胞凋亡化合物库现货

Apoptosis Compound Library

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产品编号 L9000

细胞凋亡是一种发生在多细胞生物中的程序性细胞死亡。相对于细胞坏死,细胞凋亡是受基因调控的主动过程,细胞凋亡时会发生特征性的形态学变化,产生称为凋亡小体的细胞碎片被吞噬细胞吞噬。细胞凋亡受到促凋亡因子(Fas 受体和 caspases)和抑凋亡因子(Bcl-2蛋白和 IAP)的调控,异常凋亡过程牵涉到多种疾病中,细胞凋亡的抑制可导致癌症、自身免疫性疾病、炎性疾病和病毒感染。另一方面,过度的细胞凋亡可能导致神经退行性疾病、血液疾病和组织损伤。目前在细胞凋亡与癌症发生和自身免疫性疾病之间的关系有着很多研究,人们希望激发癌细胞的细胞凋亡,以达到治疗癌症的目的。“细胞凋亡在神经退化性疾病中所扮演的角色(如阿兹海默氏症、亨丁顿舞蹈症、帕金森病、肌肉萎缩性侧索硬化症),是目前热门的研究领域。” TargetMol 细胞凋亡化合物库精选 2394 种与凋亡相关的生物活性小分子化合物,适用于癌症和神经退行性疾病相关研究。

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产品编号 L9000

细胞凋亡化合物库

规格

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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产品描述 产品描述

  • 2394种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选;
  • 靶点含Bcl-2、Caspase、p53、TNF-α和survivin等;
  • 通过前期临床研究和临床实验,生物活性和安全性已经得到验证;
  • 其中一些活性化合物已得到FDA批准上市;
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR和HPLC检测技术保证产品高纯度和高质量;
  • 所有化合物现货供应。

Packaging And Storage | TargetMol 包装和储存

  • 可选用DMSO耐受的96/384孔板或2D 条形码编码管;
  • 干粉蓝冰运输,DMSO溶液干冰运输;
  • 排布:96孔板:1st & 12th 空白对照,384孔板:1st & 2nd & 23th & 24th空白对照。

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Library Customization | TargetMol 化合物库组成

Apoptosis
Autophagy
Endogenous Metabolite
TNF
NF-κB
Antibacterial
Ferroptosis
Caspase
EGFR
Bcl-2 Family
CDK
Reactive Oxygen Species
COX
JAK
PI3K
ERK
Akt
p38 MAPK
DNA/RNA Synthesis
STAT
VEGFR
Antibiotic
Antioxidant
IL Receptor
HDAC
p53
Raf
HIV Protease
Antifungal
Microtubule Associated
JNK
Parasite
FLT
Src
RIP kinase
mTOR
c-RET
Mitophagy
Influenza Virus
MEK
FGFR
AMPK
PERK
PARP
PDGFR
Aurora Kinase
Mdm2
Dehydrogenase
PKC
Epigenetic Reader Domain
Bcr-Abl
Topoisomerase
E1/E2/E3 Enzyme
HSP
c-Kit
MAPK
Nrf2
Proteasome
Phosphatase
PPAR
Wnt/beta-catenin
Nucleoside Antimetabolite/Analog
Ras
Histone Methyltransferase
Cytochromes P450
Interleukin
c-Met/HGFR
Virus Protease
Mitochondrial Metabolism
NO Synthase
GSK-3
Tyrosine Kinases
ROS
Lipoxygenase
PD-1/PD-L1
Pim
Calcium Channel
IAP
AChR
ADC Cytotoxin
Serine/threonin kinase
MMP
Sirtuin
HER
Estrogen/progestogen Receptor
IGF-1R
HSV
IκB/IKK
Potassium Channel
ATPase
PKA
Estrogen Receptor/ERR
PDE
Tyrosinase
c-Myc
Gamma-secretase
SARS-CoV
Beta Amyloid
Retinoid Receptor
FAK
RAAS
Cholinesterase (ChE)
Chk
DUB
TGF-beta/Smad
P-gp
TLR
Phospholipase
GABA Receptor
DNA-PK
DNA Alkylator/Crosslinker
Histamine Receptor
ALK
PDK
5-HT Receptor
S6 Kinase
HIF/HIF Prolyl-Hydroxylase
Dopamine Receptor
Integrin
Histone Demethylase
HBV
Rho
TRP/TRPV Channel
Antiviral
Prostaglandin Receptor
GPR
HIF
NOS
Cysteine Protease
Adrenergic Receptor
DNA Alkylation
Trk receptor
ASK
Casein Kinase
ATM/ATR
c-Fms
PLK
Anti-infection
HMG-CoA Reductase
TAM Receptor
HCV Protease
NADPH
Immunology/Inflammation related
BTK
Fatty Acid Synthase
Histone Acetyltransferase
Syk
Kinesin
S1P Receptor
Transferase
Glutathione Peroxidase
MAO
Glucocorticoid Receptor
Drug Metabolite
CaMK
Telomerase
Survivin
Pyroptosis
Reverse Transcriptase
Kras
DNA Methyltransferase
MRP
Aryl Hydrocarbon Receptor
iGluR
UGT
Antifection
Opioid Receptor
DAPK
Sodium Channel
Monoamine Oxidase
ROR
Adenosine Receptor
Reductase
Serine Protease
Cell Cycle Arrest
Glucokinase
ROCK
CSF-1R
Hedgehog/Smoothened
PTEN
GluR
DNA
Androgen Receptor
Lipid
OXPHOS
MNK
Free radical scavengers
transporter
GPX
NADPH-oxidase
NOD-like Receptor (NLR)
MLK
Carbonic Anhydrase
CRM1
YAP
IFNAR
BACE
DYRK
Necroptosis
Tie-2
TOPK
FXR
Leukotriene Receptor
NAMPT
IRE1
LDL
P2X Receptor
Hexokinase
DPP-4
PAK
Transketolase
PGE Synthase
Acyltransferase
STING
PAI-1
CRISPR/Cas9
Cuproptosis
SGK
NOD
ROS Kinase
Proton pump
DHFR
Amino Acids and Derivatives
LPL Receptor
LTR
VDA
Progesterone Receptor
OCT
VDAC
Hck
Antifolate
Liver X Receptor
PYK2
FOXO1
RANKL/RANK
Myosin
FLAP
PAFR
Fas/FasL
NMDAR
ABC Transporter
Glucosidase
Smo
CCR
CXCR
Endothelin Receptor
PAD
Xanthine Oxidase
KSP
cAMP
Indoleamine 2,3-Dioxygenase (IDO)
SGLT
Wee1
Beta-Secretase
LRRK2
Aminopeptidase
GST
Aromatase
Neurokinin receptor
BMI-1
IRAK
Apelin receptor
Chloride channel
PROTACs
Hydrogenase
MALT
Dynamin
P2Y Receptor
Na+/Ca2+ Exchanger
RAR/RXR 
Lipase
gp120/CD4
GTPase
Melatonin Receptor
GNRH Receptor
Amylase
IDO
SIK
MTH1
DNA gyrase
Monoamine Transporter
Guanylate cyclase
Thioredoxin
FAAH
Stearoyl-CoA Desaturase (SCD)
ACK1
Somatostatin
Epoxide Hydrolase
Norepinephrine
Glutathione reductase
AIM2
Decarboxylase
HuR
MELK
RSV
Neprilysin
Hippo pathway
Acetyl-CoA Carboxylase
Protease
LPA Receptor
KLF
PI4K
GHSR
Adenosine Deaminase
Cannabinoid Receptor
Complement System
Platelet aggregation
APC/C
cholecystokinin
Sigma receptor
Thrombin
Protease-activated Receptor
p97
AhR
CFTR
Imidazoline Receptor
PKM