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Anti-TGFBR2 Monoclonal Antibody-AF488

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产品编号 TMAZ-0192A4
别名 Transforming growth factor-beta receptor type II, TGF-beta type II receptor, TGF-beta receptor type-2

Anti-TGFBR2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.

Anti-TGFBR2 Monoclonal Antibody-AF488

Anti-TGFBR2 Monoclonal Antibody-AF488

Rating icon 还可以
产品编号 TMAZ-0192A4 别名 Transforming growth factor-beta receptor type II, TGF-beta type II receptor, TGF-beta receptor type-2

Anti-TGFBR2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.

规格价格库存数量
25 μg¥ 3,5997日内发货
50 μg¥ 5,9987日内发货
100 μg¥ 8,9977日内发货
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产品介绍

生物活性
产品描述
Anti-TGFBR2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
别名Transforming growth factor-beta receptor type II, TGF-beta type II receptor, TGF-beta receptor type-2
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of TGFBR2 overexpressed 311F cells with TMAZ-0192A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS, IF
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of TGFBR2 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways|Has transforming growth factor beta-activated receptor activity|Has transforming growth factor beta-activated receptor activity|Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1
偶联与修饰
偶联
AF488
其他可选修饰符
Biotin/APC/PE/AF555/AF647
可提供抗体种类
1
抗原信息
免疫原
TGFBR2
抗原种属
Human
基因ID
7048
Uniprot ID
研究领域
Drug Target
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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