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Anti-TGFBR2 Monoclonal Antibody-AF488
产品编号 TMAZ-0192A4
别名 TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II
Anti-TGFBR2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Anti-TGFBR2 Monoclonal Antibody-AF488
Anti-TGFBR2 Monoclonal Antibody-AF488
产品编号 TMAZ-0192A4 别名 TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II
Anti-TGFBR2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 2,087.42¥ 3,599 | 7日内发货 | |
| 50 μg | ¥ 3,478.84¥ 5,998 | 7日内发货 | |
| 100 μg | ¥ 5,218.26¥ 8,997 | 7日内发货 |
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| 产品描述 | Anti-TGFBR2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
| 别名 | TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of TGFBR2 overexpressed 311F cells with TMAZ-0192A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of TGFBR2 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways|Has transforming growth factor beta-activated receptor activity|Has transforming growth factor beta-activated receptor activity|Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1 |
| 偶联 | AF488 |
| 其他可选修饰符 | Biotin/APC/PE/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | TGFBR2 |
| 抗原种属 | Human |
| 基因ID | 7048 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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