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Anti-JAM2 Monoclonal Antibody-PE
产品编号 TMAZ-0270P
别名 Junctional adhesion molecule B, Vascular endothelial junction-associated molecule, Junctional adhesion molecule 2
Anti-JAM2 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting JAM2. Anti-JAM2 Monoclonal Antibody-PE can be used in ELISA, FACS.
Anti-JAM2 Monoclonal Antibody-PE
Anti-JAM2 Monoclonal Antibody-PE
产品编号 TMAZ-0270P 别名 Junctional adhesion molecule B, Vascular endothelial junction-associated molecule, Junctional adhesion molecule 2
Anti-JAM2 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting JAM2. Anti-JAM2 Monoclonal Antibody-PE can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,349.66¥ 2,327 | 7日内发货 | |
| 50 μg | ¥ 2,249.24¥ 3,878 | 7日内发货 | |
| 100 μg | ¥ 3,373.86¥ 5,817 | 7日内发货 |
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| 产品描述 | Anti-JAM2 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting JAM2. Anti-JAM2 Monoclonal Antibody-PE can be used in ELISA, FACS. |
| 别名 | Junctional adhesion molecule B, Vascular endothelial junction-associated molecule, Junctional adhesion molecule 2 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of JAM2 overexpressed 467F cells with TMAZ-0270P, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of JAM2 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed: 11590146, PubMed: 11823489, PubMed: 24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed: 24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed: 11590146, PubMed: 24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed: 12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed: 12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity) |
| 偶联 | PE |
| 其他可选修饰符 | Biotin/APC/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | JAM2 |
| 抗原种属 | Human |
| 基因ID | 58494 |
| Uniprot ID | |
| 研究领域 | Other Functions |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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