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Anti-ERBB4 Monoclonal Antibody-AF647
还可以产品编号 TMAZ-0124A6
别名 Tyrosine kinase-type cell surface receptor HER4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, p180erbB4
Anti-ERBB4 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting ERBB4. Anti-ERBB4 Monoclonal Antibody-AF647 can be used in ELISA, FACS.
Anti-ERBB4 Monoclonal Antibody-AF647
Anti-ERBB4 Monoclonal Antibody-AF647
还可以产品编号 TMAZ-0124A6 别名 Tyrosine kinase-type cell surface receptor HER4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, p180erbB4
Anti-ERBB4 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting ERBB4. Anti-ERBB4 Monoclonal Antibody-AF647 can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 3,599 | 7日内发货 | |
| 50 μg | ¥ 5,998 | 7日内发货 | |
| 100 μg | ¥ 8,997 | 7日内发货 |
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生物活性
偶联与修饰
抗原信息
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| 产品描述 | Anti-ERBB4 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting ERBB4. Anti-ERBB4 Monoclonal Antibody-AF647 can be used in ELISA, FACS. |
| 别名 | Tyrosine kinase-type cell surface receptor HER4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, p180erbB4 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of ERBB4 overexpressed 309F cells with TMAZ-0124A6, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | GPI-anchor |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of ERBB4 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in PBS. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis |
| 偶联 | AF647 |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555 |
| 可提供抗体种类 | 2 |
| 免疫原 | ERBB4 |
| 抗原种属 | Human |
| 基因ID | 2066 |
| Uniprot ID | |
| 研究领域 | Cancer Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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嗨！很高兴为您提供帮助！
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