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Anti-CHGA Monoclonal Antibody-AF488
产品编号 TMAZ-0139A4
别名 Chromogranin-A, Pituitary secretory protein I
Anti-CHGA Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CHGA. Anti-CHGA Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-CHGA Monoclonal Antibody-AF488
Anti-CHGA Monoclonal Antibody-AF488
产品编号 TMAZ-0139A4 别名 Chromogranin-A, Pituitary secretory protein I
Anti-CHGA Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CHGA. Anti-CHGA Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,412.3¥ 2,435 | 7日内发货 | |
| 50 μg | ¥ 2,353.64¥ 4,058 | 7日内发货 | |
| 100 μg | ¥ 3,530.46¥ 6,087 | 7日内发货 |
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| 产品描述 | Anti-CHGA Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CHGA. Anti-CHGA Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| 别名 | Chromogranin-A, Pituitary secretory protein I |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CHGA overexpressed 486F cells with TMAZ-0139A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CHGA protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Strongly inhibits glucose induced insulin release from the pancreas|Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed: 15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed: 15723172, PubMed: 24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed: 21214543). Acts as a potent scavenger of free radicals in vitro (PubMed: 24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed: 18541522)|Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation |
| 偶联 | AF488 |
| 其他可选修饰符 | Biotin/APC/PE/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | CHGA |
| 抗原种属 | Human |
| 基因ID | 1113 |
| Uniprot ID | |
| 研究领域 | Cancer Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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