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Search Results for " vascular cell "

Targets Recommended: VEGFR

83

抑制剂 & 化合物

9

天然产物

2

化合物库

77

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；
L1120	AMPK靶向分子库		80 compounds
	80 个靶向AMPK 的分子集合，可用于高通量和高内涵筛选；

化合物库

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

AMPK靶向分子库

Cat.No: L1120

Compounds: 80

Cat. No.	Product Name	Target	Signaling Pathways
T9929	Ramucirumab	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Ramucirumab 是一种人 VEGFR-2 拮抗剂，具有抗实体瘤活性。它是人源化单克隆抗体，能够与 VEGFR-2 结合，阻碍 VEGFR 配体 VEGF-A，VEGF-C 和 VEGF-D 结合。
T2456	Tivozanib 替沃扎尼,AV-951,KRN951	VEGFR; PDGFR; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Tivozanib (KRN951) 是一种选择性的 VEGFR 1/2/3抑制剂，它们的 IC50值分别为0.21 nM、0.16 nM、0.24 nM。
T7123	AMG-47a	VEGFR; p38 MAPK; JAK; Src	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors
	AMG-47a 是具有口服活性的 Lck 抑制剂，IC50值为 0.2 nM。它具有抗炎作用，对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。
T25340	Diprotin A Ile-Pro-Ile,抑二肽素A	DPP-4	Proteases/Proteasome
	Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
T1057	Azilsartan TAK-536,阿齐沙坦	RAAS	Endocrinology/Hormones
	Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。
T1792L	Regorafenib monohydrate	Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib monohydrate 是一种新型口服多激酶抑制剂，对VEGFR1/2/3、PDGFRβ、Kit、RET 和Raf-1的IC50分别为 13、4.2、46、22、7、1.5 和 2.5 nM。
T6351	MGCD-265 analog MGCD-265,Glesatinib	Apoptosis; VEGFR; c-Met/HGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	MGCD-265 analog (Glesatinib) 是一种口服生物可利用的多靶点酪氨酸激酶抑制剂，具有抗肿瘤活性，对 c-Met 和 VEGFR2 的 IC50 分别为 29 nM 和 10 nM。
T1792	Regorafenib BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼	Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂，抑制 RET、C-RAF、VEGFR2、c-Kit、VEGFR1 和 PDGFRβ (IC50=1.5/2.5/4.2/7/13/22 nM)，具有口服活性。Regorafenib 具有抗肿瘤和抗血管生成活性。
T2514	Linifanib 利尼伐尼,ABT-869,RG3635,AL-39324	Apoptosis; c-Fms; VEGFR; FLT; CSF-1R; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; Tyrosine Kinase/Adaptors
	Linifanib (AL-39324) 是一种高效口服的VEGFR 和PDGFR 家族多靶点抑制剂，具有显著的抗肿瘤活性。它对无关 RTKs、可溶性酪氨酸激酶或丝氨酸/苏氨酸激酶的活性要低得多。它是特异性 miR-10b 抑制剂，阻断miR-10b 的生物合成。
T34280	Regrelor disodium INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589	P2Y Receptor	GPCR/G Protein; Neuroscience
	Regrelor disodium (INS 50589) 是一种 p2y12 受体拮抗剂，可预防血栓形成，可有效抑制血管平滑肌细胞收缩，抑制细胞增殖，减少炎症。
T11742	K-7174	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	K-7174 是一种新型细胞粘附抑制剂，抑制由 IL-1β 或 TNF-α 诱导的血管细胞粘附分子 1 (VCAM-1) 的表达。
T3977L	Lifitegrast sodium SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra	Others	Others
	Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel
T1608	ADH-1 trifluoroacetate Exherin trifluoroacetate	Dehydrogenase	Metabolism
	ADH-1 trifluoroacetate (Exherin trifluoroacetate) 是一种选择性的、竞争性N-钙粘蛋白拮抗剂，具有潜在抗肿瘤和抗血管生成作用。
T8857	LJP-1586 HCl LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586	Others	Others
	LJP-1586 HCl 是一种高选择性的血管粘附蛋白-1（VAP-1）抑制剂，通过减少脑出血（ICH）后粘附分子表达和免疫细胞浸润而显示出抗炎作用。
T68455	AP23846 AP-23846	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	AP23846 是一种新型高效的 Src 家族激酶抑制剂，可降低人实体瘤细胞系中血管内皮生长因子和白细胞介素-8 的表达，并消除下游血管生成过程。
T68002L	(R)-Naroparcil	Others	Others
	(R)-Naroparcil 是 Naroparcil 的异构体。 Naroparcil 是一种4-甲基伞形酮基 β-D-木糖苷类似物，与血管平滑肌细胞增殖有关，在 Wessler 淤滞模型中抑制血栓的形成。
T2576	Brivanib (alaninate) 丙氨酸布立尼布,BMS-582664,Brivanib Alaninate	VEGFR; FGFR; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	Brivanib Alaninate (BMS-582664) 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐，IC50值为 25 nM，具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制，对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。
T2064	Semaxinib 司马沙尼,SU5416	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Semaxinib (SU5416) 是一种选择性的 VEGFR(Flk-1/KDR) 抑制剂，其 IC50=1.23 μM。
T6517	Golvatinib E-7050,戈伐替尼	VEGFR; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Golvatinib (E-7050) 是一种 c-Met (IC50:14 nM) 和 VEGFR2 (IC50:16 nM) 的双重抑制剂。
T9659	LCB 03-0110 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	LCB 03-0110 (3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol) 是一种盘状结构域受体家族酪氨酸激酶的强效抑制剂，可强烈抑制多种酪氨酸激酶，包括 c-Src 家族、脾酪氨酸激酶、布鲁顿酪氨酸激酶和血管内皮生长因子受体 2，它们对免疫很重要细胞信号传导和炎症反应。
T60396	JMS-053	Phosphatase	Metabolism
	JMS-053 是一种具有有效性和选择性的磷酸酶 DUSP3 抑制剂，抑制 PTP4A3、 PTP4A1 、 PTP4A2 和 CDC25B，抑制癌细胞迁移和球体生长，避免血管内皮生长因子或脂多糖对微血管内皮屏障功能的破坏。
T2511	Plinabulin 普那布林,NPI-2358	Microtubule Associated	Cytoskeletal Signaling
	Plinabulin (NPI-2358) 是一种抗微管蛋白解聚肿瘤细胞的血管破坏剂，选择性地靶向并结合到微管蛋白的秋水仙碱结合位点，从而中断微管动力学的平衡。它对人肿瘤细胞系具有抑制作用，对 HT-29 细胞系的IC50值为 9.8 nM。
T67749	Fuzapladib IS-741	Phospholipase	Metabolism
	Fuzapladib (IS-741) (IS-741)是一种磷脂酶A2抑制剂，可以抑制细胞粘附分子Mac-1的表达。fuzpladib 阻断炎症细胞表面表达的粘附分子(integrin)的激活，阻止炎症细胞粘附血管内皮细胞和浸润组织，控制胰腺炎的恶化。
T2624	OSI-930 OSI 930,噻尔非尼	Apoptosis; c-Fms; Raf; VEGFR; FLT; CSF-1R; Src; c-Kit	Angiogenesis; Apoptosis; MAPK; Tyrosine Kinase/Adaptors
	OSI-930 是 Kit，KDR 和 CSF-1R (c-Fms)的口服选择性抑制剂，IC50分别为 80 nM，9 nM 和 15 nM。它具有抗肿瘤活性，靶向肿瘤中的癌细胞增殖和血管生成。它还适度抑制 Flt-1，c-Raf 和 Lck，并且对 PDGFRα/β，Flt-3和 Abl 具有较弱的抑制活性。
T29067	Upacicalcet PLS-240,SK-1403,AJT-240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Upacicalcet (AJT-240) 是一种静脉内拟钙剂，是一种可用于人血液透析的 SHPT，通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂，可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。
T77401	Bavituximab Anti-PS MAb 3G4	Others	Others
	Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) 是一种针对磷脂酰丝氨酸 (PS) 的单克隆抗体，具有血管靶向和免疫调节特性，能够重新激活抗肿瘤免疫来抑制肿瘤生长。Bavituximab 具有抗癌活性，常联合Paclitaxel 和 Carboplatin 来研究非小细胞肺癌。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T19710	Ciglitazone Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis; p38 MAPK; PPAR	Apoptosis; DNA Damage/DNA Repair; MAPK; Metabolism
	Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50：3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化，降低胰岛素水平、血管内皮生长因子的产生和血压，诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡，激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T21547	PAF (C16) C16-PAF	ERK; MEK; MAPK; Endogenous Metabolite	MAPK; Metabolism
	PAF (C16) 是有效的 MAPK 和 MEK/ERK 激活剂，可诱导血管通透性增加。PAF (C16) (PAF (C16)) 是血小板活化因子，是一种磷脂衍生介质，也是 PAF G 蛋白偶联受体 (PAFR) 的配体。PAF (C16) 在体外实验中显示出抗凋亡和抗炎活性，通过与其受体（PAF-R）相互作用以执行细胞信号传导来抑制 caspase 依赖性凋亡。
T2160	Suramin Sodium Salt 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060	Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K，是抗寄生虫，抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂，也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。
T3979	Emedastine LY188695,依美斯汀,Emadine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Emedastine (LY188695) 是一种可口服的，选择性和高亲和力的组胺 H1受体拮抗剂，Ki 值为 1.3 nM。它是苯并咪唑衍生物，可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。
T24858	TBZ-07	Others	Others
	TBZ-07 is an anti-angiogenesis and vascular disrupting agent that acts by exhibiting moderate inhibitory cell proliferation activity.
T31072	CP-664511 UNII-W1AEF8025F,CP664511	Others	Others
	CP-664511 is an alpha4beta1/ vascular cell adhesion molecule-1 (VCAM-1) inhibitor with therapeutic potential for allergic airway disease.
T15746	Lexibulin dihydrochloride CYT-997 dihydrochloride	Others	Others
	Lexibulin 2Hcl is an effective tubulin polymerization inhibitor (IC50: 10-100 nM in cancer cell lines). It also has potent cytotoxic and vascular disrupting activity in vitro and in vivo.
T71292	Rivipansel sodium	Others	Others
	Rivipansel sodium is a glycomimetic drug candidate that acts as a pan-selectin antagonist and reverses acute vascular occlusions in sickle cell mice.
T2500L	Cediranib maleate AZD-2171,Recentin,西地尼布马来酸盐,AZD2171,AZD2171 maleate,AZD 2171	Others	Others
	Cediranib is a potent and selective inhibitor of VEGF with antineoplastic activities. It inhibits all three vascular endothelial growth factor receptor (VEGF-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.
T68708	Denibulin HCl	Others	Others
	Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.
T26095	Rivipansel GMI1070,GMI-1070,PF 06460031,GMI 1070,PF-06460031	Others	Others
	Rivipansel is a glycomimetic compound. It acts as a pan-selectin antagonist and reverses acute vascular occlusions in sickle cell mice.
T37037	Vinflunine ditartrate	Others	Others
	Vinflunine ditartrate, a fluorinated microtubule inhibitor and member of the Vinca alkaloids family, exhibits anti-angiogenic, vascular-disrupting, and anti-metastatic properties. It presents a potential avenue for studying transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and breast carcinoma[1][2].
T69203	HMR1031	Others	Others
	HMR1031 is a potent and specific integrin α4ß1 or very late antigen 4 (VLA-4) receptor antagonist which binds to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin.
T40596	Tasisulam sodium LY 573636 sodium,Tasisulam sodium	Others	Others
	Tasisulam is an anti-cancer compound that induces apoptosis through the intrinsic pathway, leading to the release of cytochrome c and caspase-dependent cell death. Additionally, tasisulam inhibits mitotic progression and triggers vascular normalization.
T70211	CAM741
	CAM741 is a novel selective inhibitor of vascular cell adhesion molecule 1 (VCAM1) synthesis in endothelial cells, blocking the process of cotranslational translocation, which is dependent on the signal peptide of VCAM1.
T68273	BNC105P	Others	Others
	BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, deprivi...
T38935	Cu(II) protoporphyrin IX	Others	Others
	Cu (II) Protoporphyrin IX functions as a negative control for Zn (II) Protoporphyrin, a heme oxygenase inhibitor. Heme oxygenase is involved in tumor cell resistance to chemotherapy and the regulation of free radical formation, inflammation, and vascular repair.
T37595	Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt)
	Brain-derived acidic fibroblast growth factor (brain-derived aFGF) (1-11) is a peptide fragment of brain-derived aFGF. Brain-derived aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. aFGF (1-11) corresponds to amino acid residues 1-11 of the full length peptide.
T80152	Protein LMWP	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Protein LMWP为具有血管内皮生长因子(VEGF)抑制活性的细胞穿透肽，能够抑制肿瘤生长，适用于癌症研究领域。
T36214	16,16-dimethyl Prostaglandin E1 16,16-dimethyl Prostaglandin E1	Others	Others
	16,16-dimethyl Prostaglandin E1 是 PGE1 (T1626) 类似物，可诱导支气管收缩和血管平滑肌收缩，并抑制吲哚美辛诱导的细胞伸长。
T35585	I-BOP	Others	Others
	I-BOP 是血栓素 A2 受体 (TP) 的激动剂（KD=0.61 nM）。I-BOP 可通过激活血管平滑肌中的 PI3K 通路促进细胞增殖。
T37079	VEGFR2 Kinase Inhibitor II	Others	Others
	Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2's kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. V...

化合物

Cat.No: T9929

Target: VEGFR

Cat.No: T2456

Synonym: 替沃扎尼,AV-951,KRN951

Target: VEGFR, PDGFR, Ephrin Receptor

Cat.No: T7123

Target: VEGFR, p38 MAPK, JAK, Src

Cat.No: T25340

Synonym: Ile-Pro-Ile,抑二肽素A

Target: DPP-4

Cat.No: T1057

Synonym: TAK-536,阿齐沙坦

Target: RAAS

Regorafenib monohydrate

Cat.No: T1792L

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

MGCD-265 analog

Cat.No: T6351

Synonym: MGCD-265,Glesatinib

Target: Apoptosis, VEGFR, c-Met/HGFR

Cat.No: T1792

Synonym: BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Cat.No: T2514

Synonym: 利尼伐尼,ABT-869,RG3635,AL-39324

Target: Apoptosis, c-Fms, VEGFR, FLT, CSF-1R, PDGFR, c-Kit, Autophagy

Regrelor disodium

Cat.No: T34280

Synonym: INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589

Target: P2Y Receptor

Cat.No: T11742

Target: IL Receptor, TNF

Lifitegrast sodium

Cat.No: T3977L

Synonym: SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra

Target: Others

ADH-1 trifluoroacetate

Cat.No: T1608

Synonym: Exherin trifluoroacetate

Target: Dehydrogenase

Cat.No: T8857

Synonym: LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586

Target: Others

Cat.No: T68455

Synonym: AP-23846

Target: Src

Cat.No: T68002L

Target: Others

Brivanib (alaninate)

Cat.No: T2576

Synonym: 丙氨酸布立尼布,BMS-582664,Brivanib Alaninate

Target: VEGFR, FGFR, Autophagy

Cat.No: T2064

Synonym: 司马沙尼,SU5416

Target: VEGFR

Cat.No: T6517

Synonym: E-7050,戈伐替尼

Target: VEGFR, c-Met/HGFR

Cat.No: T9659

Synonym: 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol

Target: Discoidin Domain Receptor (DDR)

Cat.No: T60396

Target: Phosphatase

Cat.No: T2511

Synonym: 普那布林,NPI-2358

Target: Microtubule Associated

Cat.No: T67749

Synonym: IS-741

Target: Phospholipase

Cat.No: T2624

Synonym: OSI 930,噻尔非尼

Target: Apoptosis, c-Fms, Raf, VEGFR, FLT, CSF-1R, Src, c-Kit

Cat.No: T29067

Synonym: PLS-240,SK-1403,AJT-240

Target: Calcium Channel

Cat.No: T77401

Synonym: Anti-PS MAb 3G4

Target: Others

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

Cat.No: T19710

Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Target: Apoptosis, p38 MAPK, PPAR

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

Cat.No: T21547

Synonym: C16-PAF

Target: ERK, MEK, MAPK, Endogenous Metabolite

Suramin Sodium Salt

Cat.No: T2160

Synonym: 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

Cat.No: T3979

Synonym: LY188695,依美斯汀,Emadine

Target: Histamine Receptor

Cat.No: T24858

Target: Others

Cat.No: T31072

Synonym: UNII-W1AEF8025F,CP664511

Target: Others

Lexibulin dihydrochloride

Cat.No: T15746

Synonym: CYT-997 dihydrochloride

Target: Others

Rivipansel sodium

Cat.No: T71292

Target: Others

Cediranib maleate

Cat.No: T2500L

Synonym: AZD-2171,Recentin,西地尼布马来酸盐,AZD2171,AZD2171 maleate,AZD 2171

Target: Others

Cat.No: T68708

Target: Others

Cat.No: T26095

Synonym: GMI1070,GMI-1070,PF 06460031,GMI 1070,PF-06460031

Target: Others

Vinflunine ditartrate

Cat.No: T37037

Target: Others

Cat.No: T69203

Target: Others

Tasisulam sodium

Cat.No: T40596

Synonym: LY 573636 sodium,Tasisulam sodium

Target: Others

Cat.No: T70211

Cat.No: T68273

Target: Others

Cu(II) protoporphyrin IX

Cat.No: T38935

Target: Others

Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt)

Cat.No: T37595

Cat.No: T80152

Target: VEGFR

16,16-dimethyl Prostaglandin E1

Cat.No: T36214

Synonym: 16,16-dimethyl Prostaglandin E1

Target: Others

Cat.No: T35585

Target: Others

VEGFR2 Kinase Inhibitor II

Cat.No: T37079

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0853	Adenosine 腺苷,D-Adenosine,Adenine riboside	Apoptosis; Nucleoside Antimetabolite/Analog; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Adenosine (D-Adenosine) 是一种核糖核苷，由与核糖结合的腺嘌呤组成，具有血管扩张、抗心律失常和镇痛作用。
T3427	Polydatin Piceid,虎杖苷,Polydotin Peceid	Apoptosis; Mitophagy; NF-κB; Autophagy	Apoptosis; Autophagy; NF-κB
	Polydatin (Piceid) 是从传统中药虎杖根中提取的一种天然产物，在多个实验模型中具有抗炎作用。它可抑制 G6PD，并诱导氧化和内质网应激。
T6S1784	Brazilin Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素	Apoptosis; Others; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	Brazilin (Braziletto) 是来自几种热带硬木的心材的一种红色染料前体，有软骨保护和抗炎活性。它抑制细胞增殖，促进细胞凋亡并通过 AMPK/mTOR 途径诱导自噬。
TN1042	Chebulic acid	Others	Others
	Chebulic acid 是一种分离自Terminalia chebula 中的酚羧酸化合物，具有显著的抗氧化作用，它能够打破由晚期糖基化终产物 (AGEs) 诱导的蛋白质交联，阻碍 AGEs 的形成。它能够有效控制代谢参数升高、氧化应激和肾损害，支持其在糖尿病肾病中的有益作用。
TN2354	Methylnissolin 3-Hydroxy-9,10-dimethoxyptercarpan,黄芪紫檀烷,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷	ERK; PDGFR	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	Methylnissolin 是从黄芪中分离的一种天然产物，可抑制血小板衍生生长因子 (PDGF)-BB 诱导的细胞增殖，IC50为 10 μM。。它通过抑制ERK1/2MAP 激酶级联反应抑制 PDGF-BB 诱导的血管平滑肌细胞增殖。它还抑制 PDGF-BB 诱导的细胞外信号调节激酶 1/2 (ERIC1/2) 丝裂原活化蛋白 (MAP) 激酶的磷酸化，具有抗菌和抗癌作用。
T37974	(S)-Coriolic acid 13(S)-HODE	Lipoxygenase; Mitochondrial Metabolism; PPAR	DNA Damage/DNA Repair; Metabolism
	(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂，是亚油酸与植物和哺乳动物脂氧合酶反应生成的，在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时，它能抑制肿瘤细胞与血管内皮的粘附，能下调 IRGpIIb/IIIa 受体的表达。(S)-Coriolic acid 是15-脂氧合酶 (15-LOX) 代谢产物，常作为内源性配体激活 PPARγ。(S)-Coriolic acid 诱导线粒体功能障碍和气道上皮损伤。
T35614	D-Trimannuronic acid	Others	Others
	D-Trimannuronic acid is an alginate oligomer that originates from seaweed. It can induce TNF-α secretion by mouse macrophage cell lines, making it valuable in pain and vascular dementia research [1][2][3].
T36513	Pyranonigrin A	Others	Others
	Pyranonigrin A is a fungal metabolite originally isolated from Aspergillus that has antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH;) free radicals in a cell-free assay (IC50 = 132.9 μM). Pyranonigrin A (10 μM) suppresses TNF-α-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs).
TN3409	Anagyrine	Antifection	Microbiology/Virology
	Anagyrine, is the responsible teratogen from teratogenic lupins, can produce congenital deformities in calves typical of crooked calf disease; it also can induce red cell aplasia, vascular anomaly, and skeletal dysplasia.(-)-Anagyrine and (-)--Methylcytisine have nematicidal activities against Pine Wood Nematodes.

天然产物

Cat.No: T0853

Synonym: 腺苷,D-Adenosine,Adenine riboside

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Endogenous Metabolite, Autophagy

Cat.No: T3427

Synonym: Piceid,虎杖苷,Polydotin Peceid

Target: Apoptosis, Mitophagy, NF-κB, Autophagy

Cat.No: T6S1784

Synonym: Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素

Target: Apoptosis, Others, AMPK, Autophagy

Cat.No: TN1042

Target: Others

Cat.No: TN2354

Synonym: 3-Hydroxy-9,10-dimethoxyptercarpan,黄芪紫檀烷,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷

Target: ERK, PDGFR

(S)-Coriolic acid

Cat.No: T37974

Synonym: 13(S)-HODE

Target: Lipoxygenase, Mitochondrial Metabolism, PPAR

D-Trimannuronic acid

Cat.No: T35614

Target: Others

Cat.No: T36513

Target: Others

Cat.No: TN3409

Target: Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01830	VCAM-1 Protein, Mouse, Recombinant (His) Vcam-1,CD106,vascular cell adhesion molecu...	Mouse	HEK293 Cells
	VCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 75.8 kDa and the accession number is Q3UPN1.
TMPY-00947	VCAM-1 Protein, Human, Recombinant (hFc) INCAM-100,CD106,VCAM-1,vascular cell adhes...	Human	HEK293 Cells
	VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1.
TMPJ-00603	TL1A/TNFSF15 Protein, Mouse, Recombinant TNFSF15,Tumor Necrosis Factor Ligand Superfamily Member 15,V...	Mouse	E. coli
	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial ...
TMPJ-00930	VCAM-1 Protein, Mouse, Recombinant (hFc) Vascular cell adhesion protein 1,Vcam1	Mouse	HEK293 Cells
	Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interac...
TMPH-03398	VCAM-1 Protein, Rat, Recombinant (His) Vcam1,Vascular cell adhesion protein 1	Rat	E. coli
	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM-1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 77.4 ...
TMPY-01144	VCAM-1 Protein, Mouse, Recombinant (His & hFc) vascular cell adhesion molecule 1,Vcam-1,C...	Mouse	HEK293 Cells
	VCAM-1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 102 kDa and the accession number is Q3UPN1.
TMPY-05616	VCAM-1 Protein, Human, Recombinant (hFc), Biotinylated CD106,vascular cell adhesion molecule 1,IN...	Human	HEK293 Cells
	VCAM-1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P19320-1.
TMPY-06916	VCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated vascular cell adhesion molecule 1,INCAM-10...	Human	HEK293 Cells
	VCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 77.36 kDa and the accession number is NP_001069.1.
TMPY-00948	VCAM-1 Protein, Human, Recombinant (His) vascular cell adhesion molecule 1,CD106,IN...	Human	HEK293 Cells
	VCAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76 kDa and the accession number is P19320-1.
TMPJ-00377	VCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated INCAM-100,Vascular cell adhesion protein 1...	Human	HEK293 Cells
	VCAM-1 (CD106, INCAM-110) is a cell adhesion molecule and a member of the immunoglobulin superfamily. It's important function is a recognition of cell-cell. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation。
TMPJ-00865	VEGF121 Protein, Human, Recombinant (His) VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生...	Human	HEK293 Cells
	Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPK-00810	tPA Protein, Mouse, Recombinant (His) PLAT,Reteplase,t-PA,tPA,Alteplase	Mouse	HEK293 Cells
	Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism.
TMPJ-00864	VEGF165 Protein, Human, Recombinant Vascular Endothelial Growth Factor Isoform 165,血管内皮...	Human	HEK293 Cells
	Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul...
TMPJ-00412	VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) Vascular endothelial growth factor receptor 1,V...	Human	HEK293 Cells
	Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas...
TMPJ-00562	PDGF-BB Protein, Mouse, Recombinant (His) PDGFBB,PDGF-BB,血小板源生长因子	Mouse	E. coli
	Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor，it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival...
TMPH-02568	CTGF/CCN2 Protein, Mouse, Recombinant (GST) betaIG-M2,Connective tissue growth factor,Protein FISP-12,Fi...	Mouse	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
TMPK-00359	Endoglin/CD105 Protein, Human, Recombinant (His & Avi) CD105,ORW,ORW1,ENG,END,Endoglin,HHT1	Human	HEK293 Cells
	Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response...
TMPK-00558	BCAM Protein, Cynomolgus, Recombinant (His) CD239,MSK19,Lutheran,Gplu,LU	Cynomolgus	HEK293 Cells
	Lutheran/basal cell adhesion molecule (Lu/BCAM) is a transmembrane adhesion molecule expressed by erythrocytes and endothelial cells that can interact with the extracellular matrix protein laminin-α5. In sickle cell disease, Lu/BCAM is thought to contribute to adhesion of sickle erythrocytes to the vascular wall, especially during vaso-occlusive crises.
TMPK-00489	TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) TNFSF15,TNF superfamily member 15,TL1,VEGI192A,TL1A,VEGI-251...	Cynomolgus,Rhesus	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weigh...
TMPK-00645	VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) KRD1,VEGFR2,FLK1,CD309,Ly73,VEGFR,VEGFR-21,KDR	Rhesus	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with ...
TMPH-01069	CTGF/CCN2 Protein, Human, Recombinant (His) Hypertrophic chondrocyte-specific protein 24,CCN family memb...	Human	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. CTGF/CCN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.1 kDa and...
TMPK-00143	TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag) TL1A,TL1,TNFSF15,VEGI,VEGI192A,VEGI-251	Human	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight...
TMPK-00978	ECSCR Protein, Human, Recombinant (hFc) ECSM2,ECSCR,ARIA	Human	HEK293 Cells
	Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC...
TMPY-01910	TIE1 Protein, Human, Recombinant (His) tyrosine kinase with immunoglobulin-like and EGF-like domain...	Human	HEK293 Cells
	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appear...
TMPK-00830	P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated FLJ45155,CD62P,GRMP,CD62,P-Selectin,PSEL,GMP140,LECAM3,SELP,...	Human	HEK293 Cells
	Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.
TMPJ-00407	ROBO4 Protein, Human, Recombinant (hFc) Magic roundabout,Roundabout homolog 4,UNQ421/PRO3674,ROBO4	Human	HEK293 Cells
	Roundabout homolog 4(ROBO4) contains 2 fibronectin type-III domains, 2 Ig-like C2-type (immunoglobulin-like) domains and belongs to the immunoglobulin superfamily.The protein is a receptor for slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins.
TMPK-00562	CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His) FLJ58394,PECAM-1,GPIIA',FLJ34100,EndoCAM,PECA1,CD31	Cynomolgus	HEK293 Cells
	Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 65.30 kDa and the accession number is A0A7N9CHZ3.
TMPH-03241	Angiopoietin-2 Protein, Rat, Recombinant (E. coli, His) Angpt2,Angiopoietin-2,ANG-2	Rat	E. coli
	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin-2 Protein,...
TMPK-00833	CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc) FLJ34100,EndoCAM,PECA1,PECAM-1,FLJ58394,GPIIA',CD31	Human	HEK293 Cells
	Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 91.2 kDa and the accession number is P16284-1.
TMPK-00834	CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His) PECAM-1,FLJ58394,GPIIA',PECA1,EndoCAM,FLJ34100,CD31	Human	HEK293 Cells
	Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 65.6 kDa and the accession number is P16284-1.
TMPK-00454	VEGFR2/KDR Protein, Human, Recombinant (His & Avi) VEGFR-21,Ly73,KRD1,VEGFR2,CD309,FLK1,VEGFR,KDR	Human	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-H...
TMPK-00988	ECSCR Protein, Mouse, Recombinant (hFc) ECSCR,ARIA,ECSM2	Mouse	HEK293 Cells
	Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC...
TMPH-03240	Angiopoietin-2 Protein, Rat, Recombinant (His) Angiopoietin-2,Angpt2,ANG-2	Rat	Baculovirus Insect Cells
	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin-2 Protein,...
TMPY-01843	SEMA6A Protein, Human, Recombinant (His) HT018,VIA,sema domain, transmembrane domain (TM), and cytopl...	Human	HEK293 Cells
	SEMA6A, the first identified class 6 semaphorin, is contributed to regulate vascular development and adult angiogenesis. SEMA6A could inhibit proliferation, migration, and invasion in different glioma cell lines. That SEMA6A may be a potential prognostic biomarker in the treatment of GBM. Among different semaphorins tested by reverse transcriptase-polymerase chain reaction in human immune cells, the expression of class 6 transmembrane semaphorin SEMA6A was restricted to dendritic cells (DCs).
TMPK-00138	CXCL16 Protein, Mouse, Recombinant (hFc) SR-PSOX,SCYB16,SRPSOX,CXCLG16,CXCL16	Mouse	HEK293 Cells
	CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro...
TMPJ-00349	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O...	Human	HEK293 Cells
	Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive...
TMPH-02922	SRPX2 Protein, Mouse, Recombinant (His & Myc) Sushi repeat-containing protein SRPX2,Srpx2	Mouse	Baculovirus Insect Cells
	Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. SRPX2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N...
TMPK-00469	CXCL16 Protein, Human, Recombinant (hFc) SR-PSOX,SCYB16,CXCL16,CXCLG16,SRPSOX	Human	HEK293 Cells
	CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro...
TMPK-00350	E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated CD62E,ELAM,SELE,selectin E,LECAM2,ESEL,RP1-117P20.2,ELAM1,E-...	Human	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated is expre...
TMPH-02923	SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO) Srpx2,Sushi repeat-containing protein SRPX2	Mouse	E. coli
	Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli expression syste...
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc) KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti...
TMPJ-00230	EFNB1 Protein, Mouse, Recombinant (hFc & His) EFNB1,LERK-2,EPH-related receptor tyrosine kinase ligand 2,E...	Mouse	HEK293 Cells
	Mouse Ephrin-B1 is a single-pass type I membrane protein which belongs to the ephrin family. It contains an ephrin RBD (ephrin receptor-binding) domain, and expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Ephrin-B1 is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. It binds promiscuously Eph receptors residing on...
TMPK-00487	E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) selectin E,ELAM,ESEL,SELE,E-Selectin,LECAM2,CD62E,ELAM1	Cynomolgus	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) is expressed...
TMPK-00349	E-Selectin/CD62E Protein, Human, Recombinant (His & Avi) ESEL,RP1-117P20.2,CD62E,ELAM,ELAM1,selectin E,E-Selectin,LEC...	Human	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-Selectin/CD62E Protein, Human, Recombinant (His & Avi) is expressed in HEK293...
TMPY-00450	H Cadherin Protein, Mouse, Recombinant (His) Cdht,T-cadherin,cadherin 13,4932416G01Rik,Tcad	Mouse	HEK293 Cells
	CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri...
TMPY-03798	H Cadherin Protein, Rat, Recombinant (His) cadherin 13	Rat	HEK293 Cells
	CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri...
TMPY-00601	H Cadherin Protein, Mouse, Recombinant (hFc) Tcad,T-cadherin,4932416G01Rik,cadherin 13,Cdht	Mouse	HEK293 Cells
	CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri...
TMPY-03948	H Cadherin Protein, Rat, Recombinant cadherin 13	Rat	HEK293 Cells
	CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri...
TMPJ-00403	EphB1 Protein, Human, Recombinant (hFc) EPHT2,EPH Tyrosine Kinase 2,EK6,Tyrosine-Protein Kinase Rece...	Human	HEK293 Cells
	Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile α motif) domain. EPHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule i...
TMPJ-00264	LAMP1 Protein, Human, Recombinant (hFc) LAMP-1,CD107a,Lysosome-Associated Membrane Glycoprotein 1,LA...	Human	HEK293 Cells
	Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal sto...
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重组蛋白

VCAM-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01830

Species: Mouse

Expression System: HEK293 Cells

VCAM-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00947

Species: Human

Expression System: HEK293 Cells

TL1A/TNFSF15 Protein, Mouse, Recombinant

Cat.No: TMPJ-00603

Species: Mouse

Expression System: E. coli

VCAM-1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00930

Species: Mouse

Expression System: HEK293 Cells

VCAM-1 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03398

Species: Rat

Expression System: E. coli

VCAM-1 Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-01144

Species: Mouse

Expression System: HEK293 Cells

VCAM-1 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05616

Species: Human

Expression System: HEK293 Cells

VCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06916

Species: Human

Expression System: HEK293 Cells

VCAM-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00948

Species: Human

Expression System: HEK293 Cells

VCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00377

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00865

Species: Human

Expression System: HEK293 Cells

tPA Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00810

Species: Mouse

Expression System: HEK293 Cells

VEGF165 Protein, Human, Recombinant

Cat.No: TMPJ-00864

Species: Human

Expression System: HEK293 Cells

VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00412

Species: Human

Expression System: HEK293 Cells

PDGF-BB Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00562

Species: Mouse

Expression System: E. coli

CTGF/CCN2 Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02568

Species: Mouse

Expression System: E. coli

Endoglin/CD105 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00359

Species: Human

Expression System: HEK293 Cells

BCAM Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00558

Species: Cynomolgus

Expression System: HEK293 Cells

TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00489

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00645

Species: Rhesus

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01069

Species: Human

Expression System: E. coli

TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00143

Species: Human

Expression System: HEK293 Cells

ECSCR Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00978

Species: Human

Expression System: HEK293 Cells

TIE1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01910

Species: Human

Expression System: HEK293 Cells

P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPK-00830

Species: Human

Expression System: HEK293 Cells

ROBO4 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00407

Species: Human

Expression System: HEK293 Cells

CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00562

Species: Cynomolgus

Expression System: HEK293 Cells

Angiopoietin-2 Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPH-03241

Species: Rat

Expression System: E. coli

CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc)

Cat.No: TMPK-00833

Species: Human

Expression System: HEK293 Cells

CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His)

Cat.No: TMPK-00834

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00454

Species: Human

Expression System: HEK293 Cells

ECSCR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00988

Species: Mouse

Expression System: HEK293 Cells

Angiopoietin-2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03240

Species: Rat

Expression System: Baculovirus Insect Cells

SEMA6A Protein, Human, Recombinant (His)

Cat.No: TMPY-01843

Species: Human

Expression System: HEK293 Cells

CXCL16 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00138

Species: Mouse

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)

Cat.No: TMPJ-00349

Species: Human

Expression System: HEK293 Cells

SRPX2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02922

Species: Mouse

Expression System: Baculovirus Insect Cells

CXCL16 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00469

Species: Human

Expression System: HEK293 Cells

E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00350

Species: Human

Expression System: HEK293 Cells

SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02923

Species: Mouse

Expression System: E. coli

CD117 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00402

Species: Human

Expression System: HEK293 Cells

EFNB1 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00230

Species: Mouse

Expression System: HEK293 Cells

E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His)

Cat.No: TMPK-00487

Species: Cynomolgus

Expression System: HEK293 Cells

E-Selectin/CD62E Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00349

Species: Human

Expression System: HEK293 Cells

H Cadherin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00450

Species: Mouse

Expression System: HEK293 Cells

H Cadherin Protein, Rat, Recombinant (His)

Cat.No: TMPY-03798

Species: Rat

Expression System: HEK293 Cells

H Cadherin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00601

Species: Mouse

Expression System: HEK293 Cells

H Cadherin Protein, Rat, Recombinant

Cat.No: TMPY-03948

Species: Rat

Expression System: HEK293 Cells

EphB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00403

Species: Human

Expression System: HEK293 Cells

LAMP1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00264

Species: Human

Expression System: HEK293 Cells

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Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0124	Brivanib Alaninate-d4
	Brivanib Alaninate-d4 是 Brivanib Alaninate 的氘代化合物。Brivanib Alaninate 的 CAS 号为 649735-63-7。Brivanib alaninate 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐，IC50值为 25 nM，具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制，对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。

同位素标记化合物

Brivanib Alaninate-d4

Cat.No: TMIH-0124

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