143
6
53
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T81589 |
OVA-A2 Peptide
SAINFEKL, OVA (257-264) Variant |
||
OVA-A2 Peptide(SAINFEKL, OVA (257-264) Variant)是具备生物活性的A2肽(SAINFEKL)变体,具有抗原特性。 | |||
T83852 |
EGFRvIII Peptide TFA
PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide |
||
EGFRvIII peptide是一种合成肽,对应于特异性肿瘤、具有持续激活性的EGFR变体EGFRvIII的融合接头,该变体缺少野生型EGFR的第6至273个氨基酸。在25 µg/ml的浓度下,它能与MHC I类亚型HLA-A*0201阳性的T2细胞结合。在用于分离的人外周血单个核细胞(PBMCs)衍生的树突状细胞中,EGFRvIII peptide可诱导抗原呈递,进而刺激CD8+细胞毒性T淋巴细胞的激活和IFN-γ产生。与toll样受体5(TLR5)激动剂鞭毛蛋白B共同免疫EGFRvIII peptide(15 µg/动物),在正交GL261胶质母细胞瘤小鼠异种移植模型中,增加了CD8+ T细胞数量,减少了调节性T细胞(Tregs)数量,减少了肿瘤体积,并提高了生存率。 | |||
T9716 |
Ensitrelvir
S-217622 |
SARS-CoV | Microbiology/Virology |
Ensitrelvir (S-217622) 是首个口服有效的、非共价的、非肽的SARS-CoV-2 3CL 蛋白酶抑制剂,IC50为13 nM。 | |||
T7904 |
SR 19881
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
SR 19881 是 ERRγ 的完全激动剂(结合试验中的 EC50 值为 0.39 μM,基于细胞的试验中 EC50 值为 4.7 μM)。 | |||
T28463 |
PSB-16133 sodium
PSB16133,PSB-16133,PSB 16133 |
P2Y Receptor | GPCR/G Protein; Neuroscience |
PSB-16133 sodium 是一种具有选择性的 P2Y 嘌呤受体变构拮抗剂,其IC值为233 nM。 | |||
T7905 |
PBD-150
|
Beta Amyloid | Neuroscience |
PBD-150 是一种人谷氨酰胺酰基环化酶 Y115E-Y117E 变体的抑制剂,其 Ki=490 nM。 | |||
T40279 |
GLP-1R modulator L7-028
GLP-1R modulator L7-028 |
cAMP; Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator L7-028 是一种变构调节剂,增强了对 GLP-1 的亲和力和 cAMP 信号转导。 | |||
T64221 |
Linvencorvir
RG7907 |
HBV; Antibiotic | Microbiology/Virology |
Linvencorvir 是一种乙型肝炎病毒(HBV)核心蛋白变构调节剂,用于治疗慢性HBV 感染。 | |||
T23649 |
AF-710B
ANAVEX 3-71,AF 710B,AF710B |
Sigma receptor; AChR | GPCR/G Protein; Neuroscience |
AF-710B 是一种特异性变构 M1 毒蕈碱和 Sigma-1 受体激动剂,可用于研究阿尔茨海默病痴呆和神经分裂等神经系统疾病。 | |||
T77407 |
Ensituximab
NPC-1C,NEO-102,NEO-101 |
||
Ensituximab (NEO-102) 是一种准对 MUC5AC 变体的选择性 IgG1 单克隆抗体,具有抗肿瘤活性,抑制结直肠癌和胰腺癌。 | |||
T10851 |
CMP-Sialic acid sodium salt
CMP-Neu5Ac sodium salt |
Endogenous Metabolite | Metabolism |
CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) 是 UDP-GlcNAc 2-epimerase 的变构抑制剂,是唾液酸的活化形式,广泛存在于动物体内,参与生物体的代谢。 | |||
T64387 |
2-Nitrobenzoic acid
o-Nitrobenzoic acid |
Others | Others |
2-Nitrobenzoic acid (o-Nitrobenzoic acid) 是一种抗增殖化合物,对表达 T 型钙通道α1H 或其剪接变体δ25的 jurkat 细胞系显示出8.3μM 的 IC50。 | |||
T24612 |
Pentachloropseudilin
PClP,Antibiotic A 15104 Y |
Myosin; Antibiotic; TGF-beta/Smad | Cytoskeletal Signaling; Microbiology/Virology; Stem Cells |
Pentachloropseudilin (PClP) 是一种可逆的变构 1 型肌球蛋白抑制剂,具有抗菌活性,抑制 Myo1s 和 5 类肌球蛋白。Pentachloropseudilin 抑制生长因子-β (TGF-β) ,可阻断克氏锥虫对宿主细胞的侵袭。 | |||
T4220 |
BQR-695
BQR695,NVP-BQR695 |
PI3K; Parasite; PI4K | Microbiology/Virology; PI3K/Akt/mTOR signaling |
BQR-695 (NVP-BQR695) 是一种磷脂酰肌醇 4-激酶抑制剂,对于人类和疟原虫 PI4KIIIβ 的 IC50值分别为 80 和 3.5 nM。 | |||
T11421 |
Glutaminase-IN-1
CB839 derivative |
transporter | Metabolism |
Glutaminase-IN-1 (CB839 derivative),是一种新型 1,3,4-硒二氮基肾型谷氨酰胺酶(KGA) 的变构抑制剂,在侵袭性 H22 肝癌异种移植模型中显示出抗肿瘤活性。 | |||
T26863 |
BMS-929075
BMS 929075,BMS929075 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
BMS-929075是一种具有口服活性 HCV NS5B 复制酶 (HCV NS5B replicase) 手掌位点变构抑制剂,具有有效性、 较高的口服生物利用度和药代动力学参数 。BMS-929075 显示出细胞毒性。 | |||
T60684 |
FBA-IN-1
|
Antifungal | Microbiology/Virology |
FBA-IN-1 是果糖-1,6-二磷酸醛缩酶(FBA) 共价变构抑制剂,具有抗病毒和抗真菌活性,抑制白色念珠菌,可用于研究真菌感染。 | |||
T61191 |
EAI001
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EAI001 是一种具有有效性和选择性的突变体表皮生长因子受体 (EGFR) 变构抑制剂,对 EGFRL858R/T790M 有抑制作用, IC50 值为 24 nM。EAI001 可用于研究癌症。 | |||
T82236 |
HBED-CC-tris(tert-butyl ester)
|
Others | Others |
HBED-CC-tris(tert-butyl ester)是HBED-CC的一种单价变体,可用于合成基于非对称 HBED-CC 的放射性化合物,可用于肿瘤成像。 | |||
T1952 |
MK-2206 dihydrochloride
MK-2206 2HCl |
Apoptosis; Akt; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
MK-2206 dihydrochloride (MK-2206 2HCl) 是一种变构 Akt 抑制剂,抑制 Akt1、Akt2 和 Akt3 (IC50=8/12/65 nM),具有口服活性的、高效选择性。MK-2206 dihydrochloride 具有抗肿瘤活性。 | |||
T30248 |
AZD 3043
TD 4756,THRX 918661,AZD-3043,AZD3043 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
AZD 3043 (THRX 918661)是 γ-氨基丁酸 A 型受体的变构调节剂,是一种新型镇静催眠剂,是一种潜在的短效麻醉剂,在大鼠中产生催眠和脑电图抑制。AZD 3043可增强γ-氨基丁酸A型受体,抑制神经元烟碱乙酰胆碱受体。 | |||
TP1591L |
OVA G4 peptide acetate(148274-82-2 free base)
SIIGFEKL acetate |
Others | Others |
OVA G4 peptide acetate(148274-82-2 free base) (SIIGFEKL acetate) 是激动剂卵清蛋白 (OVA) 肽 (257-264) SIINFEKL 的变体。 OVA 肽是卵清蛋白的 I 类 (Kb) 限制性肽表位,由 I 类 MHC(主要组织相容性复合物)分子 H-2Kb(小鼠 MHC I 类基因)呈递。 | |||
T60835 |
SKF83959
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
SKF83959 是苯并氮平类化合物,是一种具有选择性和有效性的多巴胺D1受体部分激动剂,对大鼠D1,D5,D2和D3受体的Ki 值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 是 sigma (σ)-1受体的有效变构调节剂,可改善认知功能障碍,用于研究抑郁症和阿尔茨海默病。 | |||
T10534 |
BI-4020
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
BI-4020 是一种第四代,口服有效,非共价的 EGFR 酪氨酸激酶抑制剂。BI-4020 表现出对三联突变的 EGFR del19 T790M C797S 突变体 ( BaF3 细胞系,IC50=0.2 nM),双重突变的 EGFR del19 T790M 以及单突变的 EGFR del19 (IC50=1 nM)的抑制剂活性。BI-4020 保留了抑制 EGFR wt 的活性 (IC50=190 nM)。BI-4020 具有高激酶组选择性和良好的 DMPK 性质。 | |||
T31145 |
CycLuc3
Cyc Luc 3,Cyc-Luc-3 |
Others | Others |
CycLuc3 is a type of mutant firefly luciferase variant with enhanced light emission. | |||
T39093 |
TCTDSTNCYKAT
|
||
TCTDSTNCYKAT is an engineered-variant peptide of antifreeze protein (AFP). | |||
T85152 |
KT109 N2 Regioisomer
|
Others | Others |
KT109 N2 regioisomer, an N2-carbamoylated variant of the diacylglycerol lipase β (DAGLβ) inhibitor KT109, serves as an internal standard for KT109 quantification. | |||
T39017 |
OVA-E1 peptide
OVA-E1 peptide |
||
OVA-E1 peptide, a variant antagonist of SIINFEKL [OVA (257-264)], elicits comparable activation of the p38 and JNK cascades in both mutant and wild-type thymocytes. | |||
T38817 |
Golgicide A-1
GCA-1,Golgicide A-1 |
Others | Others |
Golgicide A-1 (GCA-1) is a moderately potent cis-diastereomer variant of Golgicide A (GCA) specifically designed to inhibit mosquito reproduction. | |||
T84976 |
8(Z)-Eicosenoic Acid methyl ester
cis-8-Eicosenoic Acid methyl ester |
Others | Others |
Methyl 8(Z)-eicosenoate, an esterified variant of 8(Z)-eicosenoic acid, serves as a standard for quantifying 8(Z)-eicosenoic acid utilizing gas chromatography. | |||
T81977 |
Kobusine derivative-1
|
Others | Others |
Kobusine derivative-1,一种Kobusine衍生物,展现出了对癌细胞显著的抗增殖活性。 | |||
T84509 |
Sphingosine (d15:1)
D-erythro-Sphingosine C-15 |
Others | Others |
Sphingosine (d18:1), an amino alcohol, is chiefly recognized for its 18-carbon unsaturated hydrocarbon chain. Nevertheless, in mammalian tissues, both sphingosine and its variant, dihydrosphingosine, feature hydrocarbon chains ranging from 12 to 26 carbons. Sphingosine (d15:1) represents a naturally rare variant, serving as an internal standard for chromatographic or spectrometric analyses of sphingoid compounds. | |||
T40568 |
Fmoc-MMAE
|
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-MMAE, a protective group-conjugated variant of monomethyl auristatin E (MMAE), serves as a powerful inhibitor of tubulin. It finds application in the synthesis of antibody-drug conjugates (ADC). | |||
T39246 |
Brain Natriuretic Peptide-45, mouse
Brain Natriuretic Peptide-45, mouse,BNP-45, mouse |
||
Mouse Brain Natriuretic Peptide-45 (BNP-45, mouse) is a circulating variant of the mouse brain natriuretic peptide derived from the mouse heart. It exhibits powerful hypotensive and natriuretic properties. | |||
T83540 |
(Gly22)-amyloid beta-protein(1-40)
|
||
(Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) 是用于阿尔茨海默病研究的肽。 | |||
T76588 |
(Asp37)-Amyloid β-Protein (1-42)
|
||
(Asp37)-Amyloid β-Protein (1-42) 是野生型 Amyloid-beta (1-42) 肽的 G37D 突变体。 | |||
T83845 |
8-(4-azidophenacylthio) NAD+ sodium
Click Tag™ 8-(4-azidophenacylthio) NAD+,8-(4-azidophenacylthio) Nicotinamide adenine dinucleotide |
||
8-(4-azidophenacylthio) NAD+ 是NAD+信号分子及酶辅因子的一种可点击形式。 | |||
T62672 |
D5261
|
Others | Others |
D5261 是一个有效的、类型 III 变构的 tropomyosin-related kinase A (TrkA) 抑制剂。 | |||
T37966 |
T-91825
|
Others | Others |
T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2]. | |||
T76623 |
(Gln22)-Amyloid β-Protein (1-42)
|
||
'(Gln22)-Amyloid β-Protein (1-42)',为β-Amyloid (1-42) 的Dutch突变(E22Q)形式,显示出提升的纤维原性及致病性。 | |||
T70338 |
Lu AF58786
|
Others | Others |
Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively. | |||
T84939 |
Metformin hydroxy analog 2
N-Carbonylguanidine |
Others | Others |
Metformin hydroxy analog 2, an oxidation product of the biguanide metformin (1), represents a chemically transformed variant of the original compound, showcasing a modified molecular structure through the process of oxidation. | |||
T81069 |
Sulfamidopyrine sodium salt
Melaminsulfone sodium salt |
Others | Others |
Sulfamidopyrine (Melaminsulfone) sodium salt为活性化学物质,适用于分析研究。 | |||
T81150 |
SLSLSPG
|
||
SLSLSPG是通过从人Igγ-1的重链C端分离得到的,为IgG中的一种常见变体。 | |||
T11195 |
Enantiomer of Sofosbuvir
|
Others | Others |
Enantiomer of Sofosbuvir 是Sofosbuvir 的对映异构体,Sofosbuvir 是一种治疗慢性丙型肝炎的处方药,目前尚无enantiomer of Sofosbuvir 的生物活性报道。 | |||
T61329 |
HP1142
|
Others | Others |
HP1142 is a highly effective and specific inhibitor targeting the FLT3 receptor tyrosine kinase, with a particular affinity for its mutant variant FLT3/ITD. It exhibits a benzoimidazole scaffold-based structure, making it a promising compound for investigating and studying the FLT3/ITD mutation in the context of leukemia research [1]. | |||
T38460 |
SN52
|
||
SN52 is a powerful, competitive, and cell-permeable inhibitor of NF-κB2. It is a variant of the SN50 peptide. SN52 effectively prevents the nuclear translocation of p52-RelB heterodimers, exhibiting a robust radiosensitization effect on prostate cancer cells. This compound holds significant potential for cancer research purposes. | |||
T76557 |
Myristoyl-MEK1 Derived Peptide Inhibitor 1
|
||
Myristoyl-MEK1 Derived Peptide Inhibitor 1 是MEK1Derived Peptide Inhibitor 1 的豆蔻酰化形式。Myristoyl-MEK1 Derived Peptide Inhibitor 1 抑制ERK 的激活,IC50为 10 μM。 | |||
T76944 |
Cergutuzumab amunaleukin
|
||
Cergutuzumab amunaleukin (CEA-IL2v) 是一种靶向癌胚抗原 (CEA) 的IL-2变体,作为免疫细胞因子,展现出免疫刺激与抗肿瘤活性。 | |||
T81257 |
Rosuvastatin zinc salt
Rosuvastatin zinc |
Others | Others |
Rosuvastatin zinc salt (Rosuvastatin zinc),为Rosuvastatin的含锌盐形态,属于HMG-CoA还原酶抑制剂类药物,常用于动脉粥样硬化的研究领域。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8083 |
Pyridoxal 5'-phosphate monohydrate
Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛 |
Others | Others |
Pyridoxal 5-phosphate monohydrate 是维生素B6的活性形式,也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中最重要的辅酶变异体,能够与其他变异体(如 PNP 、 PMP)发生互换。 | |||
T4757 |
L-Homoserine
(S)-2-氨基-4-羟基丁酸,(S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID |
Others; Endogenous Metabolite | Metabolism; Others |
L-Homoserine ((S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID) 是天然存在的非蛋白丝氨酸,是合成苏氨酸、蛋氨酸和赖氨酸的共有中间体。它是氨基酸丝氨酸的更具反应性的变体。 | |||
T72643 |
Saccharothrixin F
|
Others | Others |
Saccharothrixin F 是一种高度氧化的糖丝菌,具有抗菌和抗炎活性。 | |||
TN7281 |
Bequinostatin A
|
Others | Others |
Glutathione S-Transferase (GST) π-class inhibitor acts to inhibit a specific class within the GST enzyme family, targeting the π variant. This compound selectively blocks the activity of this enzyme, which plays a critical role in the detoxification of compounds by catalyzing their conjugation with glutathione. | |||
T81797 |
Microcystin-LF
|
||
Microcystin-LF 是 Microcystin-LR 的苯丙氨酸变体,属于细菌代谢物,且对 Caco-2 细胞显示出细胞毒性。 | |||
T81813 |
Methyl lucidenate Q
|
||
Methyl lucidenate Q,一种灵芝甲酯,展现了显著的抑制作用于EBV-EA诱导活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03025 |
VlpE Protein, Mycoplasma hyorhinis, Recombinant (His & Myc)
VlpE prolipoprotein,Variant surface antigen E,vlpE |
Mycoplasma hyorhinis | E. coli |
Responsible for the antigenic diversity for host adaptation. Expression in E.coli of a construct containing vlpD, vlpE, and vlpF yields antigenically distinguishable products corresponding to each gene. | |||
TMPY-04622 |
PF4V1 Protein, Human, Recombinant (mFc)
PF4A,CXCL4V1,platelet factor 4 variant 1,PF4-ALT,SC... |
Human | HEK293 Cells |
PF4V1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34.6 kDa and the accession number is P10720. | |||
TMPJ-00643 |
TIE2 Protein, Human, Recombinant (aa 23-745, His)
VMCM1,TEK,Tie2,hTIE2,p140 TEK,soluble TIE2 variant ... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (aa 23-745, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-120 KDa and the accession number is Q02763-1. | |||
TMPK-01517 |
HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Monomer Protein, Human, MHC (His & Avi)
survivin variant 3 alpha,MHC I,BIRC5,EPR-1,IAP4,Sur... |
Human | HEK293 Cells |
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. | |||
TMPK-01516 |
HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer Protein, Human, MHC (His & Avi)
IAP4,survivin variant 3 alpha,BIRC5,Survivin,EPR-1,... |
Human | HEK293 Cells |
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. | |||
TMPJ-00642 |
TIE2 Protein, Human, Recombinant (hFc)
TEK tyrosine kinase, endothelial,EC 2.7.10,Tie2,hTIE2,p140 T... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1. | |||
TMPK-01480 |
HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
IAP4,Survivin,API4,BIRC5,MHC,MHC I,EPR-1,survivin varian... |
Human | HEK293 Cells |
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. | |||
TMPH-01452 |
Human herpesvirus 6A (HHV-6 variant A) (strain GS) Glycoprotein 105 (His & Myc)
U96/U97/U98/U99/U100,Glycoprotein 105 |
HHV-6A | E. coli |
Human herpesvirus 6A (HHV-6 variant A) (strain GS) Glycoprotein 105 (His & Myc) is expressed in E. coli. | |||
TMPH-01453 |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Glycoprotein U22 (His)
U22,Glycoprotein U22 |
HHV-6A | E. coli |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Glycoprotein U22 (His) is expressed in in vitro E. coli expression system. | |||
TMPH-01458 |
Human herpesvirus 6B (HHV-6 variant B) (strain Z29) Protein U22 (His)
Protein U22,U22 |
HHV-6B | E. coli |
Human herpesvirus 6B (HHV-6 variant B) (strain Z29) Protein U22 (His) is expressed in in vitro E. coli expression system. | |||
TMPJ-00712 |
MPZL1 Protein, Human, Recombinant (His)
FLJ96614,mRNA,Myelin protein zero-like 1,cDNA FLJ78597,cDNA,... |
Human | HEK293 Cells |
Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin... | |||
TMPH-01454 |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Probable ganciclovir kinase (His)
U69,Probable ganciclovir kinase |
HHV-6A | E. coli |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Probable ganciclovir kinase (His) is expressed in E. coli. | |||
TMPJ-01131 |
UBE2V2 Protein, Human, Recombinant (His)
Enterocyte Differentiation-Associated Factor 1,Vitamin D3-In... |
Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains and which leads to protein degradation by the proteasome. UBE2V2 mediates transcriptional activation of target genes. It plays a role in the control of progress through the cell cycle and... | |||
TMPH-01455 |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Triplex capsid protein 1 (His)
Triplex capsid protein 1,TRX1 |
HHV-6A | E. coli |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Triplex capsid protein 1 (His) is expressed in E. coli. | |||
TMPH-01450 |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His)
Phosphoprotein P41,U27,DNA polymerase processivity factor,Po... |
HHV-6A | P. pastoris (Yeast) |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His) is expressed in Yeast. | |||
TMPH-01456 |
Human herpesvirus 6B (HHV-6 variant B) (strain Z29) Glycoprotein Q1 (His & Myc)
Glycoprotein 105,HCLF1 protein,Glycoprotein Q-80k,Glycoprote... |
HHV-6B | E. coli |
Human herpesvirus 6B (HHV-6 variant B) (strain Z29) Glycoprotein Q1 (His & Myc) is expressed in E. coli. | |||
TMPH-01451 |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Envelope glycoprotein B (His & Myc)
gB,Envelope glycoprotein B |
HHV-6A | E. coli |
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Envelope glycoprotein B (His & Myc) is expressed in E. coli. | |||
TMPJ-01100 |
UBE2V1 Protein, Human, Recombinant (His)
TRAF6-Regulated IKK Activator 1 Beta Uev1A,P/OKcl.19,TRAF6-R... |
Human | E. coli |
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Ly... | |||
TMPH-01457 |
Human herpesvirus 6B (HHV-6 variant B) (strain Z29) mRNA export factor ICP27 homolog (His & Myc)
mRNA export factor ICP27 homolog |
HHV-6B | E. coli |
Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs. Human herpesvirus 6B (HHV-6 variant B) (strain Z29) mRNA export factor ICP27 homolog (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.6 kDa and the accession number is P52539. | |||
TMPY-04826 |
LILRB5/CD85c Protein, Human, Recombinant (His)
leukocyte immunoglobulin like receptor B5,LIR8,LIR-8,CD85C |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weig... | |||
TMPY-02580 |
Histone H1 Protein, Human, Recombinant (His)
HSP60,HSP65,CPN60,H1 histone family, member 0,H10,HLD4,HSPD1... |
Human | E. coli |
H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "beads on a string" sub-structure into a high order structure. The lysine-rich H1 histone family in mammals includes eleven members. In higher eukaryotes, all H1 variants have the same general structure, consisting of a central conserved globular domain and less conserved N-termin... | |||
TMPY-02030 |
CD82 Protein, Human, Recombinant (His)
CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1... |
Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud... | |||
TMPK-01362 |
SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated
MYD1,SIRP α V4,PTPNS1,BIT,SHPS1,SIRP alpha,SHPS-1,SIRP α,MFR... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... | |||
TMPK-01363 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD172a,SIRP α... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... | |||
TMPK-01356 |
SIRP alpha V4 Protein, Human, Recombinant (His & Avi)
BIT,SIRP α V4,MFR,SHPS1,SIRPA,SIRP α,P84,MYD1,MYD-1,PTPNS1,S... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi... | |||
TMPK-01364 |
SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated
SIRP α,MFR,SHPS1,SIRPA,BIT,SHPS-1,MYD-1,SIRP alpha,P84,CD172... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... | |||
TMPK-01358 |
SIRP alpha V6 Protein, Human, Recombinant (His & Avi)
P84,SIRPA,SIRP alpha,SHPS-1,MFR,BIT,MYD1,SIRP α V6,SHPS1,SIR... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi... | |||
TMPY-02682 |
NELL2 Protein, Human, Recombinant (His)
NEL-like 2 (chicken),NRP2 |
Human | Baculovirus Insect Cells |
A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in the mammal. NELL2 is an abundant glycoprotein containing an EGF-like domain in the neural tissues where it has multiple physiological functions by interacting with protein kinase C (PKC). There are two different splicing variant forms of NELL2 identified so far. One is secreted NELL2 (sNELL2) which is a neuron-specific variant and the other is cytos... | |||
TMPY-06273 |
LILRB5/CD85c Protein, Human, Recombinant (hFc)
LIR-8,LIR8,CD85C,leukocyte immunoglobulin like receptor B5 |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weig... | |||
TMPY-05186 |
LILRB5/CD85c Protein, Human, Recombinant (His), Biotinylated
LIR-8,LIR8,leukocyte immunoglobulin like receptor B5,CD85C |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted ... | |||
TMPJ-01244 |
FAM172A Protein, Human, Recombinant (His)
Protein FAM172A,C5orf21 |
Human | HEK293 Cells |
FAM172A is encoded by FAM172A gene. It is a 416 aa. protein, and belongs to the UPF0528 family. This protein has 4 isoforms produced by alternative splicing. There is a natural variant location which is S131N. FAM172A has a 18 aa. signal peptide which helps it to be secreted protein. | |||
TMPK-01487 |
HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Monomer Protein, Human, MHC (His & Avi)
svn-2B,Survivin-2B,svn 2B |
Human | HEK293 Cells |
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus. | |||
TMPK-01481 |
HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
svn 2B,svn-2B,Survivin-2B |
Human | HEK293 Cells |
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus. | |||
TMPK-01486 |
HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Tetramer Protein, Human, MHC (His & Avi)
svn-2B,Survivin-2B,svn 2B |
Human | HEK293 Cells |
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus. | |||
TMPK-01146 |
LGMN Protein, Human, Recombinant (His)
AI746452,Legumain,LGMN1,Prsc1,AEP,LGMN,AU022324 |
Human | HEK293 Cells |
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD. | |||
TMPJ-01238 |
VSTM2A Protein, Human, Recombinant (His)
VSTM2,V-set and transmembrane domain-containing protein 2A |
Human | HEK293 Cells |
VSTM2A, also called VSTM2, is short for V-set and transmembrane domain-containing protein 2A. It is a 236 aa. protein which can be departed into two parts. The first 24 aa. is a signal peptide, and the last is a V-set and transmembrane domain-containing protein 2A. There is a natural variant location which is E84K. | |||
TMPK-00435 |
SARS-COV-2 Spike S Trimer Protein (D614G, His & Avi)
S protein,Spike glycoprotein,COVID-19,S glycoprotein |
SARS-CoV-2 | HEK293 Cells |
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a matter of months. Recently, that D614G was been found more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin. | |||
TMPK-00012 |
CXCL4 Protein, Human, Recombinant (His & Avi)
PF-4,CXCL4,SCYB4,Oncostatin-A,MGC138298,Iroplact |
Human | E. coli |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (His & Avi) is expresse... | |||
TMPK-01248 |
CXCL4 Protein, Mouse, Recombinant (hFc)
PF-4,CXCL4,SCYB4,Oncostatin-A,Iroplact,MGC138298 |
Mouse | HEK293 Cells |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Mouse, Recombinant (hFc) is expressed in H... | |||
TMPK-00014 |
CXCL4 Protein, Human, Recombinant (hFc)
Iroplact,CXCL4,Oncostatin-A,PF-4,MGC138298,SCYB4 |
Human | HEK293 Cells |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (hFc) is expressed in H... | |||
TMPK-00013 |
CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylated
SCYB4,MGC138298,PF-4,Iroplact,Oncostatin-A,CXCL4 |
Human | E. coli |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylat... | |||
TMPY-04510 |
PSAP/Prosaposin Protein, Human, Recombinant (His)
prosaposin,SAP1,GLBA |
Human | HEK293 Cells |
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro... | |||
TMPY-00209 |
PSAP/Prosaposin Protein, Rat, Recombinant (His)
prosaposin |
Rat | HEK293 Cells |
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro... | |||
TMPY-02298 |
ACYP2 Protein, Human, Recombinant (GST)
ACYM,acylphosphatase 2, muscle type,ACYP |
Human | E. coli |
Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We sought to explore the role of these genetic susceptibility factors to cisplatin-induced ototoxicity in patients with testicular cancer. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 a... | |||
TMPJ-00499 |
GSTP1 Protein, Human, Recombinant
GSTP1,GST3,GST class-pi,Glutathione S-transferase P,FAEES3,G... |
Human | E. coli |
Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione ... | |||
TMPJ-00012 |
CXCL4 Protein, Human, Recombinant (His)
SCYB4,PF4,Iroplact,Platelet Factor 4,PF-4,Oncostatin-A,CXCL4... |
Human | HEK293 Cells |
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokin... | |||
TMPY-03985 |
Adenosine Deaminase Protein, Human, Recombinant (His)
ADA1,adenosine deaminase,ADA |
Human | Baculovirus Insect Cells |
Adenosine Desaminase (ADA) deficiency, is a purine metabolic disorder that cause severe combined immunodeficiency (SCID) due to the accumulation of toxic metabolites that primarily affects development, differentiation and function of T and B lymphocytes. Adenosine deaminase is a polymorphic enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor activity. ADA activity might be considered as... | |||
TMPY-02120 |
XPNPEP2 Protein, Human, Recombinant (His)
AEACEI,X-prolyl aminopeptidase (aminopeptidase P) 2, membran... |
Human | HEK293 Cells |
Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution ... | |||
TMPY-02765 |
GM2A Protein, Human, Recombinant (His)
GM2 ganglioside activator,SAP-3,GM2-AP |
Human | Baculovirus Insect Cells |
GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexo... | |||
TMPY-02051 |
FABP2 Protein, Human, Recombinant (His)
MGC133132,fatty acid binding protein 2,FABPI,I-FABP |
Human | E. coli |
Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids. FABP family proteins could be used as tissue specific injury marker based on the following characteristics of FABP. The intestinal fatty acid binding protein (I-FABP), or fatty acid-binding protein 2 (FABP2), an intracellular protein expressed only in the intestine, involved in the a... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T19185 |
Aldosterone-d8
醛固酮 D8,Aldosterone D8 |
Others | Others |
Aldosterone D8, a deuterium-labeled variant of Aldosterone produced in the adrenal zona glomerulosa, regulates blood pressure. | |||
T12523 |
Posaconazole-D5
SCH 56592-D5 |
Others | Others |
Posaconazole-D5, a deuterium-labeled variant of Posaconazole, is a second-generation, broad-spectrum triazole compound with antifungal activity. | |||
T11675 |
Irbesartan-d4
厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4 |
Others | Others |
Irbesartan D4, a deuterium-labeled variant of Irbesartan, is a highly potent and specific antagonist of the angiotensin II type 1 (AT1) receptor. | |||
T11867 |
Loperamide-d6 hydrochloride
R-18553 D6 hydrochloride |
Others | Others |
Loperamide D6 hydrochloride, a deuterium-labeled variant of Loperamide hydrochloride, acts as an opioid receptor agonist utilized for diarrhea treatment. | |||
T12522 |
Posaconazole-D4
SCH 56592-D4 |
Others | Others |
Posaconazole-D4, a deuterium-labeled variant of Posaconazole, is a broad-spectrum, second-generation triazole with antifungal activity. | |||
T11250 |
Ezetimibe-d4
SCH 58235 D4 |
Others | Others |
Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation of Nrf2. | |||
T11152 |
Edaravone-d5
MCI-186 D5 |
Others | Others |
Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the original compound's attributes while offering isotopic labeling benefits. | |||
T39423 |
Palmitic acid-13C sodium
|
||
Sodium palmitate-13C is the 13C-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animals and plants. This compound has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in mouse granulosa cells. | |||
T39441 |
L-Arginine-15N4 hydrochloride
L-Arginine-15N4 hydrochloride,(S)-(+)-Arginine-15N4 hydrochloride |
||
L-Arginine-15N4 ((S)-(+)-Arginine-15N4) hydrochloride, the 15N-labeled variant of L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride), serves as the nitrogen donor in the synthesis of nitric oxide. This potent vasodilator is crucial, especially during a sickle cell crisis where its levels are notably diminished. | |||
T73716 |
Miglustat-d9 HCl
|
||
Miglustat-d9 (hydrochloride)为Miglustat (hydrochloride)的氘代物,属于葡萄糖神经酰胺合成酶抑制剂,主要用于治疗I型戈谢病。 | |||
T11240 |
Ethacrynic acid D5
|
Others | Others |
Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by... | |||
T77211 |
Sudan I-d5
|
||
Sudan I-d5为Sudan I的一种氘代物。作为一种偶氮共轭红色染料(red dye),Sudan I常被作为油、溶剂或抛光剂的添加剂使用。此外,Sudan I能够抑制产气荚膜梭菌及鼠李糖菌的生长。 | |||
T73820 |
Bosentan-d4
|
||
Bosentan-d4 是 Bosentan 的氘代物。Bosentan 是一种有效的endothelin-1 (ET)拮抗剂,在人的 SMC 细胞中,作用于ETA 和ETB 受体,Ki 值分别为 4.7 nM 和 95 nM。 | |||
T70313 |
Indoxyl Sulfate-d5 potassium salt
|
||
Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ... |