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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T34862 |
Thromboxane A2
Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2 |
Others | Others |
Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction. | |||
T36548 |
Carbocyclic Thromboxane A2
|
Others | Others |
Carbocyclic Thromboxane A2 可用于生命科学领域的相关研究。其产品编号为 T36548,CAS号为 74034-56-3。 | |||
T36208 |
15(R)-Pinane Thromboxane A2
15(R)-Pinane Thromboxane A2 |
Others | Others |
15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle. | |||
T6236 |
Ozagrel
奥扎格雷,OKY-046,Domenan |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂,可抑制哮喘。它也是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
T6625 |
Ozagrel hydrochloride
Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel hydrochloride (OKY-046 HCl) 是一种选择性血栓素 A(2) 合成酶抑制剂,用于改善术后脑血管收缩和伴随的脑缺血。它是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
T11339 |
Furegrelate sodium
U-63557A |
PPAR | DNA Damage/DNA Repair; Metabolism |
Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂,抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。 | |||
T17039 |
Terbogrel
BIBV 308SE |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Terbogrel 是一种可口服的 、具有选择性 thromboxane A2 受体拮抗剂(IC50 约为 10 nM),是一种 thromboxane A2 synthase 抑制剂(IC50 约为 10 nM)。Terbogrel 是一种抗血小板化合物,可抑制血小板聚集,是预防血栓的潜在化合物。 | |||
T12268 |
NTP42
|
Prostaglandin Receptor; PPAR | DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism |
NTP42 是血栓素 A2 (TXA2) 受体的拮抗剂,IC50为 3.278 nM,可用于肺动脉高压的相关研究。 | |||
T11339L |
Furegrelate
|
PPAR | DNA Damage/DNA Repair; Metabolism |
FUREGRELATE 是一种血栓素 A2 (TxA2) 合酶抑制剂,可减缓新生仔猪肺动脉高压的发展。 | |||
T31213 |
Dazmegrel
UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Dazmegrel (UK 38,485) 是一种强效特异性血栓素 A2(TXA2)合成酶抑制剂,可用于预防正常妊娠中全血小板聚集增加。 | |||
T68022L |
Sulotroban potassium
BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base) |
PPAR | DNA Damage/DNA Repair; Metabolism |
Sulotroban potassium 是一种小分子血栓素A2受体(TXA2R)拮抗剂,可用于研究心肌梗塞和血栓形成。 | |||
T27630 |
Isbogrel
CV4151,CV-4151,CV 4151 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Isbogrel (CV4151)是一种小分子血栓素A2合成酶(TXA2 synthase)抑制剂,可用来研究心律失常、短暂性脑缺血发作和血栓形成。 | |||
T15049 |
Daltroban
BM-13505,SKF 96148 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Daltroban (SKF 96148) (BM-13505) 是选择性和特异性的血栓素 A2 (TXA2) 受体拮抗剂。Daltroban 可以增加血管平滑肌细胞内钙。Daltroban 显示对再灌注损伤的保护作用。 | |||
T15577 |
Indobufen
Ibustrin,吲哚布芬 |
COX | Immunology/Inflammation; Neuroscience |
Indobufen (Ibustrin) 是一种血小板聚集抑制剂,是下调单核细胞中的组织因子,可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。 | |||
T0212 |
Seratrodast
塞曲司特,AA 2414,ABT-001 |
COX; Prostaglandin Receptor; PPAR | DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Seratrodast (ABT-001) 是一种血栓素 A2 受体 (TP) 拮抗剂,用于治疗哮喘。 | |||
T68086 |
Imitrodast
|
Thrombin | Proteases/Proteasome |
Imitrodast是一种小分子血栓素A2合成酶(TXA2 synthase)抑制剂,可用于治疗免疫系统疾病、呼吸系统疾病和心血管疾病,可用于研究动脉血栓形成、哮喘和冠状血管痉挛。 | |||
TQ0145 |
(R)-(+)-Bay-K-8644
(R)-(+)-Bay K 8644 |
Calcium Channel; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
(R)-(+)-Bay-K-8644 是一种 Ca2+ 通道抑制剂,也能抑制 Ba2+电流 (IBa),诱导猫的中枢性呼吸抑制,通过竞争性拮抗血栓素 A2-前列腺素 H2 受体抑制血小板活化。 | |||
T0839 |
Ketoprofen
酮基布洛芬,RP-19583,酮洛芬 |
Apoptosis; COX; MRP | Apoptosis; Immunology/Inflammation; Neuroscience |
Ketoprofen (RP-19583) 是一种非甾体抗炎剂,能够有效地抑制COX 的活性,在人血单核细胞中,对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。 | |||
T1002 |
Etodolac
Ultradol,AY-24236,依托度酸,Etodolic acid,Lodine |
Retinoid Receptor; COX | Immunology/Inflammation; Metabolism; Neuroscience |
Etodolac (AY-24236) 是一种吡喃羧酸和非甾体抗炎药,具有解热和镇痛活性,对 COX 的 IC50为53.5 nM。 | |||
T22896 |
L-655,240
|
Others | Others |
L-655,240 is a thromboxane A2/prostaglandin endoperoxide receptor antagonist. | |||
T23670 |
AH 22921
AH22921,AH-22921 |
Others | Others |
AH 22921 is an antagonist of thromboxane A2. | |||
T68199 |
Nafagrel
|
Others | Others |
Nafagrel is a thromboxane A2 synthetase inhibitor. | |||
T70541 |
IS-145
|
Others | Others |
IS-145 is a thromboxane A2 receptor antagonist. | |||
T70966 |
GR-36246
|
Others | Others |
GR-36246 is a Thromboxane A2-receptor blocker. | |||
T70871 |
Mipitroban
|
Others | Others |
Mipitroban is a thromboxane A2/prostaglandin H2 antagonist. | |||
T68287 |
Indobufen sodium
|
Others | Others |
Indobufen sodium is a Thromboxane A2 antagonist and Cyclooxygenase inhibitor. | |||
T15252 |
Etersalate
Etherylate,Eterylate |
Others | Others |
Etersalate inhibits platelet function. It also reduces thromboxane A2 (TXA2) levels. | |||
T70561 |
FCE-24265
|
Others | Others |
FCE-24265 is a calcium & thromboxane A2 synthase inhibitor. | |||
T70737 |
HN 11500
|
Others | Others |
HN 11500 is an antithrombotic agent and thromboxane A2 receptor antagonist. | |||
T29722 |
AGN 191976
|
Others | Others |
AGN 191976 is a novel thromboxane A2-mimetic. | |||
T28176 |
Nizofenone
Y9179,Y-9179,Ekonal,Y 9179 |
Others | Others |
Nizofenone, a thromboxane A2 (TXA2) biosynthesis inhibitor, is used as a neuroprotective drug and used to treat stroke. | |||
TP2356 |
Triletide
Triletida,Triletidum |
||
Triletide is a thromboxane A2 antagonist agent. | |||
T68627 |
Ono 11119
|
Others | Others |
Ono 11119 is a thromboxane A2 antagonist. | |||
T28841 |
SQ 26655
SQ26655,SQ-26655 |
Others | Others |
SQ 26655 is an antagonist of thromboxane A2/prostaglandin H2. | |||
T27575 |
ICI 192605
ICI192605,ICI-192605 |
Others | Others |
ICI 192605 is a potent thromboxane A2 receptor (TP receptor) antagonist. | |||
T70739 |
KW 4099
|
Others | Others |
KW 4099 is a thromboxane A2 antagonist. | |||
T68198 |
Nafagrel hydrochloride
|
Others | Others |
Nafagrel hydrochloride is a thromboxane A2 synthetase inhibitor. | |||
T71233 |
HN-11501
|
Others | Others |
HN-11501 is a Thromboxane A2 receptor antagonist. | |||
T28242 |
Ono 3708
Ono-3708,Ono3708 |
Others | Others |
Ono-3708 is a potent antagonist of the thromboxane A2/prostaglandin endoperoxide receptor in vitro and in vivo. | |||
T71405 |
Domitroban
|
Others | Others |
Domitroban, also known as S-145, is a thromboxane (Tx) A2-receptor antagonist with partial agonistic activity in vascular smooth muscle. | |||
T22897 |
L-670,596
|
Others | Others |
L-670,596 is a thromboxane A2/prostaglandin endoperoxide receptor antagonist. | |||
T24310 |
L 657925
L-657925,L657925 |
Others | Others |
L 657925 is an antagonist of the thromboxane A2 receptor. | |||
T71178 |
Nafagrel hydrochloride hemihydrate
|
Others | Others |
Nafagrel hydrochloride hemihydrate is a thromboxane A2 synthetase inhibitor. | |||
T6236L |
Ozagrel Sodium
KCT 0809,KCT-0809,Xanbo,KCT0809,Cataclot,奥扎格雷钠 |
Others | Others |
Ozagrel Sodium is a thromboxane A2 synthase inhibitor. It is used to treat cerebrovascular diseases. | |||
T17189 |
U-46619
9,11-Methanoepoxy PGH2 |
Progesterone Receptor; PPAR | DNA Damage/DNA Repair; Metabolism; Others |
U-46619是一种有效的TXA2激动剂,是一种血栓素A2类似物(内过氧化物),有诱导肌球蛋白轻链9 (Myl9)基因缺失小鼠主动脉平滑肌(SM)收缩的功能。 | |||
T70694 |
HA-29
|
Others | Others |
HA-29 is an inhibitor of thromboxane A2 and prostaglandin endoperoxide receptors. | |||
T70709 |
FCE-27262
|
Others | Others |
FCE-27262 is a prostaglandin H2/thromboxane A2 receptor antagonist. | |||
T29200 |
Z-335 sodium
Z 335,Z335,Z-335 |
Others | Others |
Z-335 Salt, a thromboxane A2 receptor antagonist, is used potentially for the treatment of arterial occlusive disease. | |||
T11764 |
KP496
|
Others | Others |
KP496 is a selective, dual antagonist for Thromboxane A2 receptor and Leukotriene D4 receptor. | |||
T71322 |
CV 6504
|
Others | Others |
CV 6504 is a dual inhibitor of thromboxane A2 synthetase and 5-lipoxygenase. It also possesses oxygen scavenging activity. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36831 |
9-Oxononanoic Acid
9-ONA |
Phospholipase; CPT | Metabolism |
9-Oxononanoic Acid是一种氧化脂肪酸,由亚油酸自氧化形成,它能提高磷脂酶 A2(PLA2)的活性,并增加离体人体血浆中血栓素 B2 的生成。9-Oxononanoic Acid 能减少肝脏新脂肪酸的合成,并提高大鼠肝脏肉碱棕榈酰转移酶(β-氧化的标志物)的活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0281 |
Indobufen-d5
|
||
Indobufen-d5 是 Indobufen 的氘代化合物。Indobufen 的 CAS 号为 63610-08-2。Indobufen 是一种血小板聚集抑制剂,是下调单核细胞中的组织因子,可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。 |