10
1
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8383 |
Cyclopentolate Hydrochloride
|
AChR | Neuroscience |
Cyclopentolate Hydrochloride 是一种阿托品样毒蕈碱受体拮抗剂,是眼科常用的抗毒蕈碱剂,对睫状肌毒蕈碱受体的 pKB 值为 7.8。 | |||
T38776 |
LP-922056
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
LP-922056 是 Notum Pectinacetylesterase 的抑制剂,对人和小鼠的 EC50 值分别为 21 nM 和 55 nM。 | |||
TP2490 |
Palmitoyl Hexapeptide-12 Acetate
Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base) |
Others | Others |
Palmitoyl Hexapeptide-12 Acetate (Palmitoyl Hexapeptide-12 Acetate (171263-26-6 Free base)) 可以促进胶原蛋白、弹性蛋白和透明质酸的增殖。可用于改善皮肤含水量,增加真皮层厚度,减少细纹。 | |||
TP2497 |
Myristoyl Tetrapeptide-12 Acetate
醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base) |
Others | Others |
Myristoyl Tetrapeptide-12 Acetate (Myristoyl Tetrapeptide-12 Acetate (959610-24-3 Free base)) 是肉豆蔻酸和 Tetrapeptide-12 的反应产物,是一种刺激头发和睫毛生长并增强睫毛和/或眉毛外观的肽。 Myristoyl tetrapeptide-12 可以增加角质形成细胞的增殖,改善外观、紧致弹性和皮肤厚度。 | |||
T40908 |
KLD-12
|
||
KLD-12, a 12-residue self-assembling peptide, displays properties that promote chondrogenic differentiation of bone marrow stromal cells (BMSCs). Moreover, KLD-12 hydrogel can effectively fill full-thickness osteochondral defects in their original location, leading to improved cartilage repair. | |||
T37983 |
GM 1489
|
Others | Others |
GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phor... | |||
T76895 | Abicipar pegol | ||
Abicipar pegol (AGN-150998, MP0112) 是一种抗VEGFDARPin 分子,DARPin 分子是一类新型的小蛋白,含有工程化的 ankyrin 重复结构域,以高特异性和亲和力与靶蛋白结合。Abicipar pegol 可有效抑制血管生成和血管通透性,通过玻璃体内注射,降低平均视网膜厚度和渗漏面积,用于眼部炎症等相关疾病研究。 | |||
T68182 |
3-Hydroxykynurenamine
|
Others | Others |
3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ... | |||
T83744 |
Tiger17 TFA
H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2 |
||
Tiger17是一种环状肽,属于tigerinin-RC1和tigerinin-RC2的衍生物,这两种化合物是在螃蟹吃蛙(F. cancrivora)皮肤分泌物中发现的抗微生物肽。在5至20µg/ml的浓度范围内使用时,Tiger17能增加HaCaT角质形成细胞和人类皮肤成纤维细胞的增殖,并且在20µg/ml的浓度下增加HaCaT细胞的迁移。此外,Tiger17还能增加RAW 264.7巨噬细胞的招募及其TGF-β1和IL-6的分泌。在全层皮肤创伤的小鼠模型中,局部应用20µg/ml的Tiger17能加速伤口闭合和重新上皮化的速度。 | |||
T83721 |
Hexafluoropropylene Oxide Dimer Acid
FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA |
Others | Others |
Hexafluoropropylene oxide dimer acid (HFPO-DA)作为一种全氟烷基醚羧酸(PFECA),于HepG2细胞中以250 µM的浓度使用时,可诱导凋亡并增加活性氧种类(ROS)的水平。HFPO-DA以每个蛋4 mg/kg的剂量,会减少孵化鸡右心室壁厚度,增加心率,并诱导肝脏脂肪积累,这些效应可通过敲除过氧化物酶体增殖物激活受体α(Ppara)基因编码实现预防。它减少了斑马鱼胚胎的存活百分比(LC50 = 7,651 mg/L)。在孕妇大鼠给药下,HFPO-DA(250 mg/kg)降低了新生大鼠的平均出生体重、存活时间和血清葡萄糖水平,并增加了血清胆固醇和甘油三酯水平。它已经被发现污染海水和河水。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0875 |
Acetylcysteine
N-Acetylcysteine,乙酰半胱氨酸,N-Acetyl-L-cysteine,LNAC,NAC,N-Acetyl Cysteine,易咳净 |
Apoptosis; TNF; Ferroptosis; Influenza Virus; Reactive Oxygen Species; ROS; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Acetylcysteine (NAC) 是半胱氨酸的 N-乙酰衍生物,是一种 ROS 抑制剂和粘液溶解剂。Acetylcysteine 可诱导细胞凋亡,可用于减少粘液的厚度,还具有抗流感病毒活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T69600 |
Spermidine-d6
|
||
Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki... |