|
TMPH-00304
|
SV2A Protein, Bovine, Recombinant (His & Myc)
Synaptic vesicle glycoprotein 2A,p87,SV2A
|
Bovine
|
HEK293 Cells
|
|
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. SV2A Protein, Bovine, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 22.8 kDa and the accession number is Q29397. |
|
TMPH-03380
|
Synaptophysin/SYP Protein, Rat, Recombinant (His)
Major synaptic vesicle protein p38,Synaptophysin,Sy...
|
Rat
|
E. coli
|
|
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin/SYP Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 34.8 kDa and the accession number is P07825. |
|
TMPH-01997
|
SYNGAP1 Protein, Human, Recombinant (His)
SYNGAP1,Neuronal RasGAP,Synaptic Ras GTPase-activat...
|
Human
|
E. coli
|
|
SYNGAP1 Protein, Human, Recombinant (His) is expressed in E. coli. |
|
TMPJ-00281
|
CADM1 Protein, Mouse, Recombinant (hFc)
IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil...
|
Mouse
|
HEK293 Cells
|
|
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in... |
|
TMPY-05510
|
BDNF Protein, Mouse, Recombinant (His)
brain-derived neurotrophic factor
|
Mouse
|
HEK293 Cells
|
|
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,... |
|
TMPJ-00135
|
BDNF Protein, Human/Murine/Rat, Recombinant
BDNF,Abrineurin,Brain-Derived Neurotrophic Factor
|
Human,Mouse,Rat
|
E. coli
|
|
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ... |
|
TMPY-02245
|
SNAP-25 Protein, Human, Recombinant (His)
synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ106...
|
Human
|
E. coli
|
|
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp... |
|
TMPH-02808
|
NPTX1 Protein, Mouse, Recombinant (His)
Nptx1,Neuronal pentraxin-1,Neuronal pentraxin I
|
Mouse
|
E. coli
|
|
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. |
|
TMPH-02807
|
NPTXR Protein, Mouse, Recombinant (His & Myc)
Neuronal pentraxin receptor,Nptxr
|
Mouse
|
Baculovirus Insect Cells
|
|
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. |
|
TMPH-03379
|
Synaptogyrin-1/SYNGR1 Protein, Rat, Recombinant (His)
p29,Synaptogyrin-1,Syngr1
|
Rat
|
E. coli
|
|
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation. Involved in the regulation of short-term and long-term synaptic plasticity. Synaptogyrin-1/SYNGR1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 31.7 kDa and the accession number is Q62876. |
|
TMPH-02165
|
STXBP1 Protein, Human, Recombinant (His)
MUNC18-1,Syntaxin-binding protein 1,N-Sec1,STXBP1,p67,Protei...
|
Human
|
HEK293 Cells
|
|
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. |
|
TMPH-00929
|
APBA2 Protein, Human, Recombinant (His & Myc)
Adapter protein X11beta,MINT2,Neuronal Munc18-1-interacting ...
|
Human
|
HEK293 Cells
|
|
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. APBA2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 87.5 kDa and the accession number is Q99767. |
|
TMPH-03399
|
VAMP2 Protein, Rat, Recombinant (His)
Vesicle-associated membrane protein 2,Vamp2,Synaptobrevin-2
|
Rat
|
E. coli
|
|
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. VAMP2 Protein, Rat, Recombina... |
|
TMPH-02166
|
STXBP1 Protein, Human, Recombinant
p67,Protein unc-18 homolog A,Protein unc-18 homolog 1,STXBP1...
|
Human
|
E. coli
|
|
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. |
|
TMPK-01233
|
LAMP5 Protein, Human, Recombinant (hFc)
BADLAMP,C20orf103,LAMP-5,dJ1119D9.3,UNC-43,BAD-LAMP
|
Human
|
HEK293 Cells
|
|
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Human, Recombinant (hFc) is expressed in HEK293 ma... |
|
TMPH-03381
|
Synaptoporin/SYNPR Protein, Rat, Recombinant (His)
Synaptoporin,Synpr
|
Rat
|
E. coli
|
|
Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein. Synaptoporin/SYNPR Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 35.2 kDa and the accession number is P22831. |
|
TMPK-00659
|
LAMP5 Protein, Cynomolgus, Recombinant (His)
C20orf103,BAD-LAMP,BADLAMP,LAMP-5,UNC-43,dJ1119D9.3
|
Cynomolgus
|
HEK293 Cells
|
|
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK2... |
|
TMPH-03234
|
Acetylcholinesterase Protein, Rat, Recombinant (His)
AChE,EC:3.1.1.7
|
Rat
|
E. coli
|
|
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Acetylcholinesterase Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 68.9 kDa and the accession number is P37136. |
|
TMPH-03146
|
LAMP5 Protein, Pongo abelii, Recombinant (His & Myc)
Lysosome-associated membrane glycoprotein 5,LAMP5,Brain and ...
|
Pongo abelii
|
E. coli
|
|
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.4 kDa and the accession number is Q5R5V2. |
|
TMPY-01820
|
Munc18-1/STXBP1 Protein, Human, Recombinant (His & GST)
MUNC18-1,RBSEC1,P67,syntaxin binding protein 1,UNC18,NSEC1
|
Human
|
Baculovirus Insect Cells
|
|
Syntaxin-binding protein 1, also known as N-Sec1, Protein unc-18 homolog 1, MUNC18-1 and STXBP1, is a peripheral membrane protein that belongs to the STXBP / unc-18 / SEC1 family. STXBP1 is an evolutionally conserved neuronal Sec1/Munc-18 (SM) protein that is essential in synaptic vesicle release in several species. It may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. STXBP1 is essential for neurotransmission and bin... |
|
TMPH-02161
|
Synapsin-1 Protein, Human, Recombinant (GST)
SYN1,Brain protein 4.1,Synapsin I,Synapsin-1
|
Human
|
E. coli
|
|
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. |
|
TMPJ-01130
|
NPTX1 Protein, Human, Recombinant (His)
Neuronal pentraxin-1,NPTX1,NP1
|
Human
|
HEK293 Cells
|
|
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) at excitatory synapses. Mature human NPTX1 shares 97% aa sequence identity with mouse, and rat NPTX1. It is produced by hippocampal, cerebral and cerebellar neurons, retinal ganglia and the inner nuclear layer of the retina. It is enriched on presynaptic axonal membranes where it ... |
|
TMPH-02278
|
PTPN5 Protein, Human, Recombinant (His & SUMO)
PTPN5,Neural-specific protein-tyrosine phosphatase,Tyrosine-...
|
Human
|
E. coli
|
|
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P54829. |
|
TMPY-02025
|
CPLX2 Protein, Human, Recombinant (His)
CPX-2,Hfb1,921-L,complexin 2,CPX2
|
Human
|
E. coli
|
|
Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target ... |
|
TMPH-03741
|
BoNT/F Protein, Clostridium botulinum, Recombinant (His)
Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin type F
|
Clostridium botulinum
|
E. coli
|
|
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ... |
|
TMPK-00612
|
CSPG5 Protein, Mouse, Recombinant (His)
MGC44034,Chondroitin sulfate proteoglycan 5,Neuroglycan C,Ca...
|
Mouse
|
HEK293 Cells
|
|
CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation. An involvement of CALEB in the presynaptic differentiation of cerebellar GABAergic synapses and revealed a new role for CALEB in synapse elimination in Purkinje cells. |
|
TMPH-01609
|
LGI1 Protein, Human, Recombinant (His & Myc)
Leucine-rich glioma-inactivated protein 1,Epitempin-1,LGI1
|
Human
|
E. coli
|
|
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. |
|
TMPH-03280
|
Dystrophin Protein, Rat, Recombinant (His)
Dystrophin,Dmd
|
Rat
|
P. pastoris (Yeast)
|
|
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. Dystrophin Protein, Rat, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted... |
|
TMPH-01231
|
DIP2A Protein, Human, Recombinant (His)
DIP2A,DIP2,Disco-interacting protein 2 homolog A,C21orf106,D...
|
Human
|
Baculovirus Insect Cells
|
|
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes. |
|
TMPH-03383
|
Synaptotagmin-12 Protein, Rat, Recombinant (His)
Syt12,Synaptotagmin-12,Synaptotagmin XII,Synaptotagmin-relat...
|
Rat
|
E. coli
|
|
Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus. Synaptotagmin-12 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 50.7 kDa and the accession number is P97610. |
|
TMPJ-00652
|
PSD-95 Protein, Rat, Recombinant (His)
PSD95,SAP90,Disks large homolog 4,SAP-90,PSD-95,Postsyna...
|
Rat
|
E. coli
|
|
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the be... |
|
TMPH-01230
|
DIP2A Protein, Human, Recombinant (hFc)
DIP2 homolog A,Disco-interacting protein 2 homolog A,KIAA018...
|
Human
|
HEK293 Cells
|
|
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes. |
|
TMPH-01663
|
GRM5 Protein, Human, Recombinant (His & Myc)
Metabotropic glutamate receptor 5,GRM5
|
Human
|
E. coli
|
|
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. |
|
TMPY-01842
|
Neuroligin-3/NLGN3 Protein, Human, Recombinant (His)
neuroligin 3,HNL3
|
Human
|
HEK293 Cells
|
|
Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NL... |
|
TMPH-01272
|
TRIM9 Protein, Human, Recombinant (His & SUMO)
RING finger protein 91,RING-type E3 ubiquitin transferase TR...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. |
|
TMPY-01692
|
NETO1 Protein, Human, Recombinant (His)
neuropilin (NRP) and tolloid (TLL)-like 1,BCTL1,BTCL1
|
Human
|
HEK293 Cells
|
|
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus repr... |
|
TMPH-02637
|
Embigin Protein, Mouse, Recombinant (His)
Emb,Gp70,Teratocarcinoma glycoprotein Gp-70,Embigin
|
Mouse
|
E. coli
|
|
Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane. Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. Embig... |
|
TMPH-01036
|
Caprin-1/CAPRIN1 Protein, Human, Recombinant (His)
GPI-anchored membrane protein 1,CAPRIN1,GPIP137,M11S1,GPI-an...
|
Human
|
Baculovirus Insect Cells
|
|
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. Caprin-1/CAPRIN1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells ... |
|
TMPH-02187
|
Tenascin Protein, Human, Recombinant (E. coli, His)
GMEM,Glioma-associated-extracellular matrix antigen,Neuronec...
|
Human
|
E. coli
|
|
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. |
|
TMPH-03400
|
SLC17A6 Protein, Rat, Recombinant (His)
Slc17a6,Vesicular glutamate transporter 2,Solute carrier fam...
|
Rat
|
P. pastoris (Yeast)
|
|
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Involved in the regulation of retinal hyaloid vessel regression during postnatal development. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. SLC17A6 Protein, Rat, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 11.1 kDa an... |
|
TMPH-01209
|
DENND1A Protein, Human, Recombinant (His & SUMO)
KIAA1608,Connecdenn 1,DENN domain-containing protein 1A,DENN...
|
Human
|
E. coli
|
|
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P. DENND1A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6... |
|
TMPY-01172
|
CDH12 Protein, Human, Recombinant (His)
CDHB,cadherin 12, type 2 (N-cadherin 2)
|
Human
|
HEK293 Cells
|
|
Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subt... |
|
TMPH-01754
|
L1CAM Protein, Human, Recombinant (His & Myc)
Neural cell adhesion molecule L1,L1CAM
|
Human
|
HEK293 Cells
|
|
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. L1CAM Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-1... |
|
TMPK-01161
|
LAMP5 Protein, Mouse, Recombinant (hFc)
C20orf103,BADLAMP,dJ1119D9.3,LAMP-5,UNC-43,BAD-LAMP
|
Mouse
|
HEK293 Cells
|
|
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Mouse, Recombinant (hFc) is expressed in H... |
|
TMPK-01234
|
LAMP5 Protein, Human, Recombinant (His)
BAD-LAMP,BADLAMP,C20orf103,UNC-43,dJ1119D9.3,LAMP-5
|
Human
|
HEK293 Cells
|
|
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Human, Recombinant (His) is expressed in H... |
|
TMPY-01992
|
Kallikrein 8/KLK8 Protein, Human, Recombinant (His)
kallikrein-related peptidase 8,PRSS19,TADG14,NRPN,NP,HNP
|
Human
|
HEK293 Cells
|
|
Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease that is capable of degrading some proteins such as casein, fibrinogen, kininogen, fibronectin, and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-c... |
|
TMPJ-01401
|
NTNG1 Protein, Human, Recombinant (hFc)
NTNG1,LMNT1,Netrin-G1,Laminet-1
|
Human
|
HEK293 Cells
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Netrin-G1, known as NTNG-1, and is a member of the UNC-6/Netrin family of proteins. The NTNG1 gene is located on chromosome 1p13.3 and encodes a glycosylphosphatidylinositol protein anchored to the presynaptic membrane. Netrin G1 molecule has been described to be involved in axonal guidance/maintenance and axonal growth cone by specifically interacting with its receptor the Netrin G1 ligand (NGL-1), which is located at the postsynaptic compartment. Netrin Gs knockout mice have disturbed subdendr... |
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TMPJ-00883
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EGR1 Protein, Human, Recombinant (His)
zinc finger protein 225,NGFI-A,Zif268,Early growth response ...
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Human
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E. coli
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EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene. EGR-1 has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies su... |
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TMPK-01048
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Aggrecan Protein, Human, Recombinant (His)
CSPG1,MSK16,AGC1,ACAN
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Human
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HEK293 Cells
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Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vess... |
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TMPH-02162
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Synaptotagmin-1 Protein, Human, Recombinant (His)
SYT1,Synaptotagmin-1,p65,Synaptotagmin I
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Human
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E. coli
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Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at leas... |
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