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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8580 |
Bupranolol
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂,无固有的拟交感神经活性。 | |||
T8358 |
Fenoterol
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Fenoterol 是一种拟交感神经剂,是一种选择性的,具有口服活性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂,是一种有效的支气管扩张剂,可用于一种与哮喘、支气管炎和其他阻塞性气道疾病相关的支气管痉挛。 | |||
T0166 |
Pancuronium dibromide
Pancuronium bromide,Pavulon,泮库溴铵 |
AChR | Neuroscience |
Pancuronium dibromide (Pavulon) 是一种双季基类固醇,是一种神经肌肉松弛剂。它通过与乙酰胆碱竞争 nACh 受体上的结合位点来抑制神经肌肉传递。它还可抑制心脏毒蕈碱受体并具有拟交感神经作用。 | |||
T21445 |
Naphazoline
AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。 萘甲唑啉可用作血管收缩剂,当应用于粘膜时可快速减少肿胀。 | |||
T10631L |
Bucindolol Formate
Bucindolol Formate (71119-11-4 Free base) |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Bucindolol Formate 是一种具有内源性拟交感活性的β1 肾上腺素能受体 (β1-adrenergic receptor) 阻滞剂。Bucindolol 可用于心力衰竭疾病研究。 | |||
T0342 |
Carvedilol phosphate hemihydrate
Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐 |
VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy | Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors |
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物,是一种非选择性β/α-1受体阻断剂,具有抗高血压活性且缺乏内在拟交感神经活性。 | |||
T0279 |
Metaraminol tartrate
重酒石酸间羟胺,Metaradrine tartrate,Metaraminol bitartrate |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Metaraminol tartrate (Metaradrine tartrate) 是一种 α-肾上腺素能 (α-adrenergic) 激动剂,是一种直接或间接影响肾上腺素受体的拟交感神经胺,其中 α 效应占主导地位,可作为血管加压剂。 | |||
T10364 |
Arbutamine
GP 21213 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Arbutamine (GP 21213) 是一种新型非选择性β-肾上腺素受体激动剂,具有α-1-拟交感神经活性。Arbutamine 促进心脏应激,增加心率、心脏收缩力。Arbutamine 可用于研究心脏应激和冠状动脉疾病。 | |||
T1282 |
Carteolol hydrochloride
Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Carteolol hydrochloride (Abbott-43326) 是一种非选择性的β肾上腺素受体阻断剂。 | |||
T1012 |
Acebutolol hydrochloride
盐酸醋丁洛尔,Acebutolol HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂,用于研究高血压、心绞痛和心律失常。 | |||
T1577 |
Midodrine hydrochloride
Pro-Amatine,盐酸米多君 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Midodrine hydrochloride (Pro-Amatine) 通过去甘氨酸反应转化为其活性代谢物 desglymidodrine。Desglymidodrine 选择性地结合并激活小动脉和静脉血管系统的 α-1-肾上腺素能受体。这会导致平滑肌收缩并导致血压升高。 Desglymidodrine 在血脑屏障中的扩散很差,因此与对中枢神经系统的影响无关。Midodrine hydrochloride 是 midodrine 的盐酸盐形式,是一种直接作用的前药和拟交感神经药,具有抗低血压特性。 | |||
T1139 |
Salbutamol
Albuterol,沙丁胺醇,AH-3365 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。 | |||
T0871 |
Noradrenaline bitartrate
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Noradrenaline bitartrate 直接作用于 α 和 β 肾上腺素能受体。它是去甲肾上腺素的酒石酸氢盐,去甲肾上腺素是一种合成苯乙胺,可模拟内源性去甲肾上腺素的拟交感神经作用。临床上,去甲肾上腺素用作外周血管收缩剂,通过其α-肾上腺素能作用导致动脉和静脉床收缩。它还被用作通过其 β-1 肾上腺素能作用介导的强效正性肌力和变时性心脏刺激剂。 | |||
T0279L |
Metaraminol
Icoral B,Pressonex,CCRIS 8465,l-Metaraminol |
Others | Others |
Metaraminol is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. | |||
T70216 |
Clonazoline
|
Others | Others |
Clonazoline is a coronary vasodilator that is an imidazoline sympathomimetic, an alpha-adrenoreceptor agonist. It was used as a nasal decongestant and vasoconstrictor. | |||
T26762 |
Befunolol HCl
BFE60,Bentox,Befunolol hydrochloride,BFE-60,BFE 60 |
Others | Others |
Befunolol is a beta blocker with intrinsic sympathomimetic activity and also acts as a β adrenoreceptor partial agonist. | |||
T69270 |
Amezinium
|
Others | Others |
Amezinium is a sympathomimetic drug used for the treatment of low blood pressure. It has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake. | |||
T16043 |
Metaproterenol
Orciprenaline |
BCL | Apoptosis |
Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM). | |||
T21411L |
Isoproterenol bitartrate
|
Others | Others |
Isoproterenol bitartrate is a beta-sympathomimetic and an isopropyl analog of Epinephrine, which acts on the heart, bronchi, skeletal muscle, and alimentary tract. It is used mainly as a bronchodilator and heart stimulant. | |||
T69670 |
Clonazoline HCl
|
Others | Others |
Clonazoline HCl is the salt form of Clonazoline, a coronary vasodilator that is an imidazoline sympathomimetic, an alpha-adrenoreceptor agonist. It was used as a nasal decongestant and vasoconstrictor. | |||
T82564 |
Dibutepinephrine
|
Others | Others |
Dibutepinephrine是一种仿生拟交感神经药物,具有选择性地激活α和β肾上腺素能受体的作用。 | |||
T0279L2 |
Metaraminol hydrochloride
Metaraminol HCl |
Others | Others |
Metaraminol hydrochloride, used primarily as a vasoconstrictor in the treatment of HYPOTENSION, is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. | |||
T69697 |
Dioxethedrin HCl
|
Others | Others |
Dioxethedrin HCl is the ephedrine derivative. It is the beta-adrenergic agonist. As a bronchodilator and sympathomimetic agent is was used in antitussive syrup Bexol. | |||
T5450 |
DL-071-IT
Afurolol Hydrochloride,DL 071 IT |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
DL-071-IT (Afurolol Hydrochloride) 是一种有效的非选择性β-肾上腺素受体拮抗剂。 DL-071-IT 表现出内在的拟交感神经活性和弱的膜稳定活性。 | |||
T73216 |
Gepefrine
|
Others | Others |
Gepefrine为具口服活性的升压剂及拟交感神经作用剂,能有效改善动脉压早期直立性失调。 | |||
T69107 |
Doxaminol
|
Others | Others |
Doxaminol is a synthetic partial beta-adrenergic agonist with sympathomimetic activity. Doxaminol may bind to and stimulate beta-1-adrenergic receptors located in the myocardium. As a result, it leads to a positive inotropic effect and increases in cardiac output. | |||
T64309 |
Isometheptene mucate
|
Others | Others |
Isometheptene mucate 是一种拟交感神经剂,是间接作用的肾上腺素能受体 (adrenergic receptor) 激动剂,能够用于研究偏头痛。 | |||
T70506 |
Bupranolol HCl
|
Others | Others |
Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]be... | |||
T16431 |
Pamatolol
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Pamatolol 是一种具有选择性和有效性的 beta-adrenoceptor 拮抗剂,在体内外实验中尚未显示出拟交感活性。 | |||
T1244 |
Celiprolol hydrochloride
Selecor,Selectrol,盐酸塞利洛尔 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Celiprolol hydrochloride (Selectrol) 是一种选择性肾上腺素受体调节剂,是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂,具有部分β2激动剂活性,具有降压和抗心绞痛的作用。 | |||
T0143 |
Bisoprolol hemifumarate
富马酸比索洛尔,(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate) |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。 | |||
T69127 |
Moxisylyte
|
Others | Others |
Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction. It is an α1-adrenergic antagonist. Moxisylyte is also used for the short-term treatment of primary Reynaud's syndrome, a condition where the fingers and toes become discoloured in response to cold or emotional distress. Moxisylyte helps by improving blood circulation to the extremities. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomi... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1287 |
Synephrine
辛弗林,Oxedrine |
Endogenous Metabolite; Adrenergic Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Synephrine (Oxedrine) 是来自 Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂,是一种生物碱。它也是一种拟交感神经化合物,能够用于减肥。 | |||
T8149 |
Dobutamine hydrochloride
盐酸多巴酚丁胺,Dobutamine (hydrochloride) |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Dobutamine hydrochloride (Dobutamine(hydrochloride)) 是一种合成的儿茶酚胺,可作用于肾上腺素能受体α1-AR、β1-AR 和β2-AR,是一种选择性的 β1-AR 受体激动剂,对 α1-AR 和 β2-AR 作用相对较弱。它能够增加心输出量,矫正低灌注。 | |||
T6688 |
Synephrine hydrochloride
辛弗林盐酸盐,Oxedrine hydrochloride,Synephrine HCl |
Endogenous Metabolite; Adrenergic Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Synephrine hydrochloride (Oxedrine hydrochloride) 是一种来自Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂的生物碱,也是一种拟交感神经化合物,能够用于减肥。 | |||
T1071L |
DL-Adrenaline Hydrochloride
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
DL-Adrenaline Hydrochloride 是天然存在的拟交感神经胺的盐酸盐,具有收缩血管、降低眼内压的活性。 | |||
T3095 |
Tyramine
4-hydroxyphenethylamine,酪胺,para-tyramine,p-Tyramine,mydrial,Tocosine,Uteramine |
MAO; Endogenous Metabolite | Metabolism; Neuroscience |
Tyramine (Uteramine) 是天然存在于体内或某些食物中的氨基酸。Tyramine 有助于调节血压。 | |||
T75425 |
Synephrine hemitartrate
|
Others | Others |
Synephrine (Oxedrine) hemitartrate,一种生物碱,是一种来自Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂。Synephrine hemitartrate 是一种拟交感神经化合物,可用于减肥。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0175 |
Bisoprolol-d5 Hemifumarate
|
||
Bisoprolol-d5 Hemifumarate 是 Bisoprolol Hemifumarate 的氘代化合物。Bisoprolol Hemifumarate 的 CAS 号为 104344-23-2。Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。 | |||
TMID-0245 |
Pindolol-d7
|
||
Pindolol-d7 是 Pindolol 的氘代化合物。Pindolol 的 CAS 号为 13523-86-9。Pindolol 是一种非选择性β-阻断剂,局部的β-肾上腺素能受体激动剂活性,也作为5-HT1A受体部分拮抗剂,Ki为33nM。它是非心脏选择性的,具有内在的拟交感神经作用。 | |||
TMID-0236 |
Bisoprolol-d7 hemifumarate
|
||
Bisoprolol-d7 hemifumarate 是 Bisoprolol hemifumarate 的氘代化合物。Bisoprolol hemifumarate 的 CAS 号为 104344-23-2。Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。 | |||
TMIJ-0426 |
Celiprolol-d9 Hydrochloride
|
||
Celiprolol-d9 Hydrochloride 是 Celiprolol Hydrochloride 的氘代化合物。Celiprolol Hydrochloride 的 CAS 号为 57470-78-7。Celiprolol hydrochloride 是一种选择性肾上腺素受体调节剂,是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂,具有部分β2激动剂活性,具有降压和抗心绞痛的作用。 | |||
TMID-0233 |
Salbutamol-d9
|
||
Salbutamol-d9 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 | |||
TMIH-0512 |
Salbutamol-d3
|
||
Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 |