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Targets Recommended: ROCK Serine/threonin kinase Calcium Channel PKA PKC Autophagy

抑制剂 & 化合物

天然产物

重组蛋白

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1606	Fasudil HA-1077,AT877,法舒地尔	ROCK; Serine/threonin kinase; Calcium Channel; PKA; PKC; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	Fasudil (HA-1077) 是一种非特异性 RhoA/ROCK 抑制剂，也是 Ca2+通道拮抗剂和血管扩张剂。它对蛋白激酶有抑制作用，ROCK1 的 Ki 值为 0.33 μM，ROCK2 和 PKA、PKC、PKG 的 IC50值分别 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM。
T4276	Hydroxyfasudil Hydrochloride Hydroxyfasudil (HA-1100) HCl,羟基法舒地尔盐酸盐,RHO-激酶抑制剂,HA 1100 hydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) 是一种ROCK 抑制剂，对ROCK1和ROCK2的IC50值分别为 0.73 和 0.72 μM。
T4276L	Hydroxyfasudil Hydroxy-Fasudil,HA-1100,羟基法舒地尔	ROCK; PKA	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Hydroxyfasudil (Hydroxy-Fasudil) 是一种ROCK 抑制剂，对ROCK1和ROCK2的IC50分别为 0.73 和 0.72 μM。
T60924	Verosudil AR-12286	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Verosudil (AR-12286) 是一种高效的 Rho 激酶 (ROCK) 抑制剂，对 ROCK1 和 ROCK2 的 Ki 分别为 2 和 2 nM。AR-12286 可逆转类固醇诱导的小鼠眼内压，可通过增加眼房水通过小梁网流出来减缓眼压。
T38654	Cotosudil	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Cotosudil 是一种 ROCK 激酶抑制剂，具有抗高血压活性，可用于治疗或预防白内障、心血管疾病或神经退行性疾病或神经损伤引起的疾病或病症。
T10358	Netarsudil Dihydrochloride AR-13324 Dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) 是 Rho 相关蛋白激酶 (ROCK) 和去甲肾上腺素转运蛋白 (NET) 的抑制剂，可有效降低眼压 (IOP)。
T3060	Fasudil hydrochloride Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877	ROCK; Serine/threonin kinase; Calcium Channel; HIV Protease; PKA; PKC; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Fasudil hydrochloride (HA-1077) 是一种非特异性RhoA/ROCK 抑制剂，也抑制蛋白激酶，对 ROCK1、PKA、PKC 和 MLCK 的 Ki 值分别为 0.33 μM、1.0 μM、9.3 μM 和 55 μM。
TN2363	Sudan II 苏丹红Ⅱ,Solvent Orange 7,Sudan Red II	Others	Others
	Sudan II (Solvent Orange 7) 是一种染料。
T5612	Sudan III Solvent Red 23,Tetrazobenzene-β-naphthol,111440 Red,Sudan Red III,苏丹红Ⅲ	Others	Others
	Sudan III (Solvent Red 23) 是一种疏水性双偶氮染料。
T16950	Sudoxicam 舒多昔康,4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide	COX	Immunology/Inflammation; Neuroscience
	Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) 是一种可逆的 COX 拮抗剂，具有抗炎、抗水肿和解热特性。
T69665	Zelasudil RXC007	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Zelasudil (RXC007) 是一种 Rho 相关 (ROCK) 激酶抑制剂，可用于研究特发性肺纤维化和炎症。
T6867	Belumosudil KD025,Rezurock,ROCK inhibitor,SLx-2119	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Belumosudil (Rezurock) 是一种选择性的ROCK2抑制剂，对 ROCK1 和 ROCK2 的IC50值分别为 24 µM 和 105 nM，具有抗纤维化作用。
T3480	Sudoterb free base Sudoterb	ATPase	Membrane transporter/Ion channel
	Sudoterb free base (Sudoterb) 也称为 LL3858，是一种抗结核药物候选药物。
T77189	Sudubrilimab
	Sudubrilimab (HS636) 是一种针对 PDL1的 Ig G1-kappa 单克隆抗体。Sudubrilimab 在重链的 C 末端与 TGF-β1受体 Ⅱ 胞外域 (TGFBR2-ECD) 融合，可在免疫抑制性肿瘤微环境中隔离 PD-1/PD-L1通路和 TGF-β 生物活性。
T62608	Sovesudil hydrochloride	Others	Others
	Sovesudil (PHP-201) hydrochloride 是一种有效的、ATP 竞争性局部作用 Rho 激酶 (ROCK) 抑制剂，能够作用于 ROCK I (IC50: 3.7 nM) 和 ROCK II (IC50: 2.3 nM)。Sovesudil hydrochloride 能够降低眼压而不引起充血。
T62036	Sovesudil	Others	Others
	Sovesudil (PHP-201) 是有效的、ATP 竞争性局部作用 Rho 激酶(ROCK)抑制剂。Sovesudil 抑制 ROCK I 和 ROCK II 的IC50分别为 3.7 和 2.3 nM。Sovesudil 可以降低眼压而不引起充血。
T74418	Sudocetaxel	Others	Others
	Sudocetaxel 是一种可以用于pH 敏感的多西紫杉醇释放的微管解聚抑制剂。
T7492	Ripasudil free base K-115 (free base)	ROCK; Antibacterial	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Ripasudil free base (K-115 (free base)) 是一种ROCK 特异性抑制剂，能够抑制ROCK1和ROCK2的活性，IC50值分别为 51 和 19 nM。
T64582	Fasudil hydrochloride semihydrate	Others	Others
	Fasudil hydrochloride semihydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64582。
T71119	Netarsudil free base	Others	Others
	Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudi...
T71106	Cotosudil 2HCl	Others	Others
	Cotosudil 2HCl is the salt form of Cotosudil Free Base, a Rho-associated (ROCK) kinase inhibitor.
T125643	7-Methylsudachitin	Others	Others
	7-Methylsudachitin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125643，CAS号为 16520-78-8。
T61382	Fasudil dihydrochloride	Others	Others
	Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. It exhibits inhibitory effects on protein kinases, including ROCK1 with a Ki value of 0.33 μM, as well as ROCK2, PKA, PKC, and PKG with IC 50 values of 0.158 μM, 4.58 μM, 12.30 μM, and 1.650 μM, respectively. Additionally, Fasudil dihydrochloride demonstrates potent Ca 2+ channel blocking activity and acts as a vasodilator [1] [2] [3].
T3480L	Sudoterb HCl LL3858,LL-3858,Sudoterb dihydrchloride,LL 3858	Others	Others
	Sudoterb has anti-tubercular activity.
T76783	Moxetumomab pasudotox	Others; Antibody-Drug Conjugates (ADCs)	Antibody-drug Conjugate/ADC Related; Others
	Moxetumomab pasudotox (CAT 8015) 是一种抗CD22免疫毒素，含有抗CD22Fv 和Pseudomonas exotoxin。CD22是在多种恶性 B 细胞上表达的细胞表面受体。Moxetumomab pasudotox 可用于毛细胞白血病 (HCL) 的研究。
T76903	Alvircept sudotox
	Alvircept sudotox 是一种重组CD4，来源于Pneumonas aeruginosaexotoxin A。Alvircept sudotox 可用于HIV 感染的研究。
T39555	Belumosudil mesylate SLx-2119mesylate,KD025 mesylate	Others	Others
	Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC 50 s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties.
T124974	Natsudaidain	Others	Others
	Natsudaidain 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124974。
T10358L2	Netarsudil mesylate AR-13324 (mesylate)	Others	Others
	Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.
TP2371	Asudemotide Glu-tyr-tyr-glu-leu-phe-val-asn-ile
	Asudemotide is a bioactive chemical.
T70735	Verosudil hydrochloride	Others	Others
	Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG.
T70108	Fasudil hydrochloride hydrate	Others	Others
	Fasudil hydrochloride hydrate is an HCl salt of Fasudil -- a Rho-kinase (ROCK) inhibitor that has been shown to be effective in hindering the development of mature Cerebral Cavernous Malformation (CCM) lesions as well as reducing portal venous pressure in cirrhotic rats.

Cat. No.	Product Name	Target	Signaling Pathways
TN2362	Sudan I 苏丹红Ⅰ,苏丹红一号,Solvent Yellow 14	Others; Antibacterial	Microbiology/Virology; Others
	Sudan I (Solvent Yellow 14) 是一种偶氮共轭红色染料，抑制产气荚膜梭菌和鼠李糖菌的生长，可用于一些产品的添加剂，如油、溶剂或抛光剂。
TN2364	Sudan IV 苏丹红Ⅳ,Solvent Red 24,C.I. 26105	Others	Others
	Sudan IV (Solvent Red 24) 是脂溶性重氮染料，可用于冰冻或石蜡切片上，能够将脂类、甘油三酯和脂蛋白染色。
T8284	Sudan Orange G	Others	Others
	SUDAN ORANGE G 是一种天然产品。

Cat. No.	Product Name	Species	Expression System
TMPH-00524	ATP-dependent DNA helicase dda Protein, Enterobacteria phage T4, Recombinant (His) ATP-dependent DNA helicase dda,dda,sud	Enterobacteria phage T4	E. coli
	DNA helicase that stimulates viral DNA replication and recombination. Plays a role in T4 DNA replication initiation by selecting and activating DNA origins. Acts by dissociating and reassociating with the DNA molecule being unwound. Unwinds DNA as a monomer in a 5'-to-3' direction at a rate of 250 bp/s and can efficiently displace proteins from the DNA. ATP-dependent DNA helicase dda Protein, Enterobacteria phage T4, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. T...
TMPY-00235	Ebola virus EBOV (subtype Sudan, strain Gulu) GP/Glycoprotein Protein (His)	EBOV	HEK293 Cells
	Ebola virus EBOV (subtype Sudan, strain Gulu) GP/Glycoprotein Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.9 kDa and the accession number is A0A0E3KN50.
TMPY-00308	Ebola virus EBOV (Sudan ebolavirus, strain Gulu) Nucleoprotein/NP Protein (His) Sec61 alpha 1 subunit (S. cerevisiae),Sec61 α1 subunit (S. c...	EBOV	E. coli
	Ebola virus EBOV (Sudan ebolavirus, strain Gulu) Nucleoprotein/NP Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.8 kDa and the accession number is A0A2U8KL52.
TMPY-00238	Ebola virus EBOV (subtype Sudan, strain Gulu) GP1/Glycoprotein Protein (His)	EBOV	HEK293 Cells
	Ebola virus EBOV (subtype Sudan, strain Gulu) GP1/Glycoprotein Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.5 kDa and the accession number is A0A0E3KN50.
TMPY-00199	Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein/GP1 (mucin domain deleted) Protein (aa 1-320, His)	EBOV	Baculovirus Insect Cells
	Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein/GP1 (mucin domain deleted) Protein (aa 1-320, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 33.8 kDa and the accession number is Q7T9D9.1.
TMPY-04159	Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein/GP Protein (aa 1-637, His)	EBOV	Baculovirus Insect Cells
	Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein/GP Protein (aa 1-637, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 67.9 kDa and the accession number is A0A0E3KN50.
TMPY-00216	Ebola virus EBOV (subtype Sudan, strain Gulu) VP40/Matrix protein VP40 Protein (His)	EBOV	E. coli
	Ebola virus EBOV (subtype Sudan, strain Gulu) VP40/Matrix protein VP40 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34.5 kDa and the accession number is B0LPL6.
TMPY-00234	Ebola virus EBOV (subtype Sudan, strain Gulu) GP-RBD/Glycoprotein Protein (hFc)	EBOV	HEK293 Cells
	Ebola virus EBOV (subtype Sudan, strain Gulu) GP-RBD/Glycoprotein Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 59 kDa and the accession number is A0A0E3KN50.
TMPY-00281	Ebola virus EBOV (subtype Sudan, strain Gulu) VP40/Matrix protein VP40 Protein (His & MBP)	EBOV	E. coli
	Ebola virus EBOV (subtype Sudan, strain Gulu) VP40/Matrix protein VP40 Protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 79.1 kDa and the accession number is B0LPL6.
TMPY-04526	Ebola virus EBOV (Sudan ebolavirus, strain Gulu) Nucleoprotein/NP Protein (aa 361-738, His) Sec61 α1 subunit (S. cerevisiae),Sec61 alpha 1 subunit (S. c...	EBOV	E. coli
	Ebola virus EBOV (Sudan ebolavirus, strain Gulu) Nucleoprotein/NP Protein (aa 361-738, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 44.1 kDa and the accession number is A0A2U8KL52.

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0365	Sudan III-d6
	Sudan III-d6 是 Sudan III 的氘代化合物。Sudan III 的 CAS 号为 85-86-9。Solvent Red 23 是一种疏水性双偶氮染料。
T77211	Sudan I-d5
	Sudan I-d5为Sudan I的一种氘代物。作为一种偶氮共轭红色染料（red dye），Sudan I常被作为油、溶剂或抛光剂的添加剂使用。此外，Sudan I能够抑制产气荚膜梭菌及鼠李糖菌的生长。
TMIJ-0420	Sudan 4-d6 (naphthyl-d6)
	Sudan 4-d6 (naphthyl-d6) 是 Sudan 4 的氘代化合物。Sudan 4 的 CAS 号为 85-83-6。

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抑制剂 & 化合物

天然产物

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同位素标记化合物

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化合物

天然产物

重组蛋白

同位素标记化合物