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Search Results for " substance-p "

Targets Recommended: Others Neurokinin receptor

90

抑制剂 & 化合物

5

天然产物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7554	Substance P (7-11) Substance P 7-11(TFA)	Others; Neurokinin receptor	GPCR/G Protein; Neuroscience; Others
	Substance P (7-11) (Substance P 7-11(TFA)) 是神经肽物质P 的C-末端片段，可引起细胞内钙浓度的增加。
TP1087	Substance P Neurokinin P,P物质	Endogenous Metabolite; Neurokinin receptor	GPCR/G Protein; Metabolism; Neuroscience
	Substance P (Neurokinin P) 是一种神经肽，其内源性受体是神经激肽1受体，在中枢神经系统中作为神经递质和神经调节剂。
TP1932L1	[D-Trp7,9,10]-Substance P acetate	Others	Others
	[D-Trp7,9,10]-Substance P acetate 是 substance P 的类似物，substance P 可通过烟碱乙酰胆碱受体抑制离子电导。
TP1819L	Substance P 1-9 aceate	Neurotensin Receptor	GPCR/G Protein
	Substance P 1-9 aceate 是九肽，可减少豚鼠回肠和膀胱对 P 物质的失活。
TP1369L	[Sar9,Met(O2)11]-Substance P acetate [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) 是一种速激肽 NK1 受体选择性激动剂。它是一种选择性速激肽 NK1 受体激动剂。它和 septide（每只大鼠 10-100 pmol，i.c.v.）在增加平均动脉血压 (MAP) 和心率 (HR)，但它们的时间进程不同。两种激动剂都以剂量依赖性方式增加洗脸和吸鼻，而它是一种产生美容效果的化合物。
TP1862L	[Sar9] Substance P acetate(77128-75-7 free base)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Sar9] Substance P acetate(77128-75-7 free base) 是一种 NK-1 受体激动剂。 rNK1 特异性激动剂 [Sar-9,Met(O2)11]-SP 模拟了 SP 对孕酮代谢的作用。
T7675	Substance P (1-7) 2TFA(68060-49-1(free base))	Others	Others
	Substance P (1-7) 2TFA(68060-49-1(free base)) 是速激肽P（SP）蛋白水解降解后形成的主要生物活性代谢物，具有抗炎、抗伤害和抗痛觉过敏作用。
TP1931L1	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)	cholecystokinin	GPCR/G Protein
	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM)；减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。
T7828	[Sar9,Met(O2)11]-Substance P Bhsar-sp,NA,精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Sar9,Met(O2)11]-Substance P (NA) 是选择性速激肽NK1受体激动剂。
TP1862	[Sar9] Substance P
	[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
TP1831	[Nle11]-Substance P
	[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems. Substance P was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons.
TP1819	Substance P (1-9)
	Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder. Subtance P is responsible for a number of excitatory effects on both central and peripheral neurons.
T37110	Biotin-Substance P
	Biotin-Substance P 在中枢神经系统中作为神经递质和神经调节剂。神经激肽1受体 (neurokinin 1 receptor，NK1R)是 Biotin-Substance P 的内源性受体。
TP2155	Substance P TFA Neurokinin P TFA	Others	Others
	Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS, targeting the neurokinin 1 receptor (NK1-receptor, NK1R).
T7396	Substance P(1-7) Substance P 1-7	Others; Neurokinin receptor	GPCR/G Protein; Neuroscience; Others
	Substance P(1-7) (Substance P 1-7) 是神经肽P 物质的片段，可对孤束核产生抑制和缓和作用，具有抗炎、抗伤害和抗痛觉过敏的作用。
TP1932	[D-Trp7,9,10]-Substance P
	Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.
T34734	Substance P (1-4) SP(1-4)	Others	Others
	Substance P (1-4) is a substance P N-terminal tetrapeptide fragment.
TP1788	Substance P, Free Acid
	Substance P, Free Acid is a synthetic analog of native Substance P, however, it lacks the biological activity exhibited by Substance P.
T10121	Substance P Receptor Antagonist 1	Others	Others
	Substance P Receptor Antagonist 1 has the potential function in gastrointestinal disorders, inflammatory diseases, respiratory, and central nervous system disorders.
TP1034	Substance P (1-7)(TFA) (68060-49-1 free base) Substance P (1-7) Trifluoroacetate,Substance P (1-7)(TFA)
	Substance P (1-7)(TFA) is a fragment of the neuropeptide, substance P (SP).
TP1087L	Substance P acetate (87616-84-0 Free base)
	Substance P acetate (87616-84-0 Free base) 是一种十一肽（由11个氨基酸残基链组成的肽），属于速激肽神经肽家族。
TP1931	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
	Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In
TP1369	[Sar9,Met(O2)11]-Substance P TFA(110880-55-2,free) [Sar9,Met(O2)11]-Substance P TFA
	[Sar9,Met(O2)11]-Substance P TFA is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissi
TP2352	Septide Substance P (6-11), pyroglutamyl(6)-proline(9)-,6-Glp-9-pro-substance P (6-11)
	Septide is an NK1 receptor agonist acting at a site distinct from substance P.
T6905	Netupitant Ro 67-31898/000,奈妥吡坦,CID 6451149	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂，具有止吐作用，在 CHO 细胞中对 hNK1的 Ki 值为 0.95 nM。
T76449	Substance P (alligator)
	Substance P (alligator)，一种从鳄鱼中提取的神经肽，其氨基酸序列为Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2。
T76477	[His11]Substance P
	[His11]Substance P 是 Substance P (Substance P ) 的类似物。Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。
T76476	[Gly11] Substance P
	[Gly11] Substance P 是 Substance P (Substance P ) 的类似物。Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。
T76079	[Pro9]-Substance P
	[Pro9]-Substance P 是一种有效的、可逆的、选择性的NK-1速激肽受体激动剂，其EC50为 0.93 nM。
T76455	Substance P (4-11)
	Substance P (4-11) 是 Substance P (Substance P ) 的 C 末端片段，是一种 Substance P 激动剂，对NK1受体具有高度选择性。
T76484	[Tyr8,Nle11] Substance P
	[Tyr8,Nle11] Substance P 是 Substance P 的类似物。Substance P 是一种主要由神经元分泌的肽，参与许多生物学过程，包括痛觉和炎症。
T76453	Substance P (6-11)
	Substance P (6-11)，Substance P 的C末端六肽酰胺，可与NK-1速激肽受体结合，展现出对运动神经元的去极化作用以及降压效应。
T81079	Substance P (2-11)
	Substance P (2-11)为P物质（SP）片段肽，具有对豚鼠回肠产生收缩活性的特性。同时，Substance P (2-11)能够抑制3H SP在BBMEC单分子层中的渗透。
T76454	Substance P (5-11)
	Substance P (5-11) 是 Substance P (Substance P ) 的 C 端七肽，是一种神经肽，可以与NK-1速激肽受体结合。
T81078	Substance P (3-11)
	Substance P (3-11)，作为P 物质 (SP) 的片段肽，具备穿透血脑屏障的能力，且对豚鼠回肠显示出收缩活性。
T76405	[D-Trp2,7,9] Substance P
	[D-Trp2,7,9] Substance P 是一种速激肽 (Neurokinin Receptor) 拮抗剂，对 NK-1、NK-2和 NK-3受体的 Ki 值分别为 1 μM、1.3 μM 和 ~9 μM。
T76479	[MePhe8,Sar9] Substance P
	[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) 为 Substance P 的衍生物，属于在中枢神经系统中起到神经递质及神经调节剂作用的神经肽类。
T76483	[Sar4] Substance P (4-11)
	[Sar4] Substance P (4-11)为Substance P (4-11)的类似物，后者是Substance P (Substance P) C端片段并充当Substance P激动剂。
T81077	Substance P(1-4)
	Substance P(1-4)为一有效的神经激肽受体(NK-R)拮抗剂，具有调节正常造血功能并抑制内源性红细胞集落(EEC)形成的能力。
T1790	Fosaprepitant dimeglumine 福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。
T75963	Substance P(1-7) TFA
	Substance P(1-7) TFA，为神经肽P物质(SP)的一个片段，能对孤束核产生抑制和缓和效果。
T76403	[Glp5] Substance P (5-11)
	[Glp5] Substance P (5-11)为一八肽，为大鼠中枢神经系统(CNS)主要P物质片段之一，局部调节大鼠纹状体多巴胺释放。
T76450	Substance P-Gly-Lys-Arg
	Substance P-Gly-Lys-Arg，也称为 β-Preprotachykinin (58-71)，是 Substance P (Substance P ) 的类似物。
T76447	[DAla4] Substance P (4-11)
	[DAla4] Substance P (4-11) 作为Substance P的衍生物，能够有效抑制125I-Bolton Hunter标记的Eledoisin（IC50值为0.5 μM）及125I-Bolton Hunter标记的Substance P (IC50值为0.15 μM)与大鼠大脑皮层膜之间的结合。
T76402	[Glp6] Substance P (6-11)
	[Glp6] Substance P (6-11)为Substance P (6-11)的一种类似物，主要通过激活大鼠膀胱中的“隔膜敏感”速激素受体，促进[3H]-单磷酸肌醇 ([3H]-IP1)的生成。
T76462	[Glp5,Sar9] Substance P (5-11)
	[Glp5,Sar9] Substance P (5-11) 是一种Substance P 的类似物。
T76407	[D-Pro2,D-Trp7,9] Substance P
	[D-Pro2,D-Trp7,9] Substance P，是Substance P 的类似物，是一种弱激动剂，是一种有效的、特异性、竞争性的Substance P 拮抗剂。
T75769	[Sar9,Met(O2)11]-Substance P TFA	Others	Others
	[Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽NK1受体激动剂。
T83496	[D-Pro4,D-Trp7,9,10] Substance P (4-11)
	[D-Pro4,D-Trp7,9,10] Substance P (4-11) 是一种tachykinin拮抗剂，具有高效性。
T83495	[D-Pro4,D-Trp7,9] Substance P (4-11)
	[D-Pro4,D-Trp7,9]Substance P(4-11)为高效Substance P 拮抗剂，可降低血浆醛固酮(ALDO)浓度。

化合物

Substance P (7-11)

Cat.No: T7554

Synonym: Substance P 7-11(TFA)

Target: Others, Neurokinin receptor

Cat.No: TP1087

Synonym: Neurokinin P,P物质

Target: Endogenous Metabolite, Neurokinin receptor

[D-Trp7,9,10]-Substance P acetate

Cat.No: TP1932L1

Target: Others

Substance P 1-9 aceate

Cat.No: TP1819L

Target: Neurotensin Receptor

[Sar9,Met(O2)11]-Substance P acetate

Cat.No: TP1369L

Synonym: [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)

Target: Neurokinin receptor

[Sar9] Substance P acetate(77128-75-7 free base)

Cat.No: TP1862L

Target: Neurokinin receptor

Substance P (1-7) 2TFA(68060-49-1(free base))

Cat.No: T7675

Target: Others

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate

Cat.No: TP1931L1

Synonym: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)

Target: cholecystokinin

[Sar9,Met(O2)11]-Substance P

Cat.No: T7828

Synonym: Bhsar-sp,NA,精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺

Target: Neurokinin receptor

[Sar9] Substance P

Cat.No: TP1862

[Nle11]-Substance P

Cat.No: TP1831

Substance P (1-9)

Cat.No: TP1819

Biotin-Substance P

Cat.No: T37110

Substance P TFA

Cat.No: TP2155

Synonym: Neurokinin P TFA

Target: Others

Substance P(1-7)

Cat.No: T7396

Synonym: Substance P 1-7

Target: Others, Neurokinin receptor

[D-Trp7,9,10]-Substance P

Cat.No: TP1932

Substance P (1-4)

Cat.No: T34734

Synonym: SP(1-4)

Target: Others

Substance P, Free Acid

Cat.No: TP1788

Substance P Receptor Antagonist 1

Cat.No: T10121

Target: Others

Substance P (1-7)(TFA) (68060-49-1 free base)

Cat.No: TP1034

Synonym: Substance P (1-7) Trifluoroacetate,Substance P (1-7)(TFA)

Substance P acetate (87616-84-0 Free base)

Cat.No: TP1087L

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Cat.No: TP1931

[Sar9,Met(O2)11]-Substance P TFA(110880-55-2,free)

Cat.No: TP1369

Synonym: [Sar9,Met(O2)11]-Substance P TFA

Cat.No: TP2352

Synonym: Substance P (6-11), pyroglutamyl(6)-proline(9)-,6-Glp-9-pro-substance P (6-11)

Cat.No: T6905

Synonym: Ro 67-31898/000,奈妥吡坦,CID 6451149

Target: Neurokinin receptor

Substance P (alligator)

Cat.No: T76449

[His11]Substance P

Cat.No: T76477

[Gly11] Substance P

Cat.No: T76476

[Pro9]-Substance P

Cat.No: T76079

Substance P (4-11)

Cat.No: T76455

[Tyr8,Nle11] Substance P

Cat.No: T76484

Substance P (6-11)

Cat.No: T76453

Substance P (2-11)

Cat.No: T81079

Substance P (5-11)

Cat.No: T76454

Substance P (3-11)

Cat.No: T81078

[D-Trp2,7,9] Substance P

Cat.No: T76405

[MePhe8,Sar9] Substance P

Cat.No: T76479

[Sar4] Substance P (4-11)

Cat.No: T76483

Substance P(1-4)

Cat.No: T81077

Fosaprepitant dimeglumine

Cat.No: T1790

Synonym: 福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt

Target: Neurokinin receptor

Substance P(1-7) TFA

Cat.No: T75963

[Glp5] Substance P (5-11)

Cat.No: T76403

Substance P-Gly-Lys-Arg

Cat.No: T76450

[DAla4] Substance P (4-11)

Cat.No: T76447

[Glp6] Substance P (6-11)

Cat.No: T76402

[Glp5,Sar9] Substance P (5-11)

Cat.No: T76462

[D-Pro2,D-Trp7,9] Substance P

Cat.No: T76407

[Sar9,Met(O2)11]-Substance P TFA

Cat.No: T75769

Target: Others

[D-Pro4,D-Trp7,9,10] Substance P (4-11)

Cat.No: T83496

[D-Pro4,D-Trp7,9] Substance P (4-11)

Cat.No: T83495

Cat. No.	Product Name	Target	Signaling Pathways
T4406	2,6-Dimethylbenzoquinone m-Xyloquinone,2,6-二甲基苯醌,2,6-Dimethylquinone	Others	Others
	2,6-Dimethylbenzoquinone (2,6-Dimethylquinone) 是一种苯醌，一种存在于呕吐萝芙木和 Tibouchina pulchra 中的化合物。在生理浓度下 2, 6-Dimethoxy-p-benzoquinone 是一种抗菌物质。
T5S1286	(+)-Columbianetin 二氢山芹醇,(S)-Columbianetin,Columbianetin	Antifungal	Microbiology/Virology
	(+)-Columbianetin ((S)-Columbianetin) 是 Columbianetin 的异构体。其中Columbianetin 是一种植物抗毒素，与芹菜贮藏过程中对病原体的抗性有关，具有良好的抗真菌和抗炎作用。
TN6064	Ditryptophenaline
	Ditryptophenaline inhibits substance P receptor for potential analgesic and anti-inflammatory activity.
T71833	Acetylaszonalenin	Others	Others
	Acetylaszonalenin is a fungal metabolite that has been found in A. flavipes.1 It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P with a Ki value of 170 μM.
T38033	Benzomalvin B	Others	Others
	Benzomalvin B is a fungal metabolite originally isolated from Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 μg/ml.

天然产物

2,6-Dimethylbenzoquinone

Cat.No: T4406

Synonym: m-Xyloquinone,2,6-二甲基苯醌,2,6-Dimethylquinone

Target: Others

(+)-Columbianetin

Cat.No: T5S1286

Synonym: 二氢山芹醇,(S)-Columbianetin,Columbianetin

Target: Antifungal

Ditryptophenaline

Cat.No: TN6064

Acetylaszonalenin

Cat.No: T71833

Target: Others

Cat.No: T38033

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02147	TACR1 Protein, Human, Recombinant (GST) Substance-P receptor,Tachykinin r...	Human	E. coli
	This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. TACR1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 30.1 kDa and the accession number is P25103.
TMPJ-00892	TAC1 Protein, Human, Recombinant (His) PPT,Protachykinin-1,TAC1	Human	E. coli
	Protachykinin-1(TAC1) is a secreted protein and belongs to the tachykinin family. TAC1 is encoded by the TAC1 gene. This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretag...
TMPY-03269	Prolyl Endopeptidase Protein, Mouse, Recombinant (His) PEP,AI450383,AI047692,D10Wsu136e,p	Mouse	Baculovirus Insect Cells
	Prolyl endopeptidase, also known as PREP, belongs to a distinct class of serine peptidases. It is a large cytosolic enzyme which was first described in the cytosol of rabbit brain as an oligopeptidase. Prolyl endopeptidase degrades the nonapeptide bradykinin at the Pro-Phe bond. It is involved in the maturation and degradation of peptide hormones and neuropeptides such as alpha-melanocyte-stimulating hormone, luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone, angiotens...

重组蛋白

TACR1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02147

Species: Human

Expression System: E. coli

TAC1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00892

Species: Human

Expression System: E. coli

Prolyl Endopeptidase Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03269

Species: Mouse

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0519	Fosaprepitant-d4 Dimeglumine
	Fosaprepitant-d4 Dimeglumine 是 Fosaprepitant Dimeglumine 的氘代化合物。Fosaprepitant Dimeglumine 的 CAS 号为 265121-04-8。Fosaprepitant dimeglumine 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。

同位素标记化合物

Fosaprepitant-d4 Dimeglumine

Cat.No: TMIJ-0519

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