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Search Results for " state-dependent "

13

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22675	Co 102862 V 102862	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Co 102862 是一种电压门控钠通道阻滞剂。 Co 102862 可用于抗惊厥的研究。
T8711	PF-05186462 PF-05150122	Sodium Channel	Membrane transporter/Ion channel
	PF-05186462 (PF-05150122)是选择性的人Nav1.7电压依赖性钠通道抑制剂，IC50为 21 nM，与其他钠通道 (Nav 1.1、1.2、1.3、1.4、1.5、1.6 和 1.8) 相比，它对 Nav1.7显示出显著的选择性。PF-05186462在急性或慢性疼痛中具有研究价值。
T33816	Ordopidine ACR-325,ACR 325,ACR325	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Ordopidine (ACR325) 是一种多巴胺能稳定剂，可抑制精神刺激剂引起的多动症，并在不活动时刺激行为。Ordopidine 在体外作为多巴胺 D2 受体拮抗剂起作用，尽管亲和力低，但其依赖于特定状态的行为效应特征是 D2 受体拮抗剂所不具备的。
T14884	CBR-5884	Others; Dehydrogenase	Metabolism; Others
	CBR-5884 是一种磷酸甘油酸脱氢酶抑制剂，IC50为 33 μM。它抑制癌细胞中的丝氨酸合成，选择性地抑制黑素瘤和乳腺癌细胞系的增殖，对具有高丝氨酸生物合成活性的癌细胞系有选择性毒性。
T24902	TROX-1 TROX1,TROX 1	Others	Others
	TROX-1 is the activation state-dependent Cav2 channel antagonist.
T14992	Raxatrigine hydrochloride GSK-1014802 hydrochloride,CNV1014802 (hydrochloride)	Others	Others
	Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor.
T7352L	Pridopidine hydrochloride ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride	Others	Others
	Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor activity in a state-dependent way t
T71239	CNV-2197944	Others	Others
	CNV-2197944 is a novel, small molecule, state-dependent calcium channel blocker, designed to selectively inhibit highly active Cav2.2 channels.
T23652	AFD-21 AFD21,NS-2 Class 1 antiarrhythmic agent	Others	Others
	AFD-21是一种 I 类抗心律失常药物。它在钠通道失活状态下与钠通道结合，对钠通道具有使用和电压依赖性抑制作用，其解结合率与具有中等动力学的I 类抗心律失常药物相当。
T79280	Nav1.3 channel inhibitor 1	Sodium Channel	Membrane transporter/Ion channel
	Nav1.3 channel inhibitor 1 (化合物 15b) 为状态依赖性电压门控钠通道Nav1.3的抑制剂，具有IC50值为20 nM。该化合物能穿透血脑屏障，适用于神经系统疾病研究。
T70004	APS-2-79	Others	Others
	APS-2-79 是一种 KSR 依赖性的MEK 拮抗剂。APS-2-79 与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2，IC50为 120 nM。APS-2-79 与 KSR 结合可将 KSR 固定在一个非活性的状态，使其无法再结合RAF 和激活MEK，从而阻断了 Ras-MAPK 信号通路。
T35946	17(R)-Resolvin D1 Aspirin-triggered Resolvin D1,17(R)-Resolvin D1	Others	Others
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the ear...
T36717	RWJ-56110 dihydrochloride	Others	Others
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

Cat.No: T22675

Synonym: V 102862

Target: Others, Sodium Channel

Cat.No: T8711

Synonym: PF-05150122

Target: Sodium Channel

Cat.No: T33816

Synonym: ACR-325,ACR 325,ACR325

Target: Dopamine Receptor

Cat.No: T14884

Target: Others, Dehydrogenase

Cat.No: T24902

Synonym: TROX1,TROX 1

Target: Others

Raxatrigine hydrochloride

Cat.No: T14992

Synonym: GSK-1014802 hydrochloride,CNV1014802 (hydrochloride)

Target: Others

Pridopidine hydrochloride

Cat.No: T7352L

Synonym: ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride

Target: Others

Cat.No: T71239

Target: Others

Cat.No: T23652

Synonym: AFD21,NS-2 Class 1 antiarrhythmic agent

Target: Others

Nav1.3 channel inhibitor 1

Cat.No: T79280

Target: Sodium Channel

Cat.No: T70004

Target: Others

17(R)-Resolvin D1

Cat.No: T35946

Synonym: Aspirin-triggered Resolvin D1,17(R)-Resolvin D1

Target: Others

RWJ-56110 dihydrochloride

Cat.No: T36717

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2830	26-Nor-8-oxo-alpha-onocerin	Others	Others
	26-Nor-8-oxo-alpha-onocerin can promote the osteoblast proliferation rate, the effect is time-dependent,concentration-dependent and differentiation state-dependent.
TN3844	Didrovaltrate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Didrovaltrate shows cytotoxic against human cancer cell lines. Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in its inactive state, which may contribute to its cardiovascular effect.

天然产物

26-Nor-8-oxo-alpha-onocerin

Cat.No: TN2830

Target: Others

Cat.No: TN3844

Target: Calcium Channel

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