26
2
20
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1312 |
Nafcillin sodium monohydrate
CL 8491,萘夫西林钠,nafcillin sodium |
Antibacterial; Antibiotic | Microbiology/Virology |
Nafcillin sodium monohydrate (CL 8491) 是一种抗生素,是可逆的β-lactamase 抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。 | |||
T62665 |
Antistaphylococcal agent 2
|
Others | Others |
Antistaphylococcal agent 2 是一种抗葡萄球菌的治疗剂。 | |||
T61855 |
Antistaphylococcal agent 1
|
Others | Others |
Antistaphylococcal agent 1 是一种抗葡萄球菌的治疗剂。 | |||
T39886 |
Antistaphylococcal agent 3
|
Others | Others |
Antistaphylococcal agent 3 is an antistaphylococcal therapeutic agent. | |||
TP1699L |
SEB Domain 144-153 acetate
SEB Domain 144-153 acetate(210229-94-0 free base) |
Others | Others |
SEB Domain 144-153 acetate(210229-94-0 free base) 是葡萄球菌肠毒素 B 结构域氨基酸残基 163-172。它已被证明可抑制多种葡萄球菌肠毒素、SEA、SEE 和 TSST-1 的转胞吞作用。 | |||
T22297 |
Clindamycin hydrochloride monohydrate
Clindamycin alcoholate |
Antibiotic | Microbiology/Virology |
Clindamycin hydrochloride monohydrate(Clindamycin alcoholate)是一种口服蛋白质合成抑制剂,具有在金黄色葡萄球菌中以亚抑制浓度(sub-MICs)抑制毒力因子表达的能力。其抗性来源于50S核糖体亚基(23S rRNA)的抗生素结合位点通过酶促甲基化。此外,Clindamycin hydrochloride monohydrate能显著减少杀白细胞毒素(PVL)、毒性休克-葡萄球菌毒素(TSST-1)或α-溶血素(Hla)的产生。 | |||
T41142 |
EM 163
|
IL Receptor; p38 MAPK; MyD88 | Immunology/Inflammation; MAPK |
EM 163是一种 TIR-TIR 相互作用抑制剂,它是MyD88蛋白的TIR(Toll/白细胞介素-1受体)结构域拟态。EM 163针对IL-1受体中的TIR 结构域,阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B(SEB)引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中,EM 163阻断p38的激活和IL-1β对化学诱导的长期电位(LTP)引发的蛋白质合成的抑制作用。 | |||
TP1699 |
SEB Domain (144-153)
SEB Domain 144-153 |
||
SEB Domain (144-153) peptide is Staphylococcal Enterotoxin B domain amino acid residue 163-172. SEB Domain (144-153) has been shown to inhibit transcytosis of multiple staphylococcal enterotoxins, SEA, SEE, and TSST-1. | |||
T27559 |
HT-61
HY-50A,HY50A,HY 50A |
Others | Others |
HT-61, a pyrroloquinolone antibiotic, is used potentially for the treatment of staphylococcal infections. | |||
T26093 |
Ristocetin
Spontin |
Others | Others |
Ristocetin is an antibiotic isolated from Amycolatopsis lurida that is previously used to the treatment of staphylococcal infections. It is no longer used clinically because it caused thrombocytopenia and platelet agglutination. | |||
T82893 |
Bevifimod
PRTX-100 |
||
Bevifimod (PRTX-100),一种高度纯化的葡萄球菌蛋白A (SpA),主要用于特发性血小板减少性紫癜(ITP)的研究。 | |||
TP2163 |
SEB Domain 144-153 TFA(210229-94-0 free base)
SEB Domain (144-153) (TFA) |
Others | Others |
SEB Domain 144-153 TFA is Staphylococcal Enterotoxin B domain amino acid residue 144-153. It inhibits transcytosis of multiple staphylococcal enterotoxins, SEE, SEA, and TSST-1. | |||
T25027 |
Albocycline
TA-2407,Ingramycin |
Others | Others |
Albocycline is a Macrolide antibiotic from Streptomyces bruneogriseus nov. sp. MCRL-0129; specifically anti-staphylococcal, including antibiotic-resistant strains. | |||
T75294 |
Nafcillin sodium
|
Others | Others |
Nafcillin sodium 是一种抗生素,是可逆的β-lactamase 抑制剂。Nafcillin sodium 可用于葡萄球菌感染的研究。 | |||
T76822 | Pagibaximab | ||
Pagibaximab为一种嵌合IgG1抗体,针对金黄色葡萄球菌与表皮链球菌的表面脂肪酸成分具有特异性识别能力。其主要应用于预防葡萄球菌所引起的败血症。 | |||
T77215 |
Kanamycins sulfate
|
Others | Others |
Kanamycin sulfate,一种广谱性抗生素,适用于治疗严重的葡萄球菌或革兰氏阴性杆菌感染,但具有一定的耳毒性。 | |||
T61274 |
PC190723
|
Others | Others |
PC190723 (Compound 2) 是一种细菌细胞分裂蛋白 FtsZ 抑制剂,IC50值为 55 ng/ml。FtsZ-IN-3 具有抗葡萄球菌活性,对 MSSA 和 MRSA 的MIC 值均为 1 μg/ml。 | |||
TP1583 |
HER2/neu (654-662) GP2
|
||
Affibody (affibody) ligands that are specific for the extracellular domain of human epidermal growth factor receptor 2 (HER2/neu) have been selected by phage display technology from a combinatorial protein library based on the 58 amino acid residue staphy | |||
T76570 |
PSM-β
|
||
PSM-β, 一种从表皮葡萄球菌中分离的活性肽,属于葡萄球菌毒素类似物,并且是酚溶性调节蛋白。该化合物展现出抑菌作用和低溶血性。 | |||
T19678 |
Cefaloridine
Cephaloridine,Sch 11527 |
Others | Others |
Cefaloridine is a first-generation semisynthetic derivative of cephalosporin C. It is unique among cephalosporins in that it exists as a zwitterion. Cephaloridine was very effective to cure pneumococcal pneumonia. It has a high clinical and bacteriologica | |||
T63370 |
FtsZ-IN-2
|
Others | Others |
FtsZ-IN-2 是细菌细胞分裂蛋白 FtsZ 抑制剂,对 GTPase 的活性具有抑制作用。FtsZ-IN-2 表现出抗葡萄球菌作用,对 MSSA 和 MRSA 的MIC 值均为 2 μg/ml。 | |||
T79409 |
Antibacterial agent 154
|
Others | Others |
Antibacterialagent 154(compound 7)作为Fluoroquinolones类衍生物,适用于口服的抗菌治疗。它针对革兰氏阳性菌与阴性菌具有抑制作用,并在小鼠葡萄球菌败血症模型中显示出了体内效力。 | |||
T77111 | Omodenbamab | ||
Omodenbamab 是一种抗 SpA(葡萄球菌蛋白 A) 人源化单克隆抗体,KD 值为 0.0467 nM。Omodenbamab 通过靶向细胞壁部分蛋白 A (SpA) 来规避关键的 S. aureus 逃避机制。Omodenbamab 可用于 S. aureus 血流感染的研究。 | |||
T74803 |
Levonadifloxacin
|
Others | Others |
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771),作为一种宽谱抗葡萄球菌药物,对甲氧西林敏感金黄色葡萄球菌(MSSA)及对甲氧西林耐药金黄色葡萄球菌(MRSA)显示出显著的抗菌活性,并能有效减少THP-1单核细胞对MRSA和MSSA菌株的吞噬。 | |||
T73824 |
Thymidine 3',5'-diphosphate tetrasodium
|
Others | Others |
Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium,为一种选择性抑制剂,主要针对葡萄球菌核酸酶及含1的都铎结构域(SND1,MicroRNA调控复合体RISC亚基)和[3,5-2H2]酪氨酸核酸酶([3,5-2H2] tyrosyl nuclease)。此化合物还展示了抗肿瘤活性,并可在生化反应中作为催化剂使用。 | |||
T38178 |
Ristocetin A (sulfate)
Ristomycin III |
Others | Others |
Ristocetin A, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism Nocardia lurida[1]. Ristocetin A is currently in clinical use to treat bacterial infections [1]. Ristocetin A is an antibiotic which can be used to treat staphylococcal infections. The side effects of ristocetin A include thrombocytopenia and platelet agglutination. Ristocetin A has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. These t... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1235 |
Lincomycin hydrochloride monohydrate
洁霉素盐酸盐,林可霉素,Lincomycin hydrochloride hydrate |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Lincomycin hydrochloride monohydrate (Lincomycin hydrochloride hydrate) 是一种窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌的作用效果很好, 主要抑制细菌细胞蛋白质的合成。 | |||
TN1165 |
(Rac)-Myrislignan
1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟 |
Others | Others |
1-(3,4-Dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol shows anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the minimum inhibitory concentrations (MIC |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03578 |
SCIN Protein, S. aureus, Recombinant (His & Myc)
scn,Staphylococcal complement inhibitor |
Staphylococcus aureus | E. coli |
Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses. SCIN Protein, S. aureus, ... | |||
TMPH-03577 |
Staphopain B Protein, S. aureus, Recombinant (GST)
Staphopain B,sspB,Staphylopain B,Staphylococcal cys... |
Staphylococcus aureus | E. coli |
Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner. Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils. Cleaves host galectin-3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin. Staphopain B Protein, S.... | |||
TMPH-03570 |
IsaA Protein, S. aureus, Recombinant (His & Myc)
Probable transglycosylase IsaA,Immunodominant staphyloco... |
Staphylococcus aureus | E. coli |
Is able to cleave peptidoglycan. IsaA Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.8 kDa and the accession number is P60157. | |||
TMPH-03576 |
Staphopain A Protein, S. aureus, Recombinant (His & Myc)
Staphopain A,Staphylopain A,sspP,Staphylococcal cys... |
Staphylococcus aureus | E. coli |
Staphopain A Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.4 kDa and the accession number is P81297. | |||
TMPH-03560 |
lsdA Protein, S. aureus, Recombinant (His & Myc)
Iron-regulated surface determinant protein A,Staphylococ... |
Staphylococcus aureus | E. coli |
lsdA Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.1 kDa and the accession number is Q6GA85. | |||
TMPH-03561 |
lsdB Protein, S. aureus, Recombinant (His & SUMO)
Fur-regulated protein B,Iron-regulated surface determinant p... |
Staphylococcus aureus | E. coli |
Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source. Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization. Promotes also resistance to hydrogen peroxide and killing by neutrophils. lsdB Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is ... | |||
TMPY-00105 |
Recombinant Protein G
|
E. coli | |
Protein G is a bacterial cell wall protein expressed at the cell surface of certain group C and group G Streptococcal strains. It has affinity for both Fab- and Fc-fragments of human IgG by independent and separate binding sites. Binding to the Fc region of immunoglobulins from several species by a non-immune mechanism exhibits great affinity for almost all mammalian immunoglobulin G (IgG) classes, including all human IgG subclasses (IgG1, IgG2, IgG3 and IgG4) and also rabbit, mouse, and goat Ig... | |||
TMPH-03548 |
Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His)
entG,Enterotoxin type G,SEG |
Staphylococcus aureus | P. pastoris (Yeast) |
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.0 kDa and the accession number is P0A0L7. | |||
TMPH-03545 |
Enterotoxin type E Protein, S. aureus, Recombinant (His & SUMO)
Enterotoxin type E,SEE,entE |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. | |||
TMPH-03551 |
Exfoliative toxin A Protein, S. aureus, Recombinant (His)
eta,Epidermolytic toxin A,Exfoliative toxin A |
Staphylococcus aureus | E. coli |
Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS). | |||
TMPH-03546 |
Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His & SUMO)
Enterotoxin type G,entG,SEG |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.0 kDa and the accession number is P0A0L7. | |||
TMPH-03541 |
Enterotoxin type C-2 Protein, S. aureus, Recombinant (His & SUMO)
Enterotoxin type C-2,SEC2,entC2 |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-2 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system wi... | |||
TMPH-03547 |
Enterotoxin type G Protein, S. aureus (strain Mu50/ATCC 700699), Recombinant (His & SUMO)
SEG,Enterotoxin type G,entG |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S. aureus (strain Mu50/ATCC 700699), Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.0 kDa and the accession number is P0A0L6. | |||
TMPH-03539 |
Enterotoxin type B Protein, S. aureus, Recombinant (His)
Enterotoxin type B,SEB,entB |
Staphylococcus aureus | P. pastoris (Yeast) |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. | |||
TMPH-03544 |
Enterotoxin type D Protein, S. aureus, Recombinant (His & SUMO)
entD,SED,Enterotoxin type D |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. In addition, induces B-cell proliferation and differentiation in the presence of T-cells. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type D P... | |||
TMPH-03542 |
Enterotoxin type C-2 Protein, S. aureus, Recombinant
Enterotoxin type C-2,entC2,SEC2 |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-2 Protein, S. aureus, Recombinant is expressed in E. coli expression system. The predicted ... | |||
TMPH-03543 |
Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO)
SEC3,entC3,Enterotoxin type C-3 |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system wi... | |||
TMPH-03540 |
Enterotoxin type B Protein, S. aureus, Recombinant (GST)
entB,Enterotoxin type B,SEB |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type B Protein, S. aureus, Recombinant (GST) is expressed in E. coli expression system with N-GST ... | |||
TMPH-03552 |
Exfoliative toxin B Protein, S. aureus, Recombinant (His & Myc)
etb,Epidermolytic toxin B,Exfoliative toxin B |
Staphylococcus aureus | E. coli |
Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS). Exfoliative toxin B Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.8 kDa and the accession number is P09332. | |||
TMPJ-00751 |
IgG4 hFc Protein, Human, Recombinant (aa 99-326)
IgG4 Fc,Ig γ-4 chain C region,Ig gamma-4 chain C region |
Human | HEK293 Cells |
As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetram... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0281 |
Lincomycin-d3
|
||
Lincomycin-d3 是 Lincomycin 的氘代化合物。Lincomycin 的 CAS 号为 7179-49-9。Lincomycin hydrochloride monohydrate 是一种窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌的作用效果很好, 主要抑制细菌细胞蛋白质的合成。 | |||
TMIJ-0340 |
Lincomycin-13C-d3
|
||
Lincomycin-13C-d3 是 Lincomycin 的 13C 和氘代化合物。Lincomycin 的 CAS 号为 7179-49-9。Lincomycin hydrochloride monohydrate 是一种窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌的作用效果很好, 主要抑制细菌细胞蛋白质的合成。 |