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Search Results for " spindle "

Targets Recommended: Kinesin

49

抑制剂 & 化合物

6

天然产物

1

化合物库

18

重组蛋白

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Cat. No.	Product Name
L1110	微管靶向化合物库		142 compounds
	142 种靶向微管的分子集合，用于高通量筛选和高内涵筛选；

化合物库

微管靶向化合物库

Cat.No: L1110

Compounds: 142

Cat. No.	Product Name	Target	Signaling Pathways
T3434	BAY1217389	Kinesin	Cytoskeletal Signaling
	BAY1217389 是一种有效的选择性单极纺锤体 1 (MPS1) 激酶抑制剂，IC50值小于10 nM。
T16130	Mps1-IN-3	Kinesin	Cytoskeletal Signaling
	Mps1-IN-3 是一种有效的选择性 MPS1 激酶抑制剂，IC50值为 50 nM。
T2689	AZ3146 AZ 3146	Kinesin	Cytoskeletal Signaling
	AZ3146 是一种选择性 Mps1 抑制剂，IC50为 35 nM。
T2313	MPI-0479605	Apoptosis; Kinesin	Apoptosis; Cytoskeletal Signaling
	MPI0479605 是一种选择性的，ATP 竞争性的 Mps1抑制剂，IC50值为 1.8 nM。
T1839	Mps1-IN-2	Kinesin; PLK	Cell Cycle/Checkpoint; Cytoskeletal Signaling
	Mps1-IN-2 是一种 ATP 竞争性Mps1/Plk1选择性双重抑制剂，对 Mps1 的IC50和Kd 值分别为 145 和 12 nM，对 Plk1 的Kd 值为 61 nM。
T12237	NMS-P715	Casein Kinase; Kinesin; MELK; MAPK	Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	NMS-P715 是一种 ATP 竞争性MPS1选择性抑制剂，IC50值为 182 nM。
T8487	Empesertib BAY 1161909	Kinesin	Cytoskeletal Signaling
	Empesertib (BAY 1161909) 是一种口服有效的Mps1抑制剂，IC50值小于1 nM，具有潜在的抗肿瘤活性。
T14765	BOS-172722	Kinesin	Cytoskeletal Signaling
	BOS-172722 是一种单极纺锤体 1 (MPS1) 检查点抑制剂，对MPS1 (1 mM ATP) 和P-MPS1 的IC50值分别为 11 nM 和 63 nM。它可研究多种乳腺癌。
T8492	BO-264	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	BO-264 是一种有口服活性的转化酸性卷曲螺旋 3 抑制剂，可特异性阻断 FGFR3-TACC3融合蛋白的功能。它诱导纺锤体检查点依赖的有丝分裂阻滞，DNA 损伤和细胞凋亡，具有广谱抗肿瘤活性。
T2241	Alisertib MLN 8237,4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸	Apoptosis; Aurora Kinase; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Alisertib (MLN 8237) 是一种 Aurora A 激酶抑制剂 (IC50=1.2 nM)，具有口服活性和选择性。Alisertib 具有抗肿瘤活性，可以诱导细胞凋亡和自噬，诱导细胞周期阻滞。
T2255	SB-743921 hydrochloride SB743921 HCl,SB743921	Kinesin; KSP	Cell Cycle/Checkpoint; Cytoskeletal Signaling
	SB-743921 hydrochloride (SB743921 HCl) 是一种有效的驱动蛋白纺锤体蛋白 KSP 抑制剂，Ki 值为 0.1 nM。
T9682	AZD-4877 AZD4877	Apoptosis; Kinesin	Apoptosis; Cytoskeletal Signaling
	AZD-4877 是一种高效的纺锤体驱动蛋白 (Eg5) 抑制剂，对其 IC50 值为 2 nM。 AZD-4877 是 Ispinesib 的另一种构型，能够抑制细胞有丝分裂，诱导形成单极纺锤体表型，介导细胞凋亡(Apoptosis)。 AZD-4877 具有抗肿瘤活性，对循环外周血单核细胞 (PBMC)有抑制作用。
T9831	MKC-1 Ro-31-7453	Apoptosis; Akt; Microtubule Associated; mTOR	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	MKC-1 (Ro-31-7453) 是一种口服生物可利用的小分子双吲哚基马来酰亚胺细胞周期抑制剂，具有潜在的抗肿瘤活性。
T5699	SSE15206	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	SSE15206 是一种克服多药耐药性的微管聚合抑制剂，其在 HCT116 细胞中的 GI50值为 197 nM。由于癌细胞中纺锤体形成不完整，导致 G2/M 停滞，有丝分裂异常。
T2103	Ispinesib 伊匹尼塞,伊斯平斯,CK0238273,SB-715992	Apoptosis; Kinesin; KSP	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling
	Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂，具有抗肿瘤特性。
TQ0318	Filanesib ARRY-520,ARRY 520	KSP	Cell Cycle/Checkpoint
	Filanesib (ARRY 520) 是一种选择性的驱动蛋白纺锤体蛋白(KSP)的抑制剂(IC50 = 6 nM)，具有强大的抗增殖活性。
TQ0318L	ARRY 520 hydrochloride	KSP	Cell Cycle/Checkpoint
	ARRY 520 hydrochloride 是一种驱动蛋白纺锤体蛋白 (KSP) 抑制剂。它通过凋亡诱导细胞死亡，并具有有效的抗增殖活性。
T2090	Lexibulin CYT-997	Apoptosis; Reactive Oxygen Species; Microtubule Associated	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	Lexibulin (CYT-997) 是一种微管蛋白聚集强效抑制剂，可诱导细胞凋亡，并诱导 GC 细胞中的线粒体ROS 生成。它对多种癌细胞的 IC50 值为 10-100n M，在体内外具有高细胞毒性和血管增生阻断作用。
T2511	Plinabulin 普那布林,NPI-2358	Microtubule Associated	Cytoskeletal Signaling
	Plinabulin (NPI-2358) 是一种抗微管蛋白解聚肿瘤细胞的血管破坏剂，选择性地靶向并结合到微管蛋白的秋水仙碱结合位点，从而中断微管动力学的平衡。它对人肿瘤细胞系具有抑制作用，对 HT-29 细胞系的IC50值为 9.8 nM。
T36816	S-trityl-L-Cysteine STLC	Kinesin	Cytoskeletal Signaling
	S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。
T23865	CCT-271850 MPS1-IN-77,MPS1IN77,CCT271850,CCT 271850,MPS1 IN 77	Others	Others
	CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.
T21321	MK-0731	Others	Others
	MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in
T28694	SB-743921 free base SB743921,SB-921,SB921,SB-743921,GSK-743921,GSK-921	Others	Others
	SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).
T25418	Filanesib TFA Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA	Others	Others
	Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during
T73229	Mps1-IN-4	Others	Others
	Mps1-IN-4，一种针对Monopolar spindle 1 (Mps1)的选择性抑制剂，展现出抗增殖特性，适用于癌症领域的研究。
T38710	JH295	Others	Others
	JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
T68743	AZD4877 HCl	Others	Others
	AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur...
T14906	CCT251455	Kinesin	Cytoskeletal Signaling
	CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
T17007	TC-Mps1-12	Kinesin	Cytoskeletal Signaling
	TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
T10373	(R)-Filanesib (R)-ARRY-520	Others	Others
	(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).
T37050	MPS1/TTK Inhibitor MPS1/TTK Inhibitor	Others	Others
	MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells entering anaphase within 15 minutes, indicating MPS1 checkpoint inhibition, when used at a concentration of 100 nM. MPS1/TTK inhibitor (50 and 100 nM) increases the number of missegr...
T71232	Alisertib sodium hydrate	Others	Others
	Alisertib sodium hydrate is a salt of Alisertib --- an inhibitor of Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation.
T72757	TTK inhibitor 3	Others	Others
	TTK inhibitor 3 是一种有效的选择性TTK（一种必需的纺锤体组装检查点酶）抑制剂，其IC50值为 3.0 nM。
T71082	DW532	Others	Others
	DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 values were 4.9 and 5.5 μmol/L, respectively), and suppressed their downstream signaling. DW532 dose-dependently inhibited tubulin polymerization via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. In a panel of human ca...
T73483	RMS-07	Others	Others
	RMS-07 是 Monopolar Spindle Kinase 1 (MPS1/TTK)的共价抑制剂，其 IC50值为 13.1 nM。RMS-07靶向激酶结构域的半胱氨酸。
T73195	EAPB 02303	Others	Others
	EAPB 02303 是一种微管破坏剂和抑制剂。EAPB 02303 诱导有丝分裂停止和纺锤体组装损伤。因此，EAPB 02303 诱导细胞凋亡 (apoptosis) 并表现出抗肿瘤活性。EAPB 02303 在较低浓度下也表现出与紫杉醇的强协同作用。
T61061	JH295 hydrate	Others	Others
	JH295 hydrate 通过 Cys22 烷基化从而抑制细胞Nek2，它是有效的，不可逆和选择性的NIMA 相关激酶 2 (Nek2)抑制剂 (IC50 = 770 nM)。JH295 hydrate 对有丝分裂激酶 Cdk1，Aurora B 或 Plk1 不具有活性，不干扰双极纺锤体组件或纺锤体组件检查点。
T68686	DAP-81	Others	Others
	DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.
T37063	Laulimalide	Others	Others
	Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles. Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety fo...
T68428	ZK-Thiazolidinone	Others	Others
	ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiaz...
T25025	ALB-109564 dihydrochloride	Others	Others
	ALB-109564 dihydrochloride 是长春碱生物碱的半合成衍生物，是一种微管蛋白抑制剂和抗肿瘤药物。它与微管蛋白单体结合并抑制微管的形成，导致有丝分裂纺锤体组装的破坏和肿瘤细胞停滞在细胞周期的G2/M 期。
T70095	Mps1-IN-1 dihydrochloride	Others	Others
	Mps1-IN-1 dihydrochloride 是一种有效的，ATP 竞争性 Mps1激酶抑制剂，IC50为 367 nM。Mps1-IN-1 dihydrochloride 抑制 Mps1有丝分裂激酶活性并沉默纺锤体组装检查点 (SAC) 功能。Mps1-IN-1 dihydrochloride 降低癌细胞和“正常”细胞的活力。
T71556	MK-1496	Others	Others
	MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a n...
T38428	Alisertib sodium MLN 8237 sodium	Others	Others
	Alisertib sodium (MLN 8237) is a potent and specific inhibitor (IC50 = 1.2 nM) of Aurora A kinase, an enzyme involved in cell division. By binding to Aurora A kinase, Alisertib sodium disrupts the formation of the mitotic spindle and causes abnormal cell division. At the molecular level, it acts on the AKT/mTOR/AMPK/p38 pathway, leading to the induction of apoptosis and autophagy in leukemic cells. This compound exhibits significant antitumor activity.
T68273	BNC105P	Others	Others
	BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, deprivi...
T78138	SIC5-6	Others	Others
	SIC5-6为一强效Separase抑制剂，此酶为大型半胱氨酸蛋白酶，关键参与有丝分裂与减数分裂中染色体分离，DNA损伤修复，中心体分离与复制，以及纺锤体稳定与伸长。Separase在众多实体瘤高表达，成为潜在的化疗靶标。
T78125	PVZB1194	Kinesin	Cytoskeletal Signaling
	PVZB1194是一种联苯型激酶Eg5（亦称KIF11）抑制剂，与细胞周期相关，可以通过抑制Eg5的ATP酶活性导致细胞周期阻滞和细胞凋亡，从而显现抗癌潜力。该化合物与α4/α6变抗袋结合，展现ATP竞争性活性。
T62148	NW 1028	Others	Others
	NW 1028 是一种 VCP/p97 的有效抑制剂。NW 1028 能够选择性作用于 p97 的 ND1L 结构域，抑制依赖于 p97 的报告基因的降解。NW 1028 能够良好的结合 ND1L (Kd: 100 nM) 和全长 p97 (Kd: 285 nM)。NW 1028 对细胞有丝分裂纺锤体具有调节作用。
T36199	AZD 1152 (hydrochloride)	Others	Others
	AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5 1.Mortlock, A.A., Foote, K.M., Heron, N.M., et al.Discovery, synthesis, and in vivo activity of a new class of p...

化合物

Cat.No: T3434

Target: Kinesin

Cat.No: T16130

Target: Kinesin

Cat.No: T2689

Synonym: AZ 3146

Target: Kinesin

Cat.No: T2313

Target: Apoptosis, Kinesin

Cat.No: T1839

Target: Kinesin, PLK

Cat.No: T12237

Target: Casein Kinase, Kinesin, MELK, MAPK

Cat.No: T8487

Synonym: BAY 1161909

Target: Kinesin

Cat.No: T14765

Target: Kinesin

Cat.No: T8492

Target: Apoptosis, FGFR

Cat.No: T2241

Synonym: MLN 8237,4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸

Target: Apoptosis, Aurora Kinase, Autophagy

SB-743921 hydrochloride

Cat.No: T2255

Synonym: SB743921 HCl,SB743921

Target: Kinesin, KSP

Cat.No: T9682

Synonym: AZD4877

Target: Apoptosis, Kinesin

Cat.No: T9831

Synonym: Ro-31-7453

Target: Apoptosis, Akt, Microtubule Associated, mTOR

Cat.No: T5699

Target: Apoptosis, Microtubule Associated

Cat.No: T2103

Synonym: 伊匹尼塞,伊斯平斯,CK0238273,SB-715992

Target: Apoptosis, Kinesin, KSP

Cat.No: TQ0318

Synonym: ARRY-520,ARRY 520

Target: KSP

ARRY 520 hydrochloride

Cat.No: TQ0318L

Target: KSP

Cat.No: T2090

Synonym: CYT-997

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated

Cat.No: T2511

Synonym: 普那布林,NPI-2358

Target: Microtubule Associated

S-trityl-L-Cysteine

Cat.No: T36816

Synonym: STLC

Target: Kinesin

Cat.No: T23865

Synonym: MPS1-IN-77,MPS1IN77,CCT271850,CCT 271850,MPS1 IN 77

Target: Others

Cat.No: T21321

Target: Others

SB-743921 free base

Cat.No: T28694

Synonym: SB743921,SB-921,SB921,SB-743921,GSK-743921,GSK-921

Target: Others

Cat.No: T25418

Synonym: Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA

Target: Others

Cat.No: T73229

Target: Others

Cat.No: T38710

Target: Others

Cat.No: T68743

Target: Others

Cat.No: T14906

Target: Kinesin

Cat.No: T17007

Target: Kinesin

Cat.No: T10373

Synonym: (R)-ARRY-520

Target: Others

MPS1/TTK Inhibitor

Cat.No: T37050

Synonym: MPS1/TTK Inhibitor

Target: Others

Alisertib sodium hydrate

Cat.No: T71232

Target: Others

TTK inhibitor 3

Cat.No: T72757

Target: Others

Cat.No: T71082

Target: Others

Cat.No: T73483

Target: Others

Cat.No: T73195

Target: Others

Cat.No: T61061

Target: Others

Cat.No: T68686

Target: Others

Cat.No: T37063

Target: Others

ZK-Thiazolidinone

Cat.No: T68428

Target: Others

ALB-109564 dihydrochloride

Cat.No: T25025

Target: Others

Mps1-IN-1 dihydrochloride

Cat.No: T70095

Target: Others

Cat.No: T71556

Target: Others

Alisertib sodium

Cat.No: T38428

Synonym: MLN 8237 sodium

Target: Others

Cat.No: T68273

Target: Others

Cat.No: T78138

Target: Others

Cat.No: T78125

Target: Kinesin

Cat.No: T62148

Target: Others

AZD 1152 (hydrochloride)

Cat.No: T36199

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN7041	(-)-Epipodophyllotoxin	Apoptosis	Apoptosis
	(-)-Epipodophyllotoxin 是一种从八角莲中分离的癌细胞抗增殖剂，在 HeLa 细胞和 MCF-7 细胞中的GI50值分别为 0.36 和 0.24 μM。它可在体外抑制有丝分裂纺锤体组装。
T1270	Vincristine sulfate Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate,硫酸长春新碱	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Vincristine sulfate (Leurocristine sulfate) 是一种抗肿瘤长春花生物碱。在细胞周期的 S 期不可逆地与微管(Ki: 85 nM) 和纺锤体蛋白结合，并干扰有丝分裂纺锤体的形成。
T0190	Vinorelbine 长春瑞宾,KW-2307 base	Microtubule Associated	Cytoskeletal Signaling
	Vinorelbine (KW-2307 base) 是一种半合成的长春花生物碱。它与微管蛋白结合并阻止有丝分裂纺锤体的形成，导致中期肿瘤细胞生长停滞。
T22455	Vindesine sulfate DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS	Others	Others
	Vindesine sulfate (Desacetyl Vinblastine amide) 是一种长春花生物碱，它是长春碱的合成衍生物，与有丝分裂纺锤体的微管蛋白结合，导致微管结晶和有丝分裂停滞或细胞死亡。
T1121	Podofilox 鬼臼毒素,Podophyllotoxin,(+)-Shikonin	Microtubule Associated; Topoisomerase	Cytoskeletal Signaling; DNA Damage/DNA Repair
	Podofilox ((+)-Shikonin) 是从八角莲中分离的一种木脂素，是微管组装和 DNA 拓扑异构酶 II 抑制剂。它对皮肤和粘膜有很强的刺激性，具有角质溶解作用，可用于治疗疣和角化病，具有潜在的抗肿瘤特性。
T32055	Hemiasterlin NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation.

天然产物

(-)-Epipodophyllotoxin

Cat.No: TN7041

Target: Apoptosis

Vincristine sulfate

Cat.No: T1270

Synonym: Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate,硫酸长春新碱

Target: Apoptosis, Microtubule Associated

Cat.No: T0190

Synonym: 长春瑞宾,KW-2307 base

Target: Microtubule Associated

Vindesine sulfate

Cat.No: T22455

Synonym: DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS

Target: Others

Cat.No: T1121

Synonym: 鬼臼毒素,Podophyllotoxin,(+)-Shikonin

Target: Microtubule Associated, Topoisomerase

Cat.No: T32055

Synonym: NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin

Target: Others, ADC Cytotoxin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01639	MAPK1IP1L Protein, Human, Recombinant (hFc) Mitogen-activated protein kinase 1-interacting protein 1-lik...	Human	HEK293 Cells
	N/A. MAPK1IP1L Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q8NDC0.
TMPY-02714	PRC1 Protein, Human, Recombinant (His) ASE1,protein regulator of cytokinesis 1	Human	Baculovirus Insect Cells
	PRC1 (protein regulator of cytokinesis 1) is a key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. It is essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. PRC1 is required for KIF14 localization to the central spindle and midbody. It is also required to recruit PLK1 to the spindle. PRC1 stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. It is a homodi...
TMPH-02304	Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO) Vasohibin-2,VASH2,Vasohibin-like protein,Tubulinyl-Tyr carbo...	Human	E. coli
	Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. Vasohibin-2/VASH2 Protein, Human,...
TMPH-01704	RAE1 Protein, Human, Recombinant (GST) Rae1 protein homolog,mRNA-associated protein mrnp 41,mRNA ex...	Human	E. coli
	Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. RAE1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.0 kDa and the accession number is P78406.
TMPY-02238	MAD2L1 Protein, Human, Recombinant (His) MAD2 mitotic arrest deficient-like 1 (yeast),HSMAD2,MAD2	Human	E. coli
	Mitotic spindle assembly checkpoint protein MAD2A, also known as HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, and MAD2, is a nucleus and cytoplasm protein that belongs to the MAD2 family. MAD2L1 is a component of the spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle atta...
TMPH-02327	ZW10 interactor/ZWINT Protein, Human, Recombinant (GST) ZW10-interacting protein 1,ZW10 interactor,ZWINT	Human	E. coli
	Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
TMPH-01253	DCTN3 Protein, Human, Recombinant (His & SUMO) DCTN22,Dynactin complex subunit 22 kDa subunit (p22),Dynacti...	Human	E. coli
	Together with dynein may be involved in spindle assembly and cytokinesis. DCTN3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.3 kDa and the accession number is O75935.
TMPJ-00580	ZWINT Protein, Human, Recombinant (His) ZWINT,ZW10 Interactor,Zwint-1,ZW10-Interacting Protein 1	Human	E. coli
	ZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.
TMPH-01081	CHMP7 Protein, Human, Recombinant (His) Charged multivesicular body protein 7,Chromatin-modifying pr...	Human	E. coli
	ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. CHMP7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 56.9 kDa and the accession number is Q8WUX9.
TMPY-03865	EB3 Protein, Human, Recombinant (His) microtubule-associated protein, RP/EB family, member 3,EB3,R...	Human	E. coli
	MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3, also known as EB3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. MAPRE3 is a member of the RP/EB family. It localizes to the cytoplasmic microtubule network and binds APCL. MAPRE3 regulates the dynamics of the microtubule cytoskeleton and promotes microtubule growth. It may be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. MAPRE3 may also play a role i...
TMPY-03596	JTB Protein, Human, Recombinant (mFc) PAR,hJT,jumping translocation breakpoint,JTB,HSPC222,HJTB	Human	HEK293 Cells
	Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal...
TMPJ-00972	CDKN1B Protein, Human, Recombinant (His) KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,Cyclin-Dep...	Human	E. coli
	Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ...
TMPJ-01013	VCP Protein, Human, Recombinant (His) TER ATPase,Transitional Endoplasmic Reticulum ATPase,15S Mg(...	Human	E. coli
	Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin...
TMPH-01642	MELK Protein, Human, Recombinant (His & Myc) Protein kinase Eg3,Tyrosine-protein kinase MELK,Protein kina...	Human	E. coli
	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. ...
TMPH-01621	BRCC3 Protein, Human, Recombinant (His & SUMO) BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/BRCA2-containing complex su...	Human	E. coli
	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta...
TMPY-02228	p53 Protein, Cynomolgus, Recombinant tumor protein p53,p53,TP53	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...
TMPH-01270	TRAIP Protein, Human, Recombinant (His) E3 ubiquitin-protein ligase TRAIP,TRAF-interacting protein,T...	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,...	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...

重组蛋白

MAPK1IP1L Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01639

Species: Human

Expression System: HEK293 Cells

PRC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02714

Species: Human

Expression System: Baculovirus Insect Cells

Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02304

Species: Human

Expression System: E. coli

RAE1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01704

Species: Human

Expression System: E. coli

MAD2L1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02238

Species: Human

Expression System: E. coli

ZW10 interactor/ZWINT Protein, Human, Recombinant (GST)

Cat.No: TMPH-02327

Species: Human

Expression System: E. coli

DCTN3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01253

Species: Human

Expression System: E. coli

ZWINT Protein, Human, Recombinant (His)

Cat.No: TMPJ-00580

Species: Human

Expression System: E. coli

CHMP7 Protein, Human, Recombinant (His)

Cat.No: TMPH-01081

Species: Human

Expression System: E. coli

EB3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03865

Species: Human

Expression System: E. coli

JTB Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03596

Species: Human

Expression System: HEK293 Cells

CDKN1B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00972

Species: Human

Expression System: E. coli

VCP Protein, Human, Recombinant (His)

Cat.No: TMPJ-01013

Species: Human

Expression System: E. coli

MELK Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01642

Species: Human

Expression System: E. coli

BRCC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01621

Species: Human

Expression System: E. coli

p53 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-02228

Species: Cynomolgus

Expression System: E. coli

TRAIP Protein, Human, Recombinant (His)

Cat.No: TMPH-01270

Species: Human

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

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