26
1
1734
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12922 |
Sirtuin modulator 1
SRT3025 Hydrochloride |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Sirtuin modulator 1 (SRT3025 Hydrochloride) 是 SIRT1 的调节剂,EC1.5 < 1 μM。 | |||
T79903 |
Sirtuin-1 inhibitor 1
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Sirtuin-1 inhibitor 1 是一种针对去乙酰化酶-1(Sirtuin-1)的抑制剂,可用于研究机体的衰老和细胞的死亡。 | |||
T12918 |
SIRT-IN-1
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT-IN-1 是一种有效SIRT1/2/3抑制剂,IC50分别为 15,10,33 μM。 | |||
T5618 |
AK-1
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
AK-1是一种特异性有效和细胞可渗透的SIRT2抑制剂,其IC50值为 12.5 μM。它可防止阿尔茨海默病模型中的海马神经退行性变并诱导结肠癌细胞中的细胞周期停滞。 | |||
T9648 |
SIRT1-IN-1
|
Antiviral; Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation |
SIRT1-IN-1 是一种选择性的 SIRT1 抑制剂,IC50 为 205 nM。 SIRT1-IN-1 是一种具有抗病毒活性的巨细胞病毒 (CMV) 抑制剂。 | |||
T1919 |
Tenovin-1
Tenovin 1 |
Mdm2; Dehydrogenase; Sirtuin; p53; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Tenovin-1 抑制 SirT1 和 SirT2 的蛋白质去乙酰化活性,并防止 MDM2 介导的 p53 降解,这涉及泛素化。它具有癌症的研究潜力。 | |||
T4328 |
OSS_128167
SIRT6-IN-1 |
HBV; Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂,对 SIRT6,SIRT1 和 SIRT2 的 IC50分别为 89 μM,1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性,可抑制 HBV 的转录和复制。 | |||
T6671 |
Sirtinol
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 |
Apoptosis; Sirtuin; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Sirtinol 是一种 sirtuin 的抑制剂,对 ySir2,hSIRT2 和 hSIRT2 的IC50值分别为 48 μM,57.7 μM 和 131 μM。 | |||
T9320 |
YK-3-237
B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) 是 SIRT1 激活剂,靶向突变体 p53。它抑制三阴性乳腺癌细胞的增殖。 | |||
T5096 |
SRT 1720
N-[2-[3-(1-哌嗪基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-喹喔啉甲酰胺 |
Sirtuin; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
SRT 1720 是人 SIRT1 的选择性激活剂 ,EC1.5为 0.16 μM,对 SIRT2 和 SIRT3 的效力要低 230 倍以上。 | |||
T8346 |
SRT 1460
3,4,5-三甲氧基-N-(2-(3-(哌嗪-1-基甲基)咪唑并[2,1-B]噻唑-6-基)苯基)苯甲酰胺,SRT1460 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SRT 1460 是一种有效的SIRT1激动剂,其EC1.5值为 2.9 μM。 | |||
T7058 |
Selisistat S-enantiomer
EX-527 S-enantiomer,(1S)-6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺,EX-527 (S-enantiomer) |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Selisistat S-enantiomer (EX-527 S-enantiomer) 是一种选择性的SIRT1抑制剂,IC50值为 98 nM。 | |||
T22595 |
B2
Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline,奥司他韦杂质B(2-叠氮杂合物) |
Others; Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
B2 (Linazolamide intermediate B impurity 2) 促进亨廷顿病和帕金森病细胞模型中的包涵体形成。 | |||
T77653 |
Z26395438
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Z26395438 是 一种 IC50 值为 1.6 μM 的 Sirtuin-1 的抑制剂。 | |||
T12920 |
Sirt2-IN-1
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Sirt2-IN-1 是 sirtuin 2 的抑制剂 (IC50 = 163 nM)。 | |||
T12921 |
SIRT5 inhibitor 1
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT5 inhibitor 1是一种高效且具有选择性的人类 Sirtuin 5脱酰基酶抑制剂(IC50:0.11μM)。SIRT5 inhibitor 1与衰老相关疾病有关。 | |||
T21679 |
4'-bromo-Resveratrol
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
4'-Bromo-resveratrol 是Sirtuin-1和Sirtuin-3的双重抑制剂。它通过线粒体代谢重编程,使黑色素瘤细胞的生长受到抑制。它通过代谢重编程、影响细胞周期以及细胞凋亡的信号传导,使其在黑色素瘤细胞中发挥抗增殖作用。 | |||
T16932 |
SRT 2183
|
Apoptosis; Sirtuin | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
SRT 2183 是一种选择性Sirtuin-1激活剂,其EC1.5值为 0.36 μM。它诱导生长停滞和凋亡,同时伴随 STAT3 和 NF-κB 去乙酰化,并降低 c-Myc 蛋白水平。 | |||
Fr13587 |
7-Chloro-4-(piperazin-1-yl)quinoline
|
Others | Others |
7-Chloro-4-(piperazin-1-yl)quinolone 结构是药物化学中的重要支架,它单独或与其他活性药效团混合显示出多种药理特性。7-Chloro-4-(piperazin-1-yl)quinolone 是有效的sirtuin 抑制剂,并且抑制 5-羟色胺的摄取,IC50值为 50 μM。7-Chloro-4-(piperazin-1-yl)quinolone 对恶性疟原虫 D10 和 K1 菌株表现出抗疟疾活性,IC50分别为 1.18 μM 和 0.97 μM。 | |||
T78857 |
SIRT5 inhibitor 9
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT5 inhibitor9 (compound 14) 作为SIRT5的一种竞争性抑制剂,其IC50为4.07 μM,显示出潜在的抗癌效应。 | |||
T80813 |
WAY-354574
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
WAY-354574为针对Sirtuin(脱乙酰酶)的活性化合物,适用于亨廷顿病(HD)研究。 | |||
T78856 |
SIRT5 inhibitor 8
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT5 inhibitor8 (compound 10) 作为竞争性去乙酰化酶SIRT5抑制剂,显示出IC50值为5.38 μM的抑制活性,并可能具有抗癌潜力。 | |||
T18641 |
SirReal1-O-propargyl
PROTAC Sirt2-binding moiety 1 |
Others | Others |
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1]. | |||
T74672 |
Sirtuin modulator 5
|
Others | Others |
Sirtuinmodulator 5 是一种sirtuin 调节剂。Sirtuinmodulator 5 可以激活SIRTl,DC50值 <50 μM。Sirtuinmodulator 5 可用于增加细胞的寿命并用于研究多种疾病,包括例如与衰老或压力、糖尿病、肥胖症、神经退行性疾病、心血管疾病、凝血障碍、 炎症、癌症和/或潮红以及将受益于线粒体活性增加的疾病或病症。 | |||
T36521 |
Alaproclate (hydrochloride)
|
Others | Others |
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio... | |||
T72188 |
Nicotinamide Hydrochloride
Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride |
Others | Others |
Nicotinamide Hydrochloride 是维生素 B3 或烟酸的一种形式,可抑制SIRT2的体外活性,其EC50值为 2 μM。 Nicotinamide Hydrochloride 可抑制 90% 的黑色素瘤细胞数量,并增加细胞内 NAD+、ATP、ROS 水平。Nicotinamide Hydrochloride 抑制黑色素瘤小鼠的肿瘤生长并提高生存率,可用于黑色素瘤等皮肤癌相关的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S0800 |
Demethyleneberberine
|
P450; NOS; NF-κB; HIF; AMPK | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
Demethyleneberberine 是从黄连中提取的一种天然产物,是线粒体靶向抗氧化剂。它也可作为AMPK 激活剂,用于非酒精性脂肪性肝病的研究。它通过抑制NF-κB 通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01869 |
SIRT1 Protein, Human, Recombinant (His)
SIR2L1,sirtuin 1 |
Human | E. coli |
SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. It deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. SIRT1 also deacetylates TAF1B and there... | |||
TMPY-02893 |
NT5C3A/NT5C3 Protein, Human, Recombinant
P5N1,P5N-1,hUMP1,NT5C3,cN-III,PSN... |
Human | E. coli |
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but... | |||
TMPY-04451 |
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
AMPK, AMPK(α1, β1, γ1) |
Human | Baculovirus Insect Cells |
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&Q13131-1. | |||
TMPY-03878 |
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
Integrin alpha V β6,ITGAV & ITGB6,integrin, alpha 5 (fibrone... |
Human | HEK293 Cells |
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1. | |||
TMPY-02501 |
CD3D & CD3E Heterodimer Protein, Human, Recombinant
CD3d molecule, δ (CD3-TCR complex),CD3-δ,CD3d molecule, delt... |
Human | HEK293 Cells |
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1. | |||
TMPY-02030 |
CD82 Protein, Human, Recombinant (His)
CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,T... |
Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud... | |||
TMPY-01894 |
SIGIRR Protein, Human, Recombinant (His)
TIR8,single immunoglobulin and toll-interleukin 1 r... |
Human | HEK293 Cells |
SIGIRR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14 kDa and the accession number is Q6IA17-1. | |||
TMPY-01247 |
FLT3 Protein, Human, Recombinant (T227M, His)
FLK2,FLK-2,CD135,STK1,fms-related tyrosine... |
Human | HEK293 Cells |
FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1. | |||
TMPY-02779 |
Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His)
thyroid peroxidase,MSA,TPX,TDH2A |
Human | Baculovirus Insect Cells |
Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. It used to be taken as the formerly so-called `microsomal antigen` several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two i... | |||
TMPY-03290 |
HGF Protein, Mouse, Recombinant
hepatocyte growth factor (hepapoietin A,NK1,scatter... |
Mouse | HEK293 Cells |
HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1. | |||
TMPY-04970 |
TIGIT Protein, Human, Recombinant (hFc)
WUCAM,VSTM3,VSIG9,T cell immunoreceptor with Ig and ITIM dom... |
Human | HEK293 Cells |
TIGIT Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.2 kDa and the accession number is Q495A1-1. | |||
TMPY-01147 |
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)
RSPO,CRISTIN3,R-spondin 1 |
Human | HEK293 Cells |
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is Q2MKA7-1. | |||
TMPY-04346 |
PD-L2 Protein, Human, Recombinant (His)
PD-L2,B7-DC,CD273,Btdc,PDCD1L2,B7DC,PDL2,programmed... |
Human | HEK293 Cells |
PD-L2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1. | |||
TMPY-00947 |
VCAM-1 Protein, Human, Recombinant (hFc)
INCAM-100,CD106,VCAM-1,vascular c... |
Human | HEK293 Cells |
VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1. | |||
TMPY-01949 |
CD19 Protein, Human, Recombinant (His)
CD19 molecule,B4,CVID3 |
Human | HEK293 Cells |
CD19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is P15391-1. | |||
TMPY-04165 |
FGFR3 Protein, Human, Recombinant (His)
JTK4,CEK2,fibroblast growth factor receptor 3,HSFGFR3EX,CD33... |
Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.6 kDa and the accession number is P22607-1. | |||
TMPY-00820 |
IgG1 Fc Protein, Human, Recombinant (C103S)
Ighg1,IgG1 Fc |
Human | HEK293 Cells |
IgG1 Fc Protein, Human, Recombinant (C103S) is expressed in HEK293 mammalian cells. The predicted molecular weight is 26 kDa and the accession number is P01857-1. | |||
TMPY-01146 |
Insulin Receptor Protein, Human, Recombinant (long isoform, His)
HHF5,CD220,insulin receptor |
Human | HEK293 Cells |
Insulin Receptor Protein, Human, Recombinant (long isoform, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 107 kDa and the accession number is P06213-1. | |||
TMPY-04348 |
CTLA-4 Protein, Human, Recombinant (His)
ALPS5,CD152,GRD4,cytotoxic T-lymphocyte-associated ... |
Human | HEK293 Cells |
CTLA-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1. | |||
TMPY-02813 |
ErbB4 Protein, Human, Rhesus, Recombinant (His)
erb-b2 receptor tyrosine kinase 4 |
Human,Rhesus | HEK293 Cells |
ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1. | |||
TMPY-05220 |
TSLP Protein, Human, Recombinant (R127A & R130S, His)
thymic stromal lymphopoietin |
Human | HEK293 Cells |
TSLP Protein, Human, Recombinant (R127A & R130S, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is Q969D9-1. | |||
TMPY-01827 |
CD30/TNFRSF8 Protein, Human, Recombinant (His)
D1S166E,tumor necrosis factor receptor sup... |
Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P28908-1. | |||
TMPY-00853 |
IL-1RA Protein, Human, Recombinant
DIRA,IL1RA,interleukin 1 receptor antagoni... |
Human | E. coli |
IL-1RA Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is P18510-1. | |||
TMPY-01850 |
CEACAM3 Protein, Human, Recombinant (His)
W282,W264,CEA,CD66D,CGM1,MGC11987... |
Human | HEK293 Cells |
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexp... | |||
TMPY-02245 |
SNAP-25 Protein, Human, Recombinant (His)
synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ |
Human | E. coli |
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp... | |||
TMPY-00203 |
LOXL2 Protein, Mouse, Recombinant (His)
1110004B06Rik,4930526G1<... |
Mouse | HEK293 Cells |
Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme act... | |||
TMPY-01281 |
ACVR2B Protein, Mouse, Recombinant (His)
ActRIIB,activin A receptor, type IIB,4930516B21... |
Mouse | HEK293 Cells |
ACVR2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P27040-1. | |||
TMPY-01851 |
CD73 Protein, Human, Recombinant (His)
eN,NT5,E5NT,NT,5'-nucleotidase, ecto (CD73),NTE,CALJA,eNT,CD... |
Human | HEK293 Cells |
CD73 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is P21589-1. | |||
TMPY-02525 |
RGMA Protein, Human, Recombinant (His)
repulsive guidance molecule family member a,RGM |
Human | HEK293 Cells |
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that form... | |||
TMPY-03967 |
BTN3A3 Protein, Human, Recombinant (His)
BTF3,BTN3.3,butyrophilin subfamily 3 member A3,BTN3A3 |
Human | HEK293 Cells |
BTN3A3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is O00478-1. | |||
TMPY-05208 |
PD-L1 Protein, Human, Recombinant
CD274 molecule,PDCD1L1,PD-L1,PDL<... |
Human | HEK293 Cells |
PD-L1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is Q9NZQ7-1. | |||
TMPY-00978 |
Progranulin Protein, Human, Recombinant (His)
PGRN,PCDGF,CLN11,Granulin,GP88,GEP,Granuli... |
Human | HEK293 Cells |
Progranulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.2 kDa and the accession number is P28799-1. | |||
TMPY-03407 |
NQO1 Protein, Human, Recombinant (His)
NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1... |
Human | E. coli |
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex... | |||
TMPY-01258 |
IL-13RA1 Protein, Human, Recombinant (His)
NR4,interleukin 13 receptor, alpha 1,CD2 |
Human | HEK293 Cells |
IL-13RA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1. | |||
TMPY-03531 |
PSGL-1/CD162 Protein, Human, Recombinant (His)
selectin P ligand,PSGL-1,PSGL1,CD1 |
Human | HEK293 Cells |
PSGL-1/CD162 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.5 kDa and the accession number is Q14242-1. | |||
TMPY-01883 |
EPOR Protein, Human, Recombinant (His)
erythropoietin receptor,EPO-R |
Human | HEK293 Cells |
EPOR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1. | |||
TMPY-01862 |
IL-4 Protein, Human, Recombinant
Interleukin-4,IL-4,BCGF1,白细胞介素,interleukin 4,BSF |
Human | E. coli |
IL-4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.1 kDa and the accession number is P05112-1. | |||
TMPY-06418 |
R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)
R-spondin 2,CRISTIN2 |
Human | HEK293 Cells |
R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.01 kDa and the accession number is Q6UXX9-1. | |||
TMPY-04333 |
LRRC15 Protein, Human, Recombinant (hFc)
leucine rich repeat containing 15,LIB |
Human | HEK293 Cells |
LRRC15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.5 kDa and the accession number is Q8TF66-1. | |||
TMPY-02033 |
CD44 Protein, Human, Recombinant (His)
CD44 molecule (Indian blood group),IN,MC56,HUTCH-I,MIC4,CDW4... |
Human | HEK293 Cells |
CD44 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is P16070-1. | |||
TMPY-04104 |
LIF Protein, Human, Recombinant
CDF,DIA,白血病抑制因子,MLPLI,Leukemia Inhibitory Factor,HILDA |
Human | HEK293 Cells |
LIF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.7 kDa and the accession number is P15018-1. | |||
TMPY-04939 |
LAG-3 Protein, Human, Recombinant
LAG-3,lymphocyte-activation gene 3,CD223 |
Human | HEK293 Cells |
LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1. | |||
TMPY-00861 |
IL-33 Protein, Human, Recombinant
IL1F11,C9orf26,NFEHEV,NF-HEV,DVS2... |
Human | E. coli |
IL-33 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is O95760-1. | |||
TMPY-06873 |
FLT3 Ligand Protein, Human, Recombinant
FLT3LG,fms related tyrosine kinase 3 ligand,FLT3L,FL |
Human | E. coli |
FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1. | |||
TMPY-01185 |
DR5/TRAIL R2 Protein, Human, Recombinant (His)
KILLER,TRICK2A,TRICK2,DR5,TRICKB,tumor necrosis factor recep... |
Human | HEK293 Cells |
DR5/TRAIL R2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O14763-1. | |||
TMPY-01938 |
CD98 Protein, Human, Recombinant (His)
4T2HC,4F2,CD98HC,NACAE,MDU1,4F2HC,CD98,solute carri... |
Human | HEK293 Cells |
CD98 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P08195-1. | |||
TMPY-01137 |
HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)
erb-b2 receptor tyrosine kinase 2,NEU,ENVW,HERV-7q,HERV7Q,HE... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1. | |||
TMPY-04826 |
LILRB5/CD85c Protein, Human, Recombinant (His)
leukocyte immunoglobulin like receptor B5,LIR8,LIR-8,CD85C |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weig... | |||
TMPY-01744 |
ACVR2A Protein, Human, Recombinant (His)
activin A receptor, type IIA,ACVR2,ACTRII |
Human | HEK293 Cells |
ACVR2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P27037-1. | |||
TMPK-00887 |
KIR3DL2 Protein, Human, Recombinant (His & Avi)
KIR3DL2,p140,NKAT4,NKAT4A,NKAT4B,CL-5,CD15... |
Human | HEK293 Cells |
KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linked homodimer. Each chain is composed of three immunoglobulin-like domains and a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. KIR3DL2 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The pred... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T69395 |
Nicotinamide-d4
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Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl... |