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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14004 |
1A-116
|
Rho | Cell Cycle/Checkpoint |
1A-116 是 Rac1的抑制剂,对几种类型的癌症具有抗肿瘤和抗转移作用,如乳腺癌。 | |||
T9356 |
(E/Z)-GO289
|
Casein Kinase | Metabolism; Stem Cells |
(E/Z)-GO289 是一种选择性酪蛋白激酶 2 抑制剂,IC50值为 7 nM。它可显着延长昼夜节律周期,表现出与细胞时钟功能相关的癌细胞生长的细胞类型依赖性抑制。 | |||
T32401 |
KL044
KL 044,KL-044 |
Others | Others |
KL044 是一种隐花色素 1(CRY1) 激活剂,可延长昼夜节律并抑制 PER2 的活性。 KL044 通过抑制cAMP/PKA/CREB 通路来抑制黑色素生成。 | |||
T9608 |
KL201
|
Others | Others |
KL201 是一种昼夜节律调制器,是 CRY1选择性的 稳定剂, 对 CRY2 没有稳定作用。KL201 延长了细胞和组织中的昼夜节律周期。 | |||
T7219 |
Flecainide acetate
Flecainide (acetate),氟卡胺,R-818,醋酸洗必太 |
Sodium Channel | Membrane transporter/Ion channel |
Flecainide acetate (R-818) 是位于心脏的 Nav1.5钠离子通道的阻断剂,具有抗心律失常的作用。 | |||
T24083 |
Gallopamil, (-)-
(-)-Methoxyverapamil,(S)-Gallopamil,(-)-Gallopamil,(-)-D 600 |
Others | Others |
Gallopamil, (-)- is an L-type calcium channel blocker. It is used in the treatment of abnormal heart rhythms. | |||
T24082 |
Gallopamil HCl, (-)-
L-Gallopamil hydrochloride,(S)-Gallopamil hydrochloride,(-)-Gallopamil hydrochloride |
Others | Others |
Gallopamil HCl, (-)- is an L-type calcium channel blocker. It is used in the treatment of abnormal heart rhythms. | |||
T27430 |
GR 196429
GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429 |
Others | Others |
GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice. | |||
T70812 |
PF-05236216 hydrochloride
|
Others | Others |
PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhythms in mice. | |||
T80849 |
VU661
|
Others | Others |
VU661, 一种吩嗪甲酰胺类化合物,作为昼夜节律调节剂能促使昼夜节律周期延长,该小分子具备氧化还原活性。 | |||
T63375 |
FT709
|
Others | Others |
FT709 是选择性的USP9X 有效抑制剂 (IC50: 82 nM)。其中USP9X 与中心体功能、EGF 受体降解、有丝分裂期间的染色体排列、化学致敏和昼夜节律有关。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7938 |
Quinidine
奎尼丁,奎宁树 |
Parasite | Microbiology/Virology |
Quinidine 是一种抗心律失常剂,也是 K+通道的有效阻断剂,其 IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂,也可研究疟疾。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00286 |
Neuropeptide Y Protein, Human, Recombinant (hFc)
PYY4,neuropeptide Y |
Human | HEK293 Cells |
NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. NPY is a neuromodulator that is widely expressed throughout the central nervous system (CNS) and is consecrated with classic neurotransmitters including GABA and glutamate. NPY/Agouti-related protein (AgRP) ne... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0469 |
Quinidine-d3
|
||
Quinidine-d3 是 Quinidine 的氘代化合物。Quinidine 的 CAS 号为 56-54-2。Quinidine 是一种抗心律失常剂,也是 K+通道的有效阻断剂,其IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂,也可研究疟疾。 | |||
TMID-0183 |
Flecainide-d4 Acetate
|
||
Flecainide-d4 Acetate 是 Flecainide Acetate 的氘代化合物。Flecainide Acetate 的 CAS 号为 54143-56-5。Flecainide acetate 是位于心脏的 Nav1.5钠离子通道的阻断剂,具有抗心律失常的作用。 |