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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T37314 JKE-1674

GPX oxidation-reduction
JKE-1674 是口服有效的谷胱甘肽过氧化物酶 4 (GPX4)抑制剂,是ML-210的活性代谢物,ML-210也是GPX4抑制剂。它可转换成丁腈氧化物 JKE-1777。它用与 ML-210 相同的方式杀死 LOX-IMVI 细胞,并被ferroptosis 抑制剂完全挽救。
T13705 GLPG2451

Cysteine Protease Proteases/Proteasome
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM).
T68547 SNJ-1945

Others Others
SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin a...
T35874 CC260

Others Others
CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1]. CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosph...

化合物

JKE-1674
Cat.No: T37314
Synonym:
Target: GPX
GLPG2451
Cat.No: T13705
Synonym:
Target: Cysteine Protease
SNJ-1945
Cat.No: T68547
Synonym:
Target: Others
CC260
Cat.No: T35874
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T3893 Forsythoside B

连翘酯苷 B,连翘脂苷B

TNF; NF-κB Apoptosis; NF-κB
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。

天然产物

Forsythoside B
Cat.No: T3893
Synonym: 连翘酯苷 B,连翘脂苷B
Target: TNF, NF-κB
TargetMol Loading
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