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Search Results for " reporter "

Targets Recommended: Others RAR/RXR

107

抑制剂 & 化合物

7

天然产物

7

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T23383	SR11237 SR 11237	Others; RAR/RXR	Metabolism; Others
	SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
T22101	ML-031	S1P Receptor	GPCR/G Protein
	ML-031 是鞘氨醇 1-磷酸受体 2 (S1PR2)的选择性激动剂，其IC50=1.0 μM，EC50=1.03 μM。它可用于癌症疾病的研究。
T22818	GSK9027 GR agonist 23a,GSK 9027,GSK-9027	Glucocorticoid Receptor	Endocrinology/Hormones
	GSK9027 (GR agonist 23a) 是一种非甾体糖皮质激素受体 (GR) 激动剂。GSK9027 (GR agonist 23a) 在2×GRE报告基因上对比地塞米松的活性属于部分激动剂，活性较地塞米松活性较弱。
T14038L	4-Azido-L-phenylalanine hydrochloride p-Azido-L-phenylalanine hydrochloride,p-Azidophenylalanine hydrochloride	Others	Others
	4-Azido-L-phenylalanine hydrochloride (p-Azido-L-phenylalanine hydrochloride) 是非天然氨基酸，可有效振动报道蛋白质环境。
T4043	ETC-159 ETC159,ETC-1922159,ETC 159	Wnt/beta-catenin; Porcupine	Cytoskeletal Signaling; Stem Cells
	ETC-159 (ETC-1922159) 是一种具有口服活性的，有效 PORCN 抑制剂。抑制β-catenin 报告基因活性的 IC50值为2.9 nM。
T15677	KY1220	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KY1220 通过靶向 Wnt/β-连环蛋白通路，使 β-连环蛋白和 Ras 不稳定。它在 HEK293 报告细胞中的 IC50 为 2.1 μM。
T5636	Adavivint Adavivint (SM04690)	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Adavivint (SM04690) 是选择性的典型的Wnt 信号通路抑制剂，在 SW480 细胞中，用高通量 TCF/LEF 报告基因实验，测得EC50=19.5 nM。
T4361	CBL0137 hydrochloride CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride	Others; NF-κB; p53	Apoptosis; NF-κB; Others
	CBL0137 hydrochloride (Curaxin-137 hydrochloride) 是一种组蛋白分子伴侣FACT 的抑制剂，也可激活p53并抑制NF-κB，对于它们的EC50值分别为 0.37 和 0.47 μM。
T4339	YU238259	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	YU238259 是一种新型的同源依赖性 DNA 修复 (HDR) 抑制剂，在基于细胞的 GFP 报告基因检测中不抑制非同源末端连接 (NHEJ)，可研究癌症。
T19850	Semaglutide 索玛鲁肽,司美格鲁肽,索马鲁肽	Glucagon Receptor	GPCR/G Protein
	Semaglutide 是人胰高血糖素样肽-1受体激动剂，是一种人胰高血糖素样肽-1 的长效类似物。它有用于 2 型糖尿病研究的潜力。
T4684	ML241 hydrochloride	p97	Ubiquitination
	ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂，IC50值为 100 nM。
T8752	BAR 501 impurity	GPCR19	GPCR/G Protein
	BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。
T77725	YAP-TEAD-IN-3 IAG933	YAP	Stem Cells
	YAP-TEAD-IN-3 是 YAP/TAZ-TEAD 相互作用的抑制剂，对于 Avi-人 TEAD4217-434 的 IC50 为 9 nM。 YAP-TEAD-IN-3 抑制 YAP 报告基因表达 (IC50 = 0.048 μM) 和 NCI-H2052 细胞增殖 (IC50 = 0.048 μM)。
T36527	IL-4-inhibitor-1	IL Receptor	Immunology/Inflammation
	IL-4-inhibitor-1 是 IL-4 的抑制剂 (EC50 = 1.81 µM)。
T37587	ML 209	ROR	Metabolism
	ML-209 是一种视黄酸相关的孤儿受体 RORγ 拮抗剂 (IC50= 1.1 μM)。ML-209 抑制 HEK293t 细胞中 RORγt 转录活性(IC50= 300 nM)。ML-209 不抑制细胞中 RORα。ML-209 对鼠 Th17 细胞分化具有选择性抑制，而不影响幼稚 CD4+ T 细胞分化为 Th1 和调节性 T 细胞。
T4687	Ro5-3335 CBFβ-Runx1 inhibitor II,Ro 5-3335	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ro5-3335 (CBFβ-Runx1 inhibitor II) 是苯二氮化合物，是RUNX1-CBFβ 相互作用抑制剂，可抑制 RUNX1/CBFB 依赖性反式激活，能作为核心结合因子 (CBF) 白血病抑制剂。
T36587	APTS 8-Aminopyrene-1,3,6-trisulfonic acid trisodium	Others	Others
	8-Aminopyrene-1,3,6-trisulfonic Acid sodium salt 是一种阴离子荧光染料，用作葡萄糖传感和检测其他糖类的报告分子。激发/发射光谱为 425/503 nm。它可以在溶液中使用，也可以通过还原胺化连接醛官能化单体来固定，而不会显著改变荧光强度。
T13067	TAK-828F	ROR	Metabolism
	TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM).
T38238	2'-Deoxy-2'-fluorocytidine	Nucleoside Antimetabolite/Analog; Influenza Virus	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	2'-Deoxy-2'-fluorocytidine 是一种核苷类似物，可有效抑制刚果出血热病毒的复制。2'-Deoxy-2'-fluorocytidine 与 T705 的协同作用会增强对CCHFV 复制的抵抗效力。
T23970	DDD00015314 DDD-00015314,DDD 00015314	Others	Others
	DDD00015314 is the GUS reporter activity activator that acts by specifically increasing stumpy reporter gene expression.
T71424	VT-102 free base	Others	Others
	VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T68934	VT101 free base	Others	Others
	VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T10403	Atorvastatin ethyl ester	Others	Others
	Atorvastatin ethyl ester, a derivative of Atorvastatin, exhibits potent inhibition of 9-cis-RA-induced Gal4 reporter activity.
T13562	Atorvastatin methyl ester	Others	Others
	Atorvastatin methyl ester is a derivative of Atorvastatin. It inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin.
TD0086	ROX Reference Dye
	ROX Reference Dye was designed to standardize fluorescent reporter gene signals in real-time quantitative PCR or RT-PCR
T29347	2-Ethynyl Adenosine 2-Ethynyl-Ade,2 Ethynyl Adenosine,2-Ethynyl-Adenosine	Others	Others
	2-Ethynyl Adenosine is an Adenosine derivative that is used to capture novel polyadenylated transcription and non-radiochemical reporter molecules of the protein AMPylation.
T39181	Cyanine 3 Tyramide Cyanine 3 Tyramide,Tyramide-Cy3
	Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition for signal amplification in immunoassays and in situ nucleic acid hybridization.
T12916	Silvestrol aglycone	Others	Others
	Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity.
T10374	ARS-1323-alkyne	Ras	GPCR/G Protein; MAPK
	ARS-1323-alkyne 是switch-II pocket (S-IIP)抑制剂，能够特异性报告活体细胞中 KRASG12C 核苷酸的状态。
T37833	CAY10767	Others	Others
	CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50= 37 nM in a reporter assay).1It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ.
T40400	Enhanced Green Fluorescent Protein (EGFP) (200-208)
	Enhanced Green Fluorescent Protein (EGFP) (200-208) is a reporter protein obtained from Aequorea Victoria jellyfish. EGFP is widely used as a marker gene product due to its strong fluorescence properties, making it easily detectable.
T38902	Cyanine 5 Tyramide Tyramide-Cy5
	Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in situ hybridization of nucleic acids.
T37351	Desmethyl Bosentan	Others	Others
	Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan .1Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay. 1.van Giersbergen, P.L.M., Gnerre, C., Treiber, A., et al.Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptorBr. J. Clin. Pharmacol.54(5)561-562(2002)
T38158	StA-IFN-1	Others	Others
	StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective f...
T84958	19-alkyne Cholesterol 19-ethynyl Cholesterol	Others	Others
	19-Alkyne Cholesterol, an alkyne-derivatized form of cholesterol, is utilized to trace its localization and distribution within subcellular compartments of NIH3T3 cells and to explore cholesterol's involvement in hedgehog (Hh) signal transduction within Shh-LIGHT2 cells through click chemistry alongside diverse reporter azides.
T77926	PROTAC KRAS G12C degrader-1	PROTACs	PROTAC
	PROTACKRAS G12C degrader-1是基于Cereblon的KRASG12C PROTAC降解剂，能诱导CRBN/KRASG12C二聚化，并在报告细胞中降解GFP-KRASG12C。
T85163	27-alkyne Cholesterol Click Tag™ 27-alkyne Cholesterol	Others	Others
	27-Alkyne Cholesterol, an alkyne derivative of cholesterol, facilitates the investigation of cholesterol metabolism and localization through click chemistry with reporter azides in both fixed and living cells. It serves as a substrate for enzymes across diverse species such as bacteria, yeast, rat, and human.
T27125	DBPR-110 MB110,MB 110,MB-110	Others	Others
	DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ± 0.9 pM and >12,800,000, respectively. DBPR-110 reduced HCV2a replicon activity with
T36365	KAPA (hydrochloride) KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid	Others	Others
	Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized for many assay reporter applications. KAPA is a key intermediate in the biotin biosynthetic pathway.[1]
T71925	Isonanangenine B	Others	Others
	Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.
T85249	7-keto-25-hydroxy Cholesterol	Others	Others
	7-Keto-25-hydroxy Cholesterol, an oxysterol and proposed metabolite of 7-keto cholesterol and 7-dehydro cholesterol, binds to and activates Smoothened (Smo) at the conserved extracellular cysteine-rich domain (CRD) in a reporter assay. Additionally, it enhances the number of EGF high affinity binding sites in normal rat kidney (NRK) cells.
T84950	Palmitoyl Alkyne-Coenzyme A Click Tag™ Palmitoyl Alkyne-Coenzyme A	Others	Others
	Palmitoyl alkyne-coenzyme A (palmitoyl alkyne-CoA), a thioester formed from ω-alkynylated palmitic acid and CoA, serves as a chemical reporter for the labeling of palmitoylated proteins through click chemistry. This process utilizes probes such as biotin-azide or 3-azido-7-hydroxycoumarin for both in vitro and in vivo studies.
T83878	Z-CITCO	Others	Others
	Z-CITCO是构成型雄甾烷受体（CAR；在报告基因测定中，对人类受体的EC50 = 3.9 µM）的激动剂，同时也是CAR激动剂CITCO的顺式异构体。
T38159	STING Agonist 12b	Others	Others
	STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
T69408	GW590735 sodium	Others	Others
	GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.
T37466	CAY10766	Others	Others
	CAY10766 is an antiviral compound.1It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50= 0.24 μM). CAY10766 (1 μM) reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells. It also exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus.
T62726	Phenylpyropene C	Others	Others
	Phenylpyropene C (S14-95) 是一种 JAK/STAT 通路抑制剂，对 IFN-γ 介导的报告基因表达表现出抑制作用 (IC50:5.4~10.8 μM)。Phenylpyropene C 也是一种酰基辅酶 A 的抑制剂 (IC50: 16.0 μM)。
T37414	CAY10771	Others	Others
	CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM. 1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Ch...
T38223	N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide	Others	Others
	N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxisome proliferator-activated receptor α (PPARα) in a luciferase reporter assay and, in rats, it decreases food intake. It does not inhibit fatty acid amide hydrolase (FAAH).
T84541	Vinclozolin M2 M2	Others	Others
	Vinclozolin M2, an active metabolite of vinclozolin, is generated through successive esterase activity and decarboxylation in C. elegans, as well as decarboxylation in human liver microsomes. It functions as an antagonist to the mineralocorticoid (IC50= 1,400 nM) and androgen receptors (IC50= 0.17 nM), demonstrated in reporter assays with MCF-7 cells. This compound is exclusively sold for research and analytical purposes, tailored for controlled laboratory use, and is not available in bulk sizes...

化合物

Cat.No: T23383

Synonym: SR 11237

Target: Others, RAR/RXR

Cat.No: T22101

Target: S1P Receptor

Cat.No: T22818

Synonym: GR agonist 23a,GSK 9027,GSK-9027

Target: Glucocorticoid Receptor

4-Azido-L-phenylalanine hydrochloride

Cat.No: T14038L

Synonym: p-Azido-L-phenylalanine hydrochloride,p-Azidophenylalanine hydrochloride

Target: Others

Cat.No: T4043

Synonym: ETC159,ETC-1922159,ETC 159

Target: Wnt/beta-catenin, Porcupine

Cat.No: T15677

Target: Wnt/beta-catenin

Cat.No: T5636

Synonym: Adavivint (SM04690)

Target: Wnt/beta-catenin

CBL0137 hydrochloride

Cat.No: T4361

Synonym: CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride

Target: Others, NF-κB, p53

Cat.No: T4339

Target: DNA-PK, Others

Cat.No: T19850

Synonym: 索玛鲁肽,司美格鲁肽,索马鲁肽

Target: Glucagon Receptor

ML241 hydrochloride

Cat.No: T4684

Target: p97

BAR 501 impurity

Cat.No: T8752

Target: GPCR19

Cat.No: T77725

Synonym: IAG933

Target: YAP

IL-4-inhibitor-1

Cat.No: T36527

Target: IL Receptor

Cat.No: T37587

Target: ROR

Cat.No: T4687

Synonym: CBFβ-Runx1 inhibitor II,Ro 5-3335

Target: DNA/RNA Synthesis

Cat.No: T36587

Synonym: 8-Aminopyrene-1,3,6-trisulfonic acid trisodium

Target: Others

Cat.No: T13067

Target: ROR

2'-Deoxy-2'-fluorocytidine

Cat.No: T38238

Target: Nucleoside Antimetabolite/Analog, Influenza Virus

Cat.No: T23970

Synonym: DDD-00015314,DDD 00015314

Target: Others

VT-102 free base

Cat.No: T71424

Target: Others

VT101 free base

Cat.No: T68934

Target: Others

Atorvastatin ethyl ester

Cat.No: T10403

Target: Others

Atorvastatin methyl ester

Cat.No: T13562

Target: Others

ROX Reference Dye

Cat.No: TD0086

2-Ethynyl Adenosine

Cat.No: T29347

Synonym: 2-Ethynyl-Ade,2 Ethynyl Adenosine,2-Ethynyl-Adenosine

Target: Others

Cyanine 3 Tyramide

Cat.No: T39181

Synonym: Cyanine 3 Tyramide,Tyramide-Cy3

Silvestrol aglycone

Cat.No: T12916

Target: Others

ARS-1323-alkyne

Cat.No: T10374

Target: Ras

Cat.No: T37833

Target: Others

Enhanced Green Fluorescent Protein (EGFP) (200-208)

Cat.No: T40400

Cyanine 5 Tyramide

Cat.No: T38902

Synonym: Tyramide-Cy5

Desmethyl Bosentan

Cat.No: T37351

Target: Others

Cat.No: T38158

Target: Others

19-alkyne Cholesterol

Cat.No: T84958

Synonym: 19-ethynyl Cholesterol

Target: Others

PROTAC KRAS G12C degrader-1

Cat.No: T77926

Target: PROTACs

27-alkyne Cholesterol

Cat.No: T85163

Synonym: Click Tag™ 27-alkyne Cholesterol

Target: Others

Cat.No: T27125

Synonym: MB110,MB 110,MB-110

Target: Others

KAPA (hydrochloride)

Cat.No: T36365

Synonym: KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid

Target: Others

Isonanangenine B

Cat.No: T71925

Target: Others

7-keto-25-hydroxy Cholesterol

Cat.No: T85249

Target: Others

Palmitoyl Alkyne-Coenzyme A

Cat.No: T84950

Synonym: Click Tag™ Palmitoyl Alkyne-Coenzyme A

Target: Others

Cat.No: T83878

Target: Others

STING Agonist 12b

Cat.No: T38159

Target: Others

GW590735 sodium

Cat.No: T69408

Target: Others

Cat.No: T37466

Target: Others

Phenylpyropene C

Cat.No: T62726

Target: Others

Cat.No: T37414

Target: Others

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide

Cat.No: T38223

Target: Others

Cat.No: T84541

Synonym: M2

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T24729	Roseoflavin	Antibacterial	Microbiology/Virology
	Roseoflavin 是天然色素，起初分离自Streptomyces davawensis。Roseoflavin 是核黄素和黄素单核苷酸的抗代谢类似物，显示出抗菌活性。
T21205	Ponasterone A 坡那甾酮A,AI3-44686	Others	Others
	Ponasterone A 是一种蜕皮激素，能够高度亲和蜕皮激素受体。它能够使报告基因能够快速打开和关闭，是细胞和转基因动物中基因表达的有效调节剂。
TN7236	Cephalandole B	IL Receptor	Immunology/Inflammation
	cephalandole B 是一种从青黛中分离出两种吲哚生物碱，能明显地抑制了IL-17A 基因的表达，以剂量依赖的方式抑制了Jukat 细胞的IL-17A 荧光素酶报告。
T6808	Coelenterazine Oplophorus luciferin,Coelenteramine,腔肠素	Others	Others
	Coelenterazine (Coelenteramine) 是一种 apoaequorin 和 Renilla 荧光素酶的发光酶底物。它是超氧阴离子敏感化学发光探针，可用于检测过氧亚硝酸盐的化学发光。其中 Renilla 荧光素酶和底物 coelenterazine 被用作生物发光共振能量转移中检测蛋白质-蛋白质相互作用的生物发光供体。
TN4383	Kazinol U	IL Receptor; IκB/IKK; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.
TN3539	Broussonin A	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c
T36749	Herboxidiene	Others	Others
	Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo...

天然产物

Cat.No: T24729

Target: Antibacterial

Cat.No: T21205

Synonym: 坡那甾酮A,AI3-44686

Target: Others

Cat.No: TN7236

Target: IL Receptor

Cat.No: T6808

Synonym: Oplophorus luciferin,Coelenteramine,腔肠素

Target: Others

Cat.No: TN4383

Target: IL Receptor, IκB/IKK, NOS, NF-κB

Cat.No: TN3539

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

Cat.No: T36749

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01304	ER beta Protein, Human, Recombinant (E. coli, His) ESR2,Nuclear receptor subfamily 3 group A member 2,Estrogen ...	Human	E. coli
	Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight...
TMPH-01305	ER beta Protein, Human, Recombinant (His) Nuclear receptor subfamily 3 group A member 2,Estrogen recep...	Human	P. pastoris (Yeast)
	Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 61.1 kDa and the accessio...
TMPY-00499	TMP21 Protein, Human, Recombinant (mFc) Tmp-21-I,p23,S31III125,TMP21,P24(DELTA),transmembrane emp24-...	Human	HEK293 Cells
	TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long region from Thr(91) to Glu(110) within the extracellular region of TMED10 was found to be crucial for TMED10 interaction with both ALK5 and TbetaRII. Synthetic peptides corresponding to this region inhibit both TGF-beta-induced Smad2 phosphorylation and Smad-dependent transcriptio...
TMPY-00140	ABP1/AOC1 Protein, Human, Recombinant (His) amine oxidase, copper containing 1,DAO,ABP1,ABP,KAO,DAO1	Human	HEK293 Cells
	Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under co...
TMPJ-00886	ATF1 Protein, Human, Recombinant (His) Cyclic AMP-dependent transcription factor ATF-1,Activating t...	Human	E. coli
	Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the ...
TMPY-01383	PRMT6 Protein, Human, Recombinant (His & Flag) protein arginine methyltransferase 6,HRMT1L6	Human	HEK293 Cells
	Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H...
TMPY-01860	Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His) SEDC,collagen, type II, alpha 1,COL11A3,AOM,STL1,collagen, t...	Human	HEK293 Cells
	COL2A1 is the alpha-1 chain of type II collagen which is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of th...

重组蛋白

ER beta Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01304

Species: Human

Expression System: E. coli

ER beta Protein, Human, Recombinant (His)

Cat.No: TMPH-01305

Species: Human

Expression System: P. pastoris (Yeast)

TMP21 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00499

Species: Human

Expression System: HEK293 Cells

ABP1/AOC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00140

Species: Human

Expression System: HEK293 Cells

ATF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00886

Species: Human

Expression System: E. coli

PRMT6 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPY-01383

Species: Human

Expression System: HEK293 Cells

Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His)

Cat.No: TMPY-01860

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71306	Gemfibrozil-d6
	Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l...
T71293	Nifuroxazide-d4
	Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells, which have constitutive S...
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A12) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter* assay). ...

同位素标记化合物

Cat.No: T71306

Nifuroxazide-d4

Cat.No: T71293

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

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