108
21
4
10
25
7
Cat. No. | Product Name | ||
---|---|---|---|
L3980 | DNA损伤/修复库Plus | 667 compounds | |
667 种 DNA 损伤/修复靶向、结构新颖的化合物; | |||
L9200 | 药物功能重定位化合物库 | 4630 compounds | |
4630 种全球上市药物和临床药物的独特集合,可用于高通量筛选和高内涵筛选,是老药新用、新的药物靶点筛选和细胞诱导的有效工具。 | |||
L8110 | 细胞重编程化合物库 | 1813 compounds | |
1813 种重编程信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选 | |||
L3900 | DNA 损伤和修复分子库 | 910 compounds | |
910 个与 DNA 损伤和修复紧密相关的化合物集合,是高通量筛选,高内涵筛选的良好载体; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27088 |
CRS-3123
REP-3123,REP 3123,CRS 3123 |
Others | Others |
CRS-3123, a methionyl-tRNA synthetase inhibitor, is used potentially for the treatment of enteric infections. | |||
T30311 |
Bederocin
REP 8839,REP-8839,REP8839 |
Antibacterial | Microbiology/Virology |
Bederocin (REP8839) 是一种新型的甲硫酰基tRNA 合成酶(METS)抑制剂,对临床分离的金黄色葡萄球菌、化脓性链球菌和其他临床重要的革兰氏阳性细菌具有有效的抗菌活性。 | |||
T6562 |
Latrepirdine dihydrochloride
Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin |
Beta Amyloid; 5-HT Receptor; Adrenergic Receptor; GluR; Autophagy; Histamine Receptor | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) 是一种具有口服活性和神经活性的多种药物靶点的拮抗剂,可刺激淀粉样前体蛋白分解代谢和 β-淀粉样蛋白分泌。 | |||
T1088 |
Repaglinide
AG-EE 388 ZW,AG-EE 623ZW,瑞格列奈 |
Potassium Channel; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Repaglinide (AG-EE 623ZW) 是一种能够用于2 型糖尿病的胰岛素促分泌剂。 | |||
T61622 |
PREP inhibitor-1
|
Others | Others |
PREP inhibitor-1 是一种 prolyl oligopeptidase (PREP) 抑制剂,可用于研究阿尔茨海默症。 | |||
TP1627L |
Prepro VIP (111-122), human acetate
Prepro VIP (111-122), human acetate(123025-94-5 free base) |
Others | Others |
Prepro VIP (111-122), human acetate(123025-94-5 free base) 是一种前血管活性肠多肽 (VIP) 衍生肽,对应于残基 111-122。 | |||
T12705 |
Reparixin L-lysine salt
REPERTAXIN L-赖氨酸盐,Repertaxin L-lysine salt |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Reparixin L-lysine salt (Repertaxin L-lysine salt) 是趋化因子受体1/2 活化的变构抑制剂。 | |||
T2211 |
Dihydrostreptomycin sulfate
Dihydrostreptomycin sesquisulfate,双氢链霉索 |
Antibacterial; Antibiotic | Microbiology/Virology |
Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) 是一种氨基糖苷类抗生素,可研究牛、猪和羊的细菌性疾病。 | |||
T9417L |
gamma-preprotachykinin amide (72-92) acetate
gamma-preprotachykinin amide (72-92) acetate (114882-65-4 Free base) |
Others | Others |
gamma-preprotachykinin amide (72-92) acetate 是一种 21 个氨基酸的肽,属于速激肽 (TK) 家族,在其 C 末端序列中包括神经激肽 A (NKA)。它对中枢 NK-2 受体的亲和力高于 NKA;它对 NK-1 受体的亲和力较低,但是,它有效地刺激唾液分泌,这是由 NK-1 受体激活介导的。 | |||
T5150 |
Treprostinil
LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Treprostinil (Orenitram) 是有效的 DP1、IP 和 EP2 激动剂,EC50分别为0.6、1.9 和 6.2 nM。 | |||
T12427 |
Brepocitinib P-Tosylate
PF-06700841 P-Tosylate |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) 是一种有效的 JAK1和TYK2双重抑制剂,IC50值分别为 17 和 23 nM。它还抑制JAK2和JAK3,IC50值分别为 77 和 6.49 μM。 | |||
TP1050L |
Murepavadin acetate(944252-63-5 free base)
|
Antibacterial; Antibiotic | Microbiology/Virology |
Murepavadin acetate(944252-63-5 free base) 是一种有效且特异性的抗生素,用于治疗由铜绿假单胞菌引起的细菌感染。 Murepavadin acetate 靶向脂多糖转运蛋白 D。 | |||
T5171 |
Treprostinil Sodium
曲前列尼尔钠,UT-15 |
VEGFR; c-RET; Prostaglandin Receptor | Angiogenesis; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
Treprostinil Sodium (UT-15) 是有效的 DP1、IP 和 EP2 激动剂,EC50分别为0.6、1.9 和 6.2 nM。 | |||
TQ0010 |
Brepocitinib
PF-06700841 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Brepocitinib (PF-06700841) 是JAK1和TYK2双重抑制剂,IC50分别为 17 nM 和 23 nM。它抑制JAK2和JAK3的效果较弱,IC50分别为 77 nM 和 6.49 μM 。 | |||
T4071 |
Repotrectinib
TPX-0005,TPX 0005,TPX0005 |
Trk receptor; ROS; Src; ALK; ROS Kinase | Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
Repotrectinib (TPX-0005) 是ROS1(IC50=0.07 nM) 和TRK(对 TRKA/B/C 的IC50=0.83/0.05/0.1 nM) 抑制剂,能够抑制 WTALK(IC50=1.01 nM)。它具有抗癌作用。 | |||
T40042 |
Evifacotrep
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Evfacotrep 是一种有效的短期瞬态受体电位通道5 拮抗剂。Evfacotrep 可用于神经系统疾病的研究。 | |||
T19764 |
Trepibutone
AA-149,Colibil, Supacal,AA149,AA 149,曲匹布通 |
Others | Others |
Trepibutone 是一种酸性药物,具有不依赖于 pH 值的释放能力。 | |||
T1790 |
Fosaprepitant dimeglumine
福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂,可用于预防化疗引起的恶心呕吐。 | |||
T16732 |
Reproxalap
NS-2,ADX-102 |
Others | Others |
Reproxalap (NS-2) 是一种活性醛类隔离剂,可用于干眼症的研究。它能够与醛 (包括丙二醛和 4-羟基壬醛) 共价结合。 | |||
T63349 |
Treprostinil diethanolamine
UT-15C |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂,对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调,进而维持血管系统内的稳态,并造成人肺动脉的血管扩张。 | |||
T16014 |
Mavatrep
JNJ-39439335 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Mavatrep (JNJ-39439335) 是一种特异性的 TRPV1 拮抗剂,Ki 为 6.5 nM,可用于炎症性疼痛的研究。 | |||
T61934 |
Repinotan
BAY x 3702 free base |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Repinotan (BAY x 3702 free base) 是一种可透过血脑屏障(BBB)且具有口服活性和选择的 5-HT1A 受体激动剂,具有神经保护活性,可拮抗吗啡诱导的麻醉大鼠通气抑制,可用于研究急性缺血性中风和创伤性脑损伤。 | |||
T4163 |
Reparixin
DF 1681Y,Repertaxin,瑞帕利辛 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Reparixin (Repertaxin) 是两种 CXCL8 受体 CXCR1/2 的强效抑制剂,它对 CXCR2 介导的细胞迁移具有微弱的抑制作用 ,IC50为 100 nM。它强烈阻断 CXCR1 介导的趋化性,IC50为 1 nM。 | |||
T6337 |
RepSox
ALK5 Inhibitor II,SJN 2511,E-616452 |
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
RepSox (ALK5 Inhibitor II) 是一种 TGFβR-1/ALK5 的抑制剂,可以抑制 ATP 与 ALK5 结合 以及 ALK5 自磷酸化 (IC50=23/4 nM),具有选择性。RepSox 可以诱导 MEFs 细胞的脂肪生成。 | |||
T1743 |
Aprepitant
MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant` |
HIV Protease; Antibacterial; Antibiotic; Neurokinin receptor | GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Aprepitant (Aprepitant`) 是选择性和高亲和力的神经激肽1受体拮抗剂,Kd 值为86 pM。 | |||
T28518 |
Repinotan HCl
X-3702,X 3702,Bayx3702,X3702,Bay-x-3702,Bay x 3702 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Repinotan HCl (Bay-x-3702) 是一种可透过血脑屏障且具有口服活性、选择性和高效性的 5-HT1A 受体激动剂,是一种氨甲基苯并联苯胺衍生物。RRepinotan HCl 具有强效的神经保护作用,可用于研究缺血性卒中和创伤性脑损伤。 | |||
T16426 |
Asivatrep
PAC-14028 |
Others | Others |
Asivatrep is an effective and selective transient receptor potential vanilloid type I antagonist. | |||
TP2469 |
Preprosomatostatin (25-34)
|
||
Preprosomatostatin (25-34) is a peptide. | |||
T76389 |
Prepro-ANF (56-92), human
|
||
Prepro-ANF (56-92), human,是一种人类心房利钠因子的前体,同时也作为鸟苷酸环化酶的激活剂,有助于提升肾膜和肾单位微粒鸟苷酸环化酶的活性。 | |||
T81406 |
Preptin (rat)
|
||
Preptin 在剂量依赖的方式下刺激胎鼠原代成骨细胞和成骨样细胞系的增殖,影响表现在细胞数量和DNA合成上。 | |||
TP2292 |
survivin (baculoviral IAP repeat-containing protein 5) (21-28)
|
Others | Others |
Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibitions of apoptosis and mitosis regulation1. Survivin is one of the most uniformly up-regulated genes | |||
T34806 |
Terephthalamic acid, N-(5-(p-aminophenoxy)pentyl)-, methyl ester
|
Others | Others |
Terephthalamic acid, N-(5-(p-aminophenoxy)pentyl)-, methyl ester is a bioactive chemical. | |||
T25512 |
Hydroxystreptomycin
Streptomycin C |
Others | Others |
Hydroxystreptomycin is a new antibiotic isolated from Streptomyces Griseocarneus. | |||
T25461 |
Grepafloxacin, (S)-
L-Grepafloxacin |
Others | Others |
Grepafloxacin, (S)- is an oral broad-spectrum fluoroquinolone antibacterial used for the treatment of bacterial infections. | |||
T38801 |
Fobrepodacin
SPR720,pVXc-486 |
Others | Others |
Fobrepodacin (SPR720) is an orally active and potent phosphate prodrug of SPR719 (VXc-486). Fobrepodacin has potent bactericidal activities in vivo. | |||
T32520 |
Lac repressor fragment 33-38
|
Others | Others |
Lac repressor fragment 33-38 Lys-Arg-Glu-Lys-Val fragment from lac repressor. | |||
T124704 |
Ochrephilone
|
Others | Others |
Ochrephilone 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124704,CAS号为 53014-38-3。 | |||
T31491 |
Dimethyl terephthalate
|
Others | Others |
Dimethyl terephthalate is a diester obtained from terephthalic acid and methanol. It is a white solid that melts to give a distillable colorless liquid. | |||
T33705 |
N-Methylstreptothricin F
A37812,A 37812,A-37812 |
Others | Others |
N-Methylstreptothricin F is a streptothrycin isolated from actinomycete. | |||
T26063 |
Repromicin
De-epoxy rosamicin,Repromicinum |
Others | Others |
Repromicin is a chemical compound whose derivatives have strong antibacterial characteristics. | |||
T39165 |
Treprostinil palmitil
Treprostinil palmitil,INS-1009 |
Others | Others |
Treprostinil Palmitil (TP), a prodrug of the DP1 and EP2 agonist Treprostinil (UT-15), exhibits EC50 values of 0.6 and 6.2 nM, respectively. It is a pure prodrug without any inherent binding affinity for G-protein coupled receptors, including prostanoid receptors. | |||
T19806 |
Dihydrostreptomycin
Vibriomycin,Abiocine |
Others | Others |
Dihydrostreptomycin is an antibiotic. | |||
T64422 |
Murepavadin
|
||
Murepavadin is a highly potent, specific, macrocycle Pseudomonas antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa.. | |||
T76256 |
Erepdekinra
|
||
Erepdekinra 是一种白细胞介素-17A (IL-17A) 受体拮抗剂。 | |||
T13497 |
3'-Hydroxy Repaglinide
|
Others | Others |
3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid derivative and used as the treatment of type II diabetes. | |||
T16945 |
Streptolydigin
Portamycin |
Antibacterial | Microbiology/Virology |
Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki: 18 μM and a Kd: 15 μM). | |||
T40409 |
Tau Peptide (275-305) (Repeat 2 domain)
|
||
Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining the biochemical characteristics of the complete tau protein. | |||
T31996 |
Grepafloxacin Hydrochloride
DSSTox_CID_26692,OPC-17116,DSSTox_RID_81826,DSSTox_GSID_46692 |
Others | Others |
Grepafloxacin Hydrochloride is an antimicrobial agent, oral broad-spectrum fluoroquinolone. It is used to treat bacterial infections. | |||
T34721 |
Streptobiosamine
|
Others | Others |
Streptobiosamine is a disaccharide component of streptomycin. | |||
T19635 |
Repirinast
MY-5116,MY 5116,MY5116 |
Others | Others |
Repirinast is a mediator release inhibitor. It is used to treat asthma. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21066 |
Norepinephrine bitartrate salt
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Norepinephrine bitartrate salt 是一种肾上腺素能神经递质。 | |||
T1064 |
Norepinephrine bitartrate monohydrate
酒石酸去甲肾上腺素,Levophed,Noradrenaline bitartrate monohydrate,降肾上腺素 |
Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience |
Norepinephrine bitartrate monohydrate (Levophed) 是一种β1-选择性的肾上腺素能受体激动剂,EC50为 5.37 μM。 | |||
T8031 |
Terephthalic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Terephthalic acid 是一种三种酞酸盐的异构体,是聚酯 PET 的前体,能够用于制作服装和塑料。 | |||
TN6900 |
Reptoside
|
Others | Others |
Reptoside 可从杜仲和 Ajuga chamaepitys (L.) Schreb 根部和地上部分中提取,是杜仲治疗骨质疏松症的活性环烯醚萜苷之一。 | |||
T1679 |
Thiostrepton
Thiactin,Bryamycin,Alaninamide,硫链丝菌素 |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Thiostrepton (Alaninamide) 是一种选择性抑制FOXM1的抗生素。FOXM1会与 YAP/TEAD 复合物结合,形成YAP/TEAD/FOXM1 复合物。 | |||
T1507 |
Streptozocin
STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889 |
DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Streptozocin (NSC-85998) 是一种抗生素,可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性,常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定,建议现配现用。 | |||
T0060 |
Streptomycin sulfate
Plantomycin,Estreptomicina,Phytomycin,硫酸链霉素 |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Streptomycin sulfate (Phytomycin) 是一种能抑制蛋白质合成的氨基糖苷类抗生素。 | |||
T13655 |
DL-Norepinephrine hydrochloride
去甲肾上腺素盐酸盐,Lys,DL-lysine |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
DL-Norepinephrine hydrochloride (DL-lysine) 是一种靶向α1 adrenoceptor 和β1 adrenoceptor 的神经递质,可降低心内膜下氧分压。它是一种模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。 | |||
T7044 |
Norepinephrine
去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol |
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome |
Norepinephrine (Levophed) 属于生物碱类天然产物,是一种神经递质,一种肾上腺素能受体 (AR) 的激动剂,对 α1、α2 和 β1 AR 具有激活活性。Norepinephrine 被用作抗休克的血管活性剂。 | |||
T34495 |
Salireposide
|
||
Salireposide is a salicinoid phenolic glycoside that is isolated from Symplocos racemosa. | |||
T39445 |
Korepimedoside C
Epimedin I,朝藿苷丙 |
Others | Others |
Korepimedoside C, also known as Epimedin I, is a flavonol glycoside derived from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a renowned Chinese herbal medicine that has been extensively studied for its potential in addressing impotence, osteoporosis, immune suppression, and cardiovascular diseases. | |||
TN7532 |
Streptimidone
NSC 66645,Ao58A |
Others | Others |
Streptimidone, a metabolite produced by Streptomyces, exhibits various biological activities, including inhibiting protein synthesis at 50 µg/ml in cell-free assays and reducing tumor growth in rat xenograft models of H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma at daily doses of 12.5 and 25 mg/kg. | |||
TN3275 |
8-Epicrepiside E
|
Others | Others |
8-Epicrepiside E是一种天然产物,属于菊科风毛菊属,其产品编号为 TN3275,CAS号为 93395-30-3。8-Epicrepiside E可用作对照参考。 | |||
T16946 |
Streptonigrin
Bruneomycin |
Others | Others |
Streptonigrin is a natural product produced by Streptomyces flocculus, has both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor (IC50s: 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD | |||
T60245 |
Norepinephrine hydrochloride
|
Others | Others |
Norepinephrine hydrochloride (Levarterenol hydrochloride) 是一种β1选择性的肾上腺素受体激动剂,EC50值为 5.37 μM。 | |||
T37751 |
Streptazolin
|
Others | Others |
Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells. | |||
T31429 |
Dibutyl terephthalate
|
||
Dibutyl terephthalate is a biochemical. | |||
T20473 |
Bis(2-ethylhexyl) terephthalate
|
||
Bis(2-ethylhexyl) terephthalate is an agent of biochemical. | |||
T13880 |
Salirepin
|
Others | Others |
Salirepin is a phenolic glycoside isolated from fruits of Idesia polycarpa, Salirepin inhibits LPS-induced nitric oxide production. | |||
T19565 |
Streptolysin O
|
Others | Others |
Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state . | |||
TN4488 |
Mallorepine
|
Others | Others |
Mallorepine may propably be an intermediate on the biosynthetic pathway from nicotinamide (II) to ricinine (III). |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00583 |
Rep Protein, E. coli, Recombinant (GST)
ATP-dependent DNA helicase Rep,rep,DNA 3'-... |
E. coli | E. coli |
Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. | |||
TMPH-00147 |
IBV (strain KB8523) Replicase polyprotein 1ab (His)
ORF1ab polyprotein,Replicase polyprotein 1ab,re... |
IBV | Baculovirus Insect Cells |
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.; NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. IBV (strain KB8523) Replicase polyprotein 1ab (His) is expressed in Baculo... | |||
TMPH-00028 |
Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)
Protein Rep78 |
AAV-2 | E. coli |
Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factors in site-specific integration of the viral genome. Regulates host PKA activity by interacting with host PRKX as a mechanism of i... | |||
TMPY-05346 |
CRISPR-Cas9 Protein, Streptococcus pyogenes, Recombinant (His)
SpyCas9 |
Streptococcus pyogenes | Baculovirus Insect Cells |
CRISPR-Cas9 Protein, Streptococcus pyogenes, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 163 kDa and the accession number is Q99ZW2. | |||
TMPH-03641 |
TroA Protein, Treponema pallidum, Recombinant (His & Myc)
Zinc-binding protein TroA,troA,Tromp-1 |
Treponema pallidum | E. coli |
Part of an ATP-driven transport system TroABCD for zinc. Substrate-binding protein involved in the transport of zinc across the cytoplasmic membrane. TroA Protein, Treponema pallidum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.2 kDa and the accession number is P96116. | |||
TMPH-03604 |
Phosphinothricin N-acetyltransferase Protein, Streptomyces hygroscopicus, Recombinant (His)
Phosphinothricin-resistance protein,Phosphinothricin N-acety... |
Streptomyces hygroscopicus | E. coli |
Inactivates phosphinothricin (PPT) by transfer of an acetyl group from acetyl CoA. Can also acetylate demethylphosphinothricin but not PTT or glutamate. This enzyme is an effector of phosphinothricin tripeptide (PTT or bialaphos) resistance. Phosphinothricin N-acetyltransferase Protein, Streptomyces hygroscopicus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.6 kDa and the accession number is P16426. | |||
TMPH-03642 |
TP_0608 Protein, Treponema pallidum, Recombinant (His & Myc)
Uncharacterized protein TP_0608 |
Treponema pallidum | E. coli |
N/A. TP_0608 Protein, Treponema pallidum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.5 kDa and the accession number is O83617. | |||
TMPY-06023 |
IdeS Protein, Streptococcus pyogenes, Recombinant (His)
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Streptococcus pyogenes | E. coli |
IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. IdeS Protein, Streptococcus pyogenes, Recombinant (His) is expressed in E. coli expression system with His t... | |||
TMPK-00754 |
LY6G6D Protein, Human, Recombinant (His & Strep-II)
C6orf23,MEGT1,Protein Ly6-D,NG25,G6D,Ly6-D |
Human | HEK293 Cells |
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Human, Recombinant (His & Strep-II) is ex... | |||
TMPK-00696 |
PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)
MAPKAPK5,MK5,MAPKAP-K5,MK-5,MAPKAPK-5 |
Human | Baculovirus Insect Cells |
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-activated protein kinase activated protein kinase 5 [MAPKAPK5]) functions downstream of p38alpha and p38beta in mediating the signaling of the p38 pathway. | |||
TMPH-03605 |
CHOD Protein, Streptomyces sp., Recombinant (GST)
choA,Cholesterol isomerase,CHOD,Cholesterol oxidase |
Streptomyces | E. coli |
Bifunctional enzyme that catalyzes the oxidation of the 3-beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product. CHOD Protein, Streptomyces sp., Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 81.9 kDa and the accession number is P12676. | |||
TMPH-03598 |
Streptopain Protein, S. pyogenes serotype M28, Recombinant (His & SUMO)
SPE B,Streptococcus peptidase A,Streptopai... |
Streptococcus pyogenes | E. coli |
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Streptopain Protein, S. pyogenes serotype M28, Recombinant (His & SUMO) is expressed in E. coli expression system with... | |||
TMPH-03640 |
34 kDa membrane antigen Protein, Treponema pallidum, Recombinant (His & Myc)
34 kDa membrane antigen,Pathogen-specific membrane antigen |
Treponema pallidum | E. coli |
This antigen is a pathogen-specific membrane immunogen. 34 kDa membrane antigen Protein, Treponema pallidum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.1 kDa and the accession number is P19478. | |||
TMPH-00528 |
Recombination and repair protein Protein, Enterobacteria phage T4, Recombinant (His)
UVSX,Recombination and repair protein |
Enterobacteria phage T4 | E. coli |
Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins. | |||
TMPH-03601 |
Streptavidin Protein, S. avidinii, Recombinant (His)
Streptavidin |
Streptomyces avidinii | P. pastoris (Yeast) |
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). Streptavidin Protein, S. avidinii, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.5 kDa and the accession number is P22629. | |||
TMPH-03607 |
HOE-467A Protein, Streptomyces tendae, Recombinant (His & Myc & SUMO)
Tendamistat,Alpha-amylase inhibitor HOE-467A |
Streptomyces tendae | E. coli |
Inhibits mammalian alpha-amylases specifically but has no action on plant and microbial alpha-amylases. Forms a tight stoichiometric 1:1 complex with alpha-amylase. HOE-467A Protein, Streptomyces tendae, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 28.0 kDa and the accession number is P01092. | |||
TMPH-00646 |
LexA repressor Protein, E. coli, Recombinant (His & SUMO)
lexA,LexA repressor |
E. coli | E. coli |
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment.The SOS response controls an ap... | |||
TMPY-06179 |
IdeS Protein, Streptococcus pyogenes, Recombinant (His & GST)
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Streptococcus pyogenes | E. coli |
IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. IdeS Protein, Streptococcus pyogenes, Recombinant (His & GST) is expressed in E. coli expression system with... | |||
TMPJ-01028 |
Claudin-18.2 Protein, Human, Recombinant (Twin strep & Flag)
Claudin 18.2,CLDN18,Claudin-18,CLDN18.2,Claudin-18.2 |
Human | HEK293 Cells |
Claudin-18 (CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. Human CLDN18.2 is highly expressed in a signifcant proportion of gastric and pancreat... | |||
TMPH-00514 |
Endo H Protein, Streptomyces plicatus, Recombinant (His)
Endoglycosidase H,Endo-beta-N-acetylglucosaminidase H,Endo H |
Streptomyces plicatus | P. pastoris (Yeast) |
Cleaves asparagine-linked oligomannose and hybrid, but not complex, oligosaccharides from glycoproteins. | |||
TMPH-03643 |
TmpB Protein, Treponema phagedenis, Recombinant (His & Myc)
Treponemal membrane protein B,tmpB,Antigen TmpB |
Treponema phagedenis | E. coli |
Tmp may serve as a porin or transport protein for large molecules. TmpB Protein, Treponema phagedenis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is P29720. | |||
TMPH-00644 |
Lactose operon repressor Protein, E. coli, Recombinant (His & SUMO)
Lactose operon repressor,lacI |
E. coli | E. coli |
Repressor of the lactose operon. Binds allolactose as an inducer. | |||
TMPH-03606 |
P3H 1 Protein, Streptomyces sp., Recombinant (His & Myc)
Proline 3-hydroxylase type I,L-proline cis-3-hydroxylase 1,P... |
Streptomyces | E. coli |
Dioxygenase that catalyzes the 2-oxoglutarate-dependent selective hydroxylation of free L-proline to cis-3-hydroxy-L-proline (cis-3-Hyp). D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, and 3,4-dehydro-DL-proline are not substrates. P3H 1 Protein, Streptomyces sp., Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.0 kDa and the accession number is P96010. | |||
TMPH-03599 |
Streptopain Protein, S. pyogenes, Recombinant (His & SUMO)
Group A streptococcal cysteine protease,SPE B,St |
Streptococcus pyogenes | E. coli |
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Streptopain Protein, S. pyogenes, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO... | |||
TMPY-06942 |
Claudin-18 Protein, Human, Recombinant (His & Strep)
SFTA5,claudin 18,SFTPJ |
Human | HEK293 Cells |
Claudin-18 Protein, Human, Recombinant (His & Strep) is expressed in HEK293 mammalian cells with His and Strep tag. The predicted molecular weight is 32.34 kDa and the accession number is P56856-2. |
Cat. No. | Product Name | Target | Signaling Pathways |
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T19548 |
Repaglinide D5
AG-EE 623ZW D5,瑞格列奈 D5 |
Others | Others |
Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus. | |||
TMIH-0045 |
3-Hydroxy Repaglinide-d5
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3-Hydroxy Repaglinide-d5 是 3-Hydroxy Repaglinide 的氘代化合物。 | |||
TMIJ-0155 |
rac-Aprepitant-d4 (enantiomer)
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rac-Aprepitant-d4 (enantiomer) 是 rac-Aprepitant 的氘代化合物。rac-Aprepitant 的 CAS 号为 170729-80-3。 | |||
TMIJ-0427 |
Terephthalic-d4 Acid
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Terephthalic-d4 Acid 是 Terephthalic Acid 的氘代化合物。Terephthalic Acid 的 CAS 号为 100-21-0。Terephthalic acid 是一种三种酞酸盐的异构体,是聚酯PET的前体,能够用于制作服装和塑料。 | |||
TMIJ-0055 |
DL-Norepinephrine-d6 HCl
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DL-Norepinephrine-d6 HCl 是 DL-NorepinephrineHCl 的氘代化合物。DL-NorepinephrineHCl 的 CAS 号为 55-27-6。DL-Norepinephrine hydrochloride 是一种靶向α1 adrenoceptor和β1 adrenoceptor的神经递质,可降低心内膜下氧分压。它是一种模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。 | |||
TMIJ-0519 |
Fosaprepitant-d4 Dimeglumine
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Fosaprepitant-d4 Dimeglumine 是 Fosaprepitant Dimeglumine 的氘代化合物。Fosaprepitant Dimeglumine 的 CAS 号为 265121-04-8。Fosaprepitant dimeglumine 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂,可用于预防化疗引起的恶心呕吐。 | |||
T35513 |
13C15-Nivalenol
13C15-Nivalenol |
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13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026... |