91
15
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35880 |
Renin Fluorogenic Substrate
|
Others | Others |
The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other. After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm. | |||
T38900 |
Renin FRET Substrate I
|
||
Renin FRET Substrate I is a specific compound that functions as a substrate for human renin. It is specifically designed to contain the exact cleavage site found in the N-terminal peptide of human angiotensinogen. | |||
TP2351 |
Renin inhibitory peptide
Pro-his-pro-phe-his-phe-phe-val-tyr-lys |
||
Renin inhibitory peptide is an analog of angiotensinogen. | |||
TP2351L |
Renin inhibitory peptide, statine
SCRIP,Iva-his-pro-phe-his-sta-leu-phe-NH2 |
||
Renin inhibitory peptide, statine is a effective, specific statine-containing renin inhibitor. | |||
T80244 |
Renin inhibitor peptide,rat
|
||
Renin inhibitorpeptide,rat 是一种特定的大鼠肾素抑制剂,具有生物活性的肽。 | |||
T76443 |
Renin substrate 1
|
||
Reninsubstrate 1 是一种对酶具有高亲和力的肾素 (renin) 底物。 | |||
T62138 |
Renin inhibitor-1
|
Others | Others |
Renin inhibitor-1 (compound 26) 是一种有效的、口服具有活力的肾素抑制剂,能够作用于 rh-renin (IC50: 0.9 nM) 和 hPRA (IC50: 1.8 nM)。Renin inhibitor-1 具有抗高血压作用,具有潜力进行高血压和心血管/肾脏疾病的研究。 | |||
T26127 |
R-PEP 27
Renin inhibitory peptide, R-pep-27,Pro-his-pro-phe-his-statine-ile-phe-NH2 |
Others | Others |
R-PEP 27 is an inhibitor of potent renin, decreased plasma angiotensin II, and blood pressure in normal volunteers. | |||
TP1929L1 |
Saralasin acetate(34273-10-4 free base)
|
RAAS | Endocrinology/Hormones |
Saralasin acetate(34273-10-4 free base) 是一种非选择性血管紧张素 II 拮抗剂。 | |||
T7714 |
Temocapil
|
Tyrosinase | Proteases/Proteasome |
Temocapil 是一种酪氨酸激酶抑制剂。 | |||
T1520 |
Aliskiren hemifumarate
阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B |
RAAS; Autophagy | Autophagy; Endocrinology/Hormones |
Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂,IC50为1.5 nM,具有抗高血压活性。 | |||
T3064 |
VTP-27999
VTP27999 |
RAAS | Endocrinology/Hormones |
VTP-27999是烷基胺肾素抑制剂,它已用于研究肾功能基础科学的试验。 | |||
T7668 |
VTP-27999 TFA
N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯 2,2,2-三氟乙酸盐 |
RAAS | Endocrinology/Hormones |
VTP-27999 TFA 是烷基胺肾素抑制剂(IC50:0.47 nM)。 | |||
T6666 |
Sevelamer Carbonate
|
Others | Others |
Sevelamer carbonate 是一种口服具有活力的非钙基磷酸盐结合剂,能有效降低体内血清磷水平,但对体内血清钙、氯水平影响极小,可用于研究慢性肾脏病的高磷血症。它被认为是七氟乙烯的一种改进的缓冲形式。 | |||
T6698 |
Temocapril hydrochloride
CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利 |
RAAS | Endocrinology/Hormones |
Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。 | |||
T37683 |
3-Hydroxykynurenine
3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine |
Others | Others |
3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) 是色氨酸的活性代谢物,可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。 | |||
T71760 |
4-Chlorokynurenine
|
Others | Others |
4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor. | |||
T124831 |
Scillarenin
|
Others | Others |
Scillarenin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124831,CAS号为 465-22-5。 | |||
T72430 |
L-Kynurenine sulfate
|
Others | Others |
L-Kynurenine sulfate 是一种芳香烃受体AHR 激动剂,可激活 AHR 导向的初始T 细胞极化至抗炎 Treg 表型。 | |||
T125390 |
Glisoprenin D
|
Others | Others |
Glisoprenin D 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125390,CAS号为 205594-89-4。 | |||
T70549 |
Kadsurenin L
|
Others | Others |
Kadsurenin L is a neolignan originally isolated from Piper kadsura. It has a role as a platelet-activating factor receptor antagonist and a plant metabolite. | |||
T3011L |
Kynurenine sulfate monohydrate
L-Kynurenine sulfate monohydrate |
Others | Others |
Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mamma | |||
T34194 |
Puntarenine
|
Others | Others |
Puntarenine is an alkaloid of the isohomoprotoberberine family that has shown marginal activity against the dermatophytic fungus Trichophyton mentagrophytes and the yeast Saccharomyces cerevisiae. | |||
T32361 |
Karenin
|
Others | Others |
Karenin is a bioactive chemical. | |||
T22233 |
Aliskiren
CGP60536B,CGP 60536,SPP 100 |
RAAS | Endocrinology/Hormones |
Aliskiren (CGP 60536) 是一种具有口服活性和高效性的肾素抑制剂(IC50:1.5 nM),具有抗高血压活性,可用于治疗多种心血管疾病。 | |||
T4313 |
Tinoridine hydrochloride
盐酸替诺立定,Nonflamin,Y-3642 hydrochloride |
COX; Glutathione Peroxidase | Immunology/Inflammation; Metabolism; Neuroscience |
Tinoridine hydrochloride (Y-3642 hydrochloride) 是非甾体抗炎药,具有显著的自由基清除和抗过氧化物特性。 | |||
T28950 |
Terlakiren
CP 80794,CP-80,794 |
RAAS | Endocrinology/Hormones |
Terlakiren (CP-80,794) 是一种具有口服活性和高效性的肾素 (Renin) 抑制剂,抑制人肾素的效能,可用于研究高血压类的神经系统疾病。 | |||
TP1842L |
Angiotensinogen (1-14), human acetate
|
Endogenous Metabolite | Metabolism |
Angiotensinogen (1-14), human acetate 是血管紧张素原的片段,它是肾素-血管紧张素系统的被动底物。 | |||
T3695 |
Pepstatin
抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C |
Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination |
Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂,可抑制 HIV 蛋白酶的活性。 | |||
T2639 |
LY2811376
|
Beta Amyloid; Beta-Secretase; BACE | Neuroscience |
LY2811376 是可口服的非肽段β-secretase (BACE1)抑制剂,IC50=239 nM-249 nM,能够降低 Aβ 蛋白的分泌,EC50=300 nM。 | |||
T37496L |
Alamandine TFA
|
RAAS | Endocrinology/Hormones |
Alamandine TFA 是肾素-血管紧张素系统 (RAS) 的成员,是一种血管活性肽,是 G 蛋白偶联受体 MrgD 的内源性配体。它通过抗高血压作用来保护肾脏和心脏。 | |||
TP1295 |
Angiotensin I (human, mouse, rat)
Angiotensin 1 Human,血管紧张素 1 (人) |
Others | Others |
Angiotensin I (human, mouse, rat) 是血管紧张素Ⅱ的前体物质,在血管紧张素转化酶 (ACE) 的参与下裂解成血管紧张素Ⅱ。 | |||
T22574L |
Angiotensin 1/2 (5-7) acetate
|
RAAS | Endocrinology/Hormones |
Angiotensin 1/2 (5-7) acetate 是一种具有 H2N-Ile-His-Pro-OH 序列的肽。血管紧张素是一种寡肽,是一种激素和一种强大的双肽原。它来源于前体分子血管紧张素原,一种在肝脏中产生的血清球蛋白。它在肾素-血管紧张素系统中起重要作用。 | |||
T14123 |
ACT 178882
|
RAAS | Endocrinology/Hormones |
ACT 178882 is a new Renin inhibitor (IC50: 1.4 nM). | |||
T26439 |
A 74273
A-74273,A74273 |
Others | Others |
A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition. | |||
T28328 |
PD 132002
PD-132002,PD132002 |
Others | Others |
PD 132002 is a renin inhibitor. | |||
T27306 |
Fasidotril
BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137 |
Others | Others |
Fasidotril is a NEP/ACE inhibitor. Fasidotril was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in patients with essential hypertension. | |||
T30829 |
Cgp 38560
Cgp38560,Cgp-38560 |
Others | Others |
CGP 38560 is a potent renin inhibitor. | |||
T26431 |
A 65317
A-65317,A65317 |
Others | Others |
A 65317 is a selective renin inhibitor that causes a blockade of the renin-angiotensin system. | |||
T25233 |
CH 66
CH66,Piv-his-pro-phe-leu(OH)leu-tyr-tyr-ser-NH2,CH-66 |
Others | Others |
CH 66 is an inhibitor of renin. | |||
T25369 |
Emd 52297
Emd-52297,Emd52297 |
Others | Others |
Emd 52297 is an inhibitor of renin. | |||
T71318 |
H 218-54
|
Others | Others |
H 218-54 is a renin inhibitor. | |||
T25370 |
Emd 55068
Emd-55068,Emd55068 |
Others | Others |
Emd 55068 is a synthetic antagonist of renin. | |||
T26170 |
S 863390
S863390,S-86,3390 S86,3390,S 86,3390,S-863390 |
Others | Others |
S 863390 is a renin inhibitor. | |||
T29204 |
Zankiren
A72517,A-72517,A 72617 |
Others | Others |
Zankiren is a renin inhibitor. Zankiren can reduce blood pressure, plasma renin activity, and angiotension II. | |||
T25368 |
Emd 51921
Emd51921,Emd-51921,Emd-51,921,Emd 51,921,Emd 51 921 |
Others | Others |
Emd 51921 is a linear peptide renin inhibitor. | |||
T25386 |
ES 6864
ES-6864,ES6864 |
Others | Others |
ES 6864 is an orally active inhibitor of renin. | |||
T31033 |
CP 81282
CP81282,CP-81,282,CP-81282 |
Others | Others |
CP 81282 inhibits human renin and endothiapepsin. | |||
T24284 |
L 363564
L-363,564,L-363564,L363,564,L363564,L 363,564 |
Others | Others |
L 363564 is a kidney renin inhibitor. | |||
T26220 |
SR 43845
SR43845,SR-43845 |
Others | Others |
SR 43845 is an inhibitor of renin. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S0290 |
Araloside A
Chikusetsusaponin IV,竹节参皂苷IV |
RAAS; Fas/FasL | Apoptosis; Endocrinology/Hormones |
Araloside A (Chikusetsusaponin IV) 是竹节参中的一种成分,对肾素renin 具有低抑制活性(IC50:77.4 μM)。 | |||
T10938 |
D-Kynurenine
D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103 |
GPR; AhR; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
TN6778 |
Umbelliprenin
伞形花醚,7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin |
IL Receptor | Immunology/Inflammation |
Umbelliprenin (7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin) 可减轻神经性疼痛,并降低血清 IL-6 水平和氧化应激。 | |||
TN4302 |
Isokadsurenin D
|
Others | Others |
Isokadsurenin D是一种天然产物,属于五味子科南五味子属,其产品编号为 TN4302,CAS号为 147976-35-0。Isokadsurenin D可用作对照参考。 | |||
T2S1727 |
Lycorenine
|
Antifection | Microbiology/Virology |
Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph | |||
T79948 |
Kadsurenin B
|
Others | Others |
Kadsurenin B为PAF(platelet-activating factor)拮抗剂,展现出神经保护作用。该化合物在药理学领域显示出广泛的研究潜力,包括抗菌、抗炎、神经保护、抗氧化、抗血小板聚集、细胞毒性和抗寄生虫等效能。 | |||
TN3054 |
4-O-Demethylisokadsurenin D
|
Others | Others |
4-O-Demethylisokadsurenin D 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3054,CAS号为 89104-59-6。 | |||
T3S0804 |
Worenine
甲基黄连碱,Worenin |
Others | Others |
Worenine (Worenin) 是一种从黄连中提取的物质。它在大鼠体内第一阶段代谢中显示出脱氢,氢化,羟基化和脱亚甲基反应。在大鼠体内 II 期代谢中显示为硫酸化和葡萄糖醛酸化反应。 | |||
TN4365 |
Kadsurenin D
|
Others | Others |
Kadsurenin D 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4365,CAS号为 140669-89-2。 | |||
TN3055 |
4-O-Demethylkadsurenin D
|
Others | Others |
4-O-Demethylkadsurenin D 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3055,CAS号为 127179-70-8。 | |||
T81994 |
Kadsurenin A
|
||
Kadsurenin A是一种生物活性木脂素,具有潜在的药用价值。 | |||
T0522 |
Diammonium Glycyrrhizinate
甘草酸二铵,Glycyrrhizin |
Dehydrogenase | Metabolism |
Diammonium Glycyrrhizinate (Glycyrrhizin) 是分离自甘草中的化合物,有抗炎作用。 | |||
T38649 |
Lyciumin A
|
Others | Others |
Lyciumin A, a cyclic octapeptide, possesses inhibitory properties against proteases, renin, and angiotensin-converting enzyme. It holds potential for hypertension research. | |||
T19186 |
Aldosterone
|
Others | Others |
Aldosterone is the primary mineralocorticoid. Aldosterone is synthesized and secreted in response to renin-angiotensin system activation or high dietary potassium by the zona glomerulosa of the adrenal cortex. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0518 |
L-Kynurenine-d4-1
|
||
L-Kynurenine-d4-1 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
TMID-0071 |
L-Kynurenine-d4
|
||
L-Kynurenine-d4 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
T19187 |
Aliskiren D6 hemifumarate
CGP 60536 D6 hemifumarate,SPP 100 D6 hemifumarate,CGP60536B D6 hemifumarate |
RAAS | Endocrinology/Hormones |
Aliskiren (CGP 60536) D6 hemifumarate is a deuterium-labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM). | |||
T10282 |
Aliskiren D6 Hydrochloride
SPP 100 D6 Hydrochloride,CGP60536B D6 Hydrochloride,CGP 60536 D6 Hydrochloride |
Others | Others |
Aliskiren (CGP 60536) D6 Hydrochloride is a deuterium-labeled Aliskiren. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM). | |||
TMIJ-0317 |
Nadolol-d9 (Mixture of Diastereomers)
|
||
Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 |